eF-site ID 1zzq-AB PDB Code 1zzq Chain A, B click to enlarge Title Rat nNOS D597N mutant with L-N(omega)-Nitroarginine-(4R)-amino-L-proline amide bound Classification OXIDOREDUCTASE Compound Nitric-oxide synthase, brain Source Rattus norvegicus (Rat) (NOS1_RAT) Sequence A:  RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLP TKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIE STSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDA RDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGK HDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQG WKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHP KFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYM GTEIGVRNYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQA LVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCR GGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPD PWNTHVW B:  RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLP VRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKE IESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVF DARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTD GKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQ QGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIR HPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGW YMGTEIGVRNYCDNSRYNILEEVAKKMDLDMRKTSSLWKD QALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYR CRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQ PDPWNTHVWK Description Functional site 1) chain A residue 417 type sequence G description BINDING SITE FOR RESIDUE ACT A 860 source : AC1 2) chain A residue 587 type sequence W description BINDING SITE FOR RESIDUE ACT A 860 source : AC1 3) chain A residue 654 type sequence A description BINDING SITE FOR RESIDUE ACT A 860 source : AC1 4) chain A residue 657 type sequence S description BINDING SITE FOR RESIDUE ACT A 860 source : AC1 5) chain B residue 587 type sequence W description BINDING SITE FOR RESIDUE ACT B 861 source : AC2 6) chain B residue 649 type sequence V description BINDING SITE FOR RESIDUE ACT B 861 source : AC2 7) chain B residue 657 type sequence S description BINDING SITE FOR RESIDUE ACT B 861 source : AC2 8) chain A residue 326 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC3 9) chain A residue 331 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC3 10) chain B residue 326 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC3 11) chain B residue 331 type sequence C description BINDING SITE FOR RESIDUE ZN A 900 source : AC3 12) chain A residue 477 type sequence S description BINDING SITE FOR RESIDUE MTL A 870 source : AC4 13) chain A residue 481 type sequence R description BINDING SITE FOR RESIDUE MTL A 870 source : AC4 14) chain A residue 497 type sequence A description BINDING SITE FOR RESIDUE MTL A 870 source : AC4 15) chain A residue 498 type sequence N description BINDING SITE FOR RESIDUE MTL A 870 source : AC4 16) chain A residue 500 type sequence Q description BINDING SITE FOR RESIDUE MTL A 870 source : AC4 17) chain A residue 501 type sequence F description BINDING SITE FOR RESIDUE MTL A 870 source : AC4 18) chain A residue 569 type sequence N description BINDING SITE FOR RESIDUE MTL A 870 source : AC4 19) chain A residue 709 type sequence D description BINDING SITE FOR RESIDUE MTL A 870 source : AC4 20) chain A residue 711 type sequence W description BINDING SITE FOR RESIDUE MTL A 870 source : AC4 21) chain B residue 477 type sequence S description BINDING SITE FOR RESIDUE MTL B 871 source : AC5 22) chain B residue 497 type sequence A description BINDING SITE FOR RESIDUE MTL B 871 source : AC5 23) chain B residue 498 type sequence N description BINDING SITE FOR RESIDUE MTL B 871 source : AC5 24) chain B residue 500 type sequence Q description BINDING SITE FOR RESIDUE MTL B 871 source : AC5 25) chain B residue 501 type sequence F description BINDING SITE FOR RESIDUE MTL B 871 source : AC5 26) chain B residue 569 type sequence N description BINDING SITE FOR RESIDUE MTL B 871 source : AC5 27) chain B residue 709 type sequence D description BINDING SITE FOR RESIDUE MTL B 871 source : AC5 28) chain B residue 711 type sequence W description BINDING SITE FOR RESIDUE MTL B 871 source : AC5 29) chain A residue 409 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 30) chain A residue 415 type sequence C description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 31) chain A residue 457 type sequence S description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 32) chain A residue 584 type sequence F description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 33) chain A residue 585 type sequence S description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 34) chain A residue 586 type sequence G description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 35) chain A residue 587 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 36) chain A residue 592 type sequence E description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 37) chain A residue 678 type sequence W description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 38) chain A residue 706 type sequence Y description BINDING SITE FOR RESIDUE HEM A 750 source : AC6 39) chain A residue 334 type sequence S description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 40) chain A residue 336 type sequence M description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 41) chain A residue 596 type sequence R description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 42) chain A residue 677 type sequence V description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 43) chain A residue 678 type sequence W description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 44) chain B residue 676 type sequence W description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 45) chain B residue 691 type sequence F description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 46) chain B residue 692 type sequence H description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 47) chain B residue 693 type sequence Q