eF-site ID 1zyq-A PDB Code 1zyq Chain A click to enlarge Title T7 DNA polymerase in complex with 8oG and incoming ddATP Classification TRANSFERASE/ELECTRON TRANSPORT/DNA Compound 5'-D(*CP*GP*AP*AP*AP*AP*CP*GP*AP*CP*GP*GP*CP*CP*AP*GP*TP*GP*CP*CP*AP*(DDG))-3' Source Enterobacteria phage T7 (Bacteriophage T7) (1ZYQ) Sequence A:  MIVSDIEANALLESVTKFHCGVIYDYSTAEYVSYRPSDFG AYLDALEAEVARGGLIVFHNGHKYDVPALTKLAKLQLNRE FHLPRENCIDTLVLSRLIHSNLKDTDMGLLRSGKLPGALE AWGYRLGEMKGEYKDDFKRMLEEQGEEYVDGMEWWNFNEE MMDYNVQDVVVTKALLEKLLSDKHYFPPEIDFTDVGYTTF WSESLEAVDIEHRAAWLLAKQERNGFPFDTKAIEELYVEL AARRSELLRKLTETFGSWYQPKGGTEMFCHPRTGKPLPKY PRIKTPKVGGLDTREYVAGAPYTPVEHVVFNPSSRDHIQK KLQEAGWVPTKYTDKGAPVVDDEVLEGVRVDDPEKQAAID LIKEYLMIQKRIGQSAEGDKAWLRYVAEDGKIHGSVNPNG AVTGRATHAFPNLAQIPGVRSPYGEQCRAAFGAEHHLDGI TGKPWVQAGIDASGLELRCLAHFMARFDNGEYAHEILNGD IHTKNQIAAELPTRDNAKTFIYGFLYGAGDEAIGQIVGAG KERGKELKKKFLENTPAIAALRESIQQTLVESSQWVAGEQ QVKWKRRWIKGLDGRKVHVRSPHAALNTLLQSAGALICKL WIIKTEEMLVEKGLKHGWDGDFAYMAWVHDEIQVGCRTEE IAQVVIETAQEAMRWVGDHWNFRCLLDTEGKMGPNWAICH Description Functional site 1) chain A residue 475 type sequence D description BINDING SITE FOR RESIDUE MG A 4001 source : AC1 2) chain A residue 476 type sequence A description BINDING SITE FOR RESIDUE MG A 4001 source : AC1 3) chain A residue 654 type sequence D description BINDING SITE FOR RESIDUE MG A 4001 source : AC1 4) chain A residue 475 type sequence D description BINDING SITE FOR RESIDUE MG A 4002 source : AC2 5) chain A residue 654 type sequence D description BINDING SITE FOR RESIDUE MG A 4002 source : AC2 6) chain A residue 655 type sequence E description BINDING SITE FOR RESIDUE MG A 4002 source : AC2 7) chain A residue 704 type sequence H description BINDING SITE FOR RESIDUE MG A 4002 source : AC2 8) chain A residue 5 type sequence D description BINDING SITE FOR RESIDUE MG A 4003 source : AC3 9) chain A residue 174 type sequence D description BINDING SITE FOR RESIDUE MG A 4003 source : AC3 10) chain A residue 429 type sequence R description BINDING SITE FOR RESIDUE DAD A 1024 source : AC4 11) chain A residue 475 type sequence D description BINDING SITE FOR RESIDUE DAD A 1024 source : AC4 12) chain A residue 476 type sequence A description BINDING SITE FOR RESIDUE DAD A 1024 source : AC4 13) chain A residue 477 type sequence S description BINDING SITE FOR RESIDUE DAD A 1024 source : AC4 14) chain A residue 478 type sequence G description BINDING SITE FOR RESIDUE DAD A 1024 source : AC4 15) chain A residue 479 type sequence L description BINDING SITE FOR RESIDUE DAD A 1024 source : AC4 16) chain A residue 480 type sequence E description BINDING SITE FOR RESIDUE DAD A 1024 source : AC4 17) chain A residue 506 type sequence H description BINDING SITE FOR RESIDUE DAD A 1024 source : AC4 18) chain A residue 518 type sequence R description BINDING SITE FOR RESIDUE DAD A 1024 source : AC4 19) chain A residue 522 type sequence K description BINDING SITE FOR RESIDUE DAD A 1024 source : AC4 20) chain A residue 526 type sequence Y description BINDING SITE FOR RESIDUE DAD A 1024 source : AC4 21) chain A residue 654 type sequence D description BINDING SITE FOR RESIDUE DAD A 1024 source : AC4 22) chain A residue 518-537 type prosite sequence RDNAKTFIYGFLYGAGDEAI description DNA_POLYMERASE_A DNA polymerase family A signature. RdnAKtfiYGflYgaGdeaI source prosite : PS00447 23) chain A residue 180 type ACT_SITE sequence A description Nucleophile source Swiss-Prot : SWS_FT_FI1 24) chain A residue 482 type SITE sequence R description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 25) chain A residue 660 type SITE sequence C description Deprotonates C-terminal active site Cys source Swiss-Prot : SWS_FT_FI2 26) chain A residue 528 type SITE sequence F description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3 27) chain A residue 532 type SITE sequence A description Contributes to redox potential value source Swiss-Prot : SWS_FT_FI3

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