eF-site ID 1zzu-A PDB Code 1zzu Chain A click to enlarge Title Rat nNOS D597N/M336V double mutant with L-N(omega)-Nitroarginine-2,4-L-Diaminobutyric Amide Bound Classification OXIDOREDUCTASE Compound Nitric-oxide synthase, brain Source null (NOS1_RAT) Sequence A:  RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIVLP TKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIE STSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDA RDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGK HDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQG WKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHP KFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYM GTEIGVRNYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQA LVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCR GGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPD PWNTHVW Description Functional site 1) chain A residue 417 type sequence G description BINDING SITE FOR RESIDUE ACT A 860 source : AC1 2) chain A residue 587 type sequence W description BINDING SITE FOR RESIDUE ACT A 860 source : AC1 3) chain A residue 649 type sequence V description BINDING SITE FOR RESIDUE ACT A 860 source : AC1 4) chain A residue 657 type sequence S description BINDING SITE FOR RESIDUE ACT A 860 source : AC1 5) chain A residue 326 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC3 6) chain A residue 331 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC3 7) chain A residue 477 type sequence S description BINDING SITE FOR RESIDUE MTL A 870 source : AC4 8) chain A residue 481 type sequence R description BINDING SITE FOR RESIDUE MTL A 870 source : AC4 9) chain A residue 497 type sequence A description BINDING SITE FOR RESIDUE MTL A 870 source : AC4 10) chain A residue 498 type sequence N description BINDING SITE FOR RESIDUE MTL A 870 source : AC4 11) chain A residue 500 type sequence Q description BINDING SITE FOR RESIDUE MTL A 870 source : AC4 12) chain A residue 501 type sequence F description BINDING SITE FOR RESIDUE MTL A 870 source : AC4 13) chain A residue 569 type sequence N description BINDING SITE FOR RESIDUE MTL A 870 source : AC4 14) chain A residue 709 type sequence D description BINDING SITE FOR RESIDUE MTL A 870 source : AC4 15) chain A residue 711 type sequence W description BINDING SITE FOR RESIDUE MTL A 870 source : AC4 16) chain A residue 409 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 17) chain A residue 414 type sequence R description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 18) chain A residue 415 type sequence C description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 19) chain A residue 457 type sequence S description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 20) chain A residue 584 type sequence F description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 21) chain A residue 585 type sequence S description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 22) chain A residue 587 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 23) chain A residue 592 type sequence E description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 24) chain A residue 678 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 25) chain A residue 706 type sequence Y description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 26) chain A residue 334 type sequence S description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 27) chain A residue 336 type sequence V description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 28) chain A residue 596 type sequence R description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 29) chain A residue 677 type sequence V description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 30) chain A residue 678 type sequence W description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 31) chain A residue 477 type sequence S description BINDING SITE FOR RESIDUE DP1 A 790 source : AC8 32) chain A residue 478 type sequence Q description BINDING SITE FOR RESIDUE DP1 A 790 source : AC8 33) chain A residue 565 type sequence P description BINDING SITE FOR RESIDUE DP1 A 790 source : AC8 34) chain A residue 567 type sequence V description BINDING SITE FOR RESIDUE DP1 A 790 source : AC8 35) chain A residue 569 type sequence N description BINDING SITE FOR RESIDUE DP1 A 790 source : AC8 36) chain A residue 585 type sequence S description BINDING SITE FOR RESIDUE DP1 A 790 source : AC8 37) chain A residue 586 type sequence G description BINDING SITE FOR RESIDUE DP1 A 790 source : AC8 38) chain A residue 587 type sequence W description BINDING SITE FOR RESIDUE DP1 A 790 source : AC8 39) chain A residue 592 type sequence E description BINDING SITE FOR RESIDUE DP1 A 790 source : AC8 40) chain A residue 706 type sequence Y description BINDING SITE FOR RESIDUE DP1 A 790 source : AC8 41) chain A residue 676 type sequence W description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 42) chain A residue 691 type sequence F description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 43) chain A residue 692 type sequence H description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 44) chain A residue 336 type sequence V description BINDING SITE FOR RESIDUE GOL A 880 source : BC3 45) chain A residue 596 type sequence R description BINDING SITE FOR RESIDUE GOL A 880 source : BC3 46) chain A residue 678 type sequence W description BINDING SITE FOR RESIDUE GOL A 880 source : BC3 47) chain A residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 48) chain A residue 587 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 49) chain A residue 588 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 50) chain A residue 592 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 51) chain A residue 677 type BINDING sequence V description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 52) chain A residue 678 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 53) chain A residue 691 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 54) chain A residue 706 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 55) chain A residue 334 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 56) chain A residue 414-421 type prosite sequence RCVGRIQW description NOS Nitric oxide synthase (NOS) signature. RCVGRIqW source prosite : PS60001 57) chain A residue 415 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI2

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