eF-site ID 1zpk-AB
PDB Code 1zpk
Chain A, B

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Title Crystal structure of the complex of mutant HIV-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
Classification HYDROLASE/HYDROLASE INHIBITOR
Compound PROTEASE RETROPEPSIN
Source Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) (POL_HV1BR)
Sequence A:  PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPG
RWKPKMIGGIGGFIKVRQYDQILIEIXGHKVIGTVLVGPT
PTNVIGRNLLTQIGCTLNF
B:  PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPG
RWKPKMIGGIGGFIKVRQYDQILIEIXGHKVIGTVLVGPT
PTNVIGRNLLTQIGCTLNF
Description


Functional site

1) chain A
residue 8
type
sequence R
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

2) chain A
residue 23
type
sequence L
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

3) chain A
residue 25
type
sequence D
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

4) chain A
residue 27
type
sequence G
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

5) chain A
residue 28
type
sequence A
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

6) chain A
residue 29
type
sequence D
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

7) chain A
residue 30
type
sequence D
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

8) chain A
residue 47
type
sequence I
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

9) chain A
residue 48
type
sequence G
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

10) chain A
residue 49
type
sequence G
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

11) chain A
residue 50
type
sequence I
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

12) chain A
residue 53
type
sequence F
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

13) chain A
residue 81
type
sequence P
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

14) chain A
residue 82
type
sequence T
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

15) chain B
residue 123
type
sequence L
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

16) chain B
residue 125
type
sequence D
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

17) chain B
residue 127
type
sequence G
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

18) chain B
residue 128
type
sequence A
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

19) chain B
residue 129
type
sequence D
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

20) chain B
residue 130
type
sequence D
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

21) chain B
residue 147
type
sequence I
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

22) chain B
residue 148
type
sequence G
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

23) chain B
residue 149
type
sequence G
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

24) chain B
residue 150
type
sequence I
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

25) chain B
residue 181
type
sequence P
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

26) chain B
residue 182
type
sequence T
description BINDING SITE FOR RESIDUE 0ZS A 201
source : AC1

27) chain B
residue 173
type
sequence G
description BINDING SITE FOR RESIDUE CL B 501
source : AC2

28) chain B
residue 174
type
sequence T
description BINDING SITE FOR RESIDUE CL B 501
source : AC2

29) chain B
residue 188
type
sequence N
description BINDING SITE FOR RESIDUE CL B 501
source : AC2

30) chain B
residue 130
type
sequence D
description BINDING SITE FOR RESIDUE NA B 502
source : AC3

31) chain A
residue 22-33
type prosite
sequence ALLDTGADDTVL
description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL
source prosite : PS00141

32) chain A
residue 64
type SITE
sequence I
description Cleavage; by viral protease => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

33) chain B
residue 164
type SITE
sequence I
description Cleavage; by viral protease => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

34) chain A
residue 64
type MOD_RES
sequence I
description Phosphotyrosine; by host => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

35) chain B
residue 164
type MOD_RES
sequence I
description Phosphotyrosine; by host => ECO:0000250
source Swiss-Prot : SWS_FT_FI2


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