eF-site ID 1zsf-A
PDB Code 1zsf
Chain A

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Title Crystal Structure of Complex of a Hydroxyethylamine Inhibitor with HIV-1 Protease at 2.0A Resolution
Classification HYDROLASE/HYDROLASE INHIBITOR
Compound PROTEASE RETROPEPSIN
Source Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) (POL_HV1BR)
Sequence A:  PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPG
RWKPKMIGGIGGFIKVRQYDQILIEIXGHKAIGTVLVGPT
PVNIIGRNLLTQIGCTLNF
Description


Functional site

1) chain A
residue 25
type
sequence D
description BINDING SITE FOR RESIDUE 0ZS B 201
source : AC1

2) chain A
residue 27
type
sequence G
description BINDING SITE FOR RESIDUE 0ZS B 201
source : AC1

3) chain A
residue 28
type
sequence A
description BINDING SITE FOR RESIDUE 0ZS B 201
source : AC1

4) chain A
residue 29
type
sequence D
description BINDING SITE FOR RESIDUE 0ZS B 201
source : AC1

5) chain A
residue 30
type
sequence D
description BINDING SITE FOR RESIDUE 0ZS B 201
source : AC1

6) chain A
residue 32
type
sequence V
description BINDING SITE FOR RESIDUE 0ZS B 201
source : AC1

7) chain A
residue 47
type
sequence I
description BINDING SITE FOR RESIDUE 0ZS B 201
source : AC1

8) chain A
residue 48
type
sequence G
description BINDING SITE FOR RESIDUE 0ZS B 201
source : AC1

9) chain A
residue 49
type
sequence G
description BINDING SITE FOR RESIDUE 0ZS B 201
source : AC1

10) chain A
residue 50
type
sequence I
description BINDING SITE FOR RESIDUE 0ZS B 201
source : AC1

11) chain A
residue 53
type
sequence F
description BINDING SITE FOR RESIDUE 0ZS B 201
source : AC1

12) chain A
residue 81
type
sequence P
description BINDING SITE FOR RESIDUE 0ZS B 201
source : AC1

13) chain A
residue 82
type
sequence V
description BINDING SITE FOR RESIDUE 0ZS B 201
source : AC1

14) chain A
residue 84
type
sequence I
description BINDING SITE FOR RESIDUE 0ZS B 201
source : AC1

15) chain A
residue 22-33
type prosite
sequence ALLDTGADDTVL
description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL
source prosite : PS00141

16) chain A
residue 64
type SITE
sequence I
description Cleavage; by viral protease => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

17) chain A
residue 64
type MOD_RES
sequence I
description Phosphotyrosine; by host => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

18) chain A
residue 25
type ACT_SITE
sequence D
description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094, ECO:0000269|PubMed:12924029
source Swiss-Prot : SWS_FT_FI3

19) chain A
residue 99
type SITE
sequence F
description Cleavage; by viral protease => ECO:0000269|PubMed:2476069
source Swiss-Prot : SWS_FT_FI4


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