eF-site ID 1zpk-B PDB Code 1zpk Chain B click to enlarge Title Crystal structure of the complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2 Classification HYDROLASE/HYDROLASE INHIBITOR Compound PROTEASE RETROPEPSIN Source Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) (POL_HV1BR) Sequence B:  PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPG RWKPKMIGGIGGFIKVRQYDQILIEIXGHKVIGTVLVGPT PTNVIGRNLLTQIGCTLNF Description Functional site 1) chain B residue 123 type sequence L description BINDING SITE FOR RESIDUE 0ZS A 201 source : AC1 2) chain B residue 125 type sequence D description BINDING SITE FOR RESIDUE 0ZS A 201 source : AC1 3) chain B residue 127 type sequence G description BINDING SITE FOR RESIDUE 0ZS A 201 source : AC1 4) chain B residue 128 type sequence A description BINDING SITE FOR RESIDUE 0ZS A 201 source : AC1 5) chain B residue 129 type sequence D description BINDING SITE FOR RESIDUE 0ZS A 201 source : AC1 6) chain B residue 130 type sequence D description BINDING SITE FOR RESIDUE 0ZS A 201 source : AC1 7) chain B residue 147 type sequence I description BINDING SITE FOR RESIDUE 0ZS A 201 source : AC1 8) chain B residue 148 type sequence G description BINDING SITE FOR RESIDUE 0ZS A 201 source : AC1 9) chain B residue 149 type sequence G description BINDING SITE FOR RESIDUE 0ZS A 201 source : AC1 10) chain B residue 150 type sequence I description BINDING SITE FOR RESIDUE 0ZS A 201 source : AC1 11) chain B residue 181 type sequence P description BINDING SITE FOR RESIDUE 0ZS A 201 source : AC1 12) chain B residue 182 type sequence T description BINDING SITE FOR RESIDUE 0ZS A 201 source : AC1 13) chain B residue 173 type sequence G description BINDING SITE FOR RESIDUE CL B 501 source : AC2 14) chain B residue 174 type sequence T description BINDING SITE FOR RESIDUE CL B 501 source : AC2 15) chain B residue 188 type sequence N description BINDING SITE FOR RESIDUE CL B 501 source : AC2 16) chain B residue 130 type sequence D description BINDING SITE FOR RESIDUE NA B 502 source : AC3 17) chain B residue 164 type SITE sequence I description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 18) chain B residue 164 type MOD_RES sequence I description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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