description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 48) chain B residue 694 type sequence E description BINDING SITE FOR RESIDUE H4B A 760 source : AC7 49) chain A residue 478 type sequence Q description BINDING SITE FOR RESIDUE DP9 A 799 source : AC8 50) chain A residue 481 type sequence R description BINDING SITE FOR RESIDUE DP9 A 799 source : AC8 51) chain A residue 565 type sequence P description BINDING SITE FOR RESIDUE DP9 A 799 source : AC8 52) chain A residue 567 type sequence V description BINDING SITE FOR RESIDUE DP9 A 799 source : AC8 53) chain A residue 569 type sequence N description BINDING SITE FOR RESIDUE DP9 A 799 source : AC8 54) chain A residue 570 type sequence M description BINDING SITE FOR RESIDUE DP9 A 799 source : AC8 55) chain A residue 585 type sequence S description BINDING SITE FOR RESIDUE DP9 A 799 source : AC8 56) chain A residue 586 type sequence G description BINDING SITE FOR RESIDUE DP9 A 799 source : AC8 57) chain A residue 587 type sequence W description BINDING SITE FOR RESIDUE DP9 A 799 source : AC8 58) chain A residue 592 type sequence E description BINDING SITE FOR RESIDUE DP9 A 799 source : AC8 59) chain A residue 706 type sequence Y description BINDING SITE FOR RESIDUE DP9 A 799 source : AC8 60) chain B residue 409 type sequence W description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 61) chain B residue 415 type sequence C description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 62) chain B residue 457 type sequence S description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 63) chain B residue 584 type sequence F description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 64) chain B residue 585 type sequence S description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 65) chain B residue 587 type sequence W description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 66) chain B residue 592 type sequence E description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 67) chain B residue 678 type sequence W description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 68) chain B residue 706 type sequence Y description BINDING SITE FOR RESIDUE HEM B 750 source : AC9 69) chain A residue 676 type sequence W description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 70) chain A residue 691 type sequence F description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 71) chain A residue 692 type sequence H description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 72) chain A residue 693 type sequence Q description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 73) chain A residue 694 type sequence E description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 74) chain B residue 334 type sequence S description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 75) chain B residue 596 type sequence R description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 76) chain B residue 677 type sequence V description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 77) chain B residue 678 type sequence W description BINDING SITE FOR RESIDUE H4B B 761 source : BC1 78) chain B residue 478 type sequence Q description BINDING SITE FOR RESIDUE DP9 B 800 source : BC2 79) chain B residue 481 type sequence R description BINDING SITE FOR RESIDUE DP9 B 800 source : BC2 80) chain B residue 565 type sequence P description BINDING SITE FOR RESIDUE DP9 B 800 source : BC2 81) chain B residue 567 type sequence V description BINDING SITE FOR RESIDUE DP9 B 800 source : BC2 82) chain B residue 569 type sequence N description BINDING SITE FOR RESIDUE DP9 B 800 source : BC2 83) chain B residue 570 type sequence M description BINDING SITE FOR RESIDUE DP9 B 800 source : BC2 84) chain B residue 585 type sequence S description BINDING SITE FOR RESIDUE DP9 B 800 source : BC2 85) chain B residue 586 type sequence G description BINDING SITE FOR RESIDUE DP9 B 800 source : BC2 86) chain B residue 587 type sequence W description BINDING SITE FOR RESIDUE DP9 B 800 source : BC2 87) chain B residue 592 type sequence E description BINDING SITE FOR RESIDUE DP9 B 800 source : BC2 88) chain B residue 706 type sequence Y description BINDING SITE FOR RESIDUE DP9 B 800 source : BC2 89) chain A residue 334 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 90) chain B residue 334 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 91) chain B residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 92) chain B residue 587 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 93) chain B residue 588 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 94) chain B residue 592 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 95) chain B residue 677 type BINDING sequence V description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 96) chain B residue 678 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 97) chain B residue 691 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 98) chain B residue 706 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 99) chain A residue 478 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 100) chain A residue 587 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 101) chain A residue 588 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 102) chain A residue 592 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 103) chain A residue 677 type BINDING sequence V description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 104) chain A residue 678 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 105) chain A residue 691 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 106) chain A residue 706 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI1 107) chain A residue 414-421 type prosite sequence RCVGRIQW description NOS Nitric oxide synthase (NOS) signature. RCVGRIqW source prosite : PS60001 108) chain A residue 415 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI2 109) chain B residue 415 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29475 source Swiss-Prot : SWS_FT_FI2

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