eF-site ID 1zua-X PDB Code 1zua Chain X click to enlarge Title Crystal Structure Of AKR1B10 Complexed With NADP+ And Tolrestat Classification OXIDOREDUCTASE Compound Aldo-keto reductase family 1 member B10 Source Homo sapiens (Human) (AK1BA_HUMAN) Sequence X:  HMATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAG YRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKL WPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSG DDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGV SNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQY CHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAA KHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDF KLSDEEMATILSFNRNWRACNVLQSSHLEDYPFNAEY Description Functional site 1) chain X residue 19 type sequence G description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 2) chain X residue 20 type sequence T description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 3) chain X residue 21 type sequence W description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 4) chain X residue 22 type sequence K description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 5) chain X residue 44 type sequence D description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 6) chain X residue 49 type sequence Y description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 7) chain X residue 111 type sequence H description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 8) chain X residue 112 type sequence W description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 9) chain X residue 160 type sequence S description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 10) chain X residue 161 type sequence N description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 11) chain X residue 184 type sequence Q description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 12) chain X residue 210 type sequence Y description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 13) chain X residue 211 type sequence S description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 14) chain X residue 212 type sequence P description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 15) chain X residue 213 type sequence L description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 16) chain X residue 214 type sequence G description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 17) chain X residue 215 type sequence S description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 18) chain X residue 216 type sequence P description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 19) chain X residue 217 type sequence D description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 20) chain X residue 246 type sequence A description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 21) chain X residue 261 type sequence I description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 22) chain X residue 262 type sequence P description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 23) chain X residue 263 type sequence K description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 24) chain X residue 264 type sequence S description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 25) chain X residue 265 type sequence V description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 26) chain X residue 266 type sequence T description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 27) chain X residue 269 type sequence R description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 28) chain X residue 272 type sequence E description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 29) chain X residue 273 type sequence N description BINDING SITE FOR RESIDUE NAP X 350 source : AC1 30) chain X residue 21 type sequence W description BINDING SITE FOR RESIDUE TOL X 1320 source : AC2 31) chain X residue 49 type sequence Y description BINDING SITE FOR RESIDUE TOL X 1320 source : AC2 32) chain X residue 80 type sequence W description BINDING SITE FOR RESIDUE TOL X 1320 source : AC2 33) chain X residue 111 type sequence H description BINDING SITE FOR RESIDUE TOL X 1320 source : AC2 34) chain X residue 112 type sequence W description BINDING SITE FOR RESIDUE TOL X 1320 source : AC2 35) chain X residue 114 type sequence Q description BINDING SITE FOR RESIDUE TOL X 1320 source : AC2 36) chain X residue 116 type sequence F description BINDING SITE FOR RESIDUE TOL X 1320 source : AC2 37) chain X residue 123 type sequence F description BINDING SITE FOR RESIDUE TOL X 1320 source : AC2 38) chain X residue 150 type sequence D description BINDING SITE FOR RESIDUE TOL X 1320 source : AC2 39) chain X residue 301 type sequence V description BINDING SITE FOR RESIDUE TOL X 1320 source : AC2 40) chain X residue 303 type sequence Q description BINDING SITE FOR RESIDUE TOL X 1320 source : AC2 41) chain X residue 49 type ACT_SITE sequence Y description Proton donor => ECO:0000269|PubMed:18087047 source Swiss-Prot : SWS_FT_FI1 42) chain X residue 20 type BINDING sequence T description BINDING => ECO:0000269|PubMed:18087047 source Swiss-Prot : SWS_FT_FI2 43) chain X residue 44 type BINDING sequence D description BINDING => ECO:0000269|PubMed:18087047 source Swiss-Prot : SWS_FT_FI2 44) chain X residue 111 type BINDING sequence H description BINDING => ECO:0000269|PubMed:18087047 source Swiss-Prot : SWS_FT_FI2 45) chain X residue 160 type BINDING sequence S description BINDING => ECO:0000269|PubMed:18087047 source Swiss-Prot : SWS_FT_FI2 46) chain X residue 184 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:18087047 source Swiss-Prot : SWS_FT_FI2 47) chain X residue 210 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:18087047 source Swiss-Prot : SWS_FT_FI2 48) chain X residue 261 type BINDING sequence I description BINDING => ECO:0000269|PubMed:18087047 source Swiss-Prot : SWS_FT_FI2 49) chain X residue 78 type SITE sequence K description Lowers pKa of active site Tyr => ECO:0000250|UniProtKB:P14550 source Swiss-Prot : SWS_FT_FI3 50) chain X residue 125 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI4 51) chain X residue 263 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI4 52) chain X residue 145-162 type prosite sequence MEELVDEGLVKALGVSNF description ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. MeelvdeglVKALGVSNF source prosite : PS00062 53) chain X residue 261-276 type prosite sequence IPKSVTPARIVENIQV description ALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. IPKSVTpaRIvENiQV source prosite : PS00063 54) chain X residue 39-56 type prosite sequence GYRHIDCAYVYQNEHEVG description ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHIDCAyvyqnEheVG source prosite : PS00798

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