eF-site ID 1zsf-B PDB Code 1zsf Chain B click to enlarge Title Crystal Structure of Complex of a Hydroxyethylamine Inhibitor with HIV-1 Protease at 2.0A Resolution Classification HYDROLASE/HYDROLASE INHIBITOR Compound PROTEASE RETROPEPSIN Source Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) (POL_HV1BR) Sequence B:  PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPG RWKPKMIGGIGGFIKVRQYDQILIEIXGHKAIGTVLVGPT PVNIIGRNLLTQIGCTLNF Description Functional site 1) chain B residue 108 type sequence R description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 2) chain B residue 125 type sequence D description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 3) chain B residue 127 type sequence G description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 4) chain B residue 128 type sequence A description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 5) chain B residue 129 type sequence D description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 6) chain B residue 130 type sequence D description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 7) chain B residue 147 type sequence I description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 8) chain B residue 148 type sequence G description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 9) chain B residue 149 type sequence G description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 10) chain B residue 150 type sequence I description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 11) chain B residue 153 type sequence F description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 12) chain B residue 182 type sequence V description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 13) chain B residue 184 type sequence I description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 14) chain B residue 125 type ACT_SITE sequence D description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094, ECO:0000269|PubMed:12924029 source Swiss-Prot : SWS_FT_FI3 15) chain B residue 164 type SITE sequence I description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 16) chain B residue 164 type MOD_RES sequence I description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 17) chain B residue 199 type SITE sequence F description Cleavage; by viral protease => ECO:0000269|PubMed:2476069 source Swiss-Prot : SWS_FT_FI4

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