eF-site ID 1zmx-ABCDEFGH PDB Code 1zmx Chain A, B, C, D, E, F, G, H click to enlarge Title Crystal structure of D. melanogaster deoxyribonucleoside kinase N64D mutant in complex with thymidine Classification TRANSFERASE Compound Deoxynucleoside kinase Source Drosophila melanogaster (Fruit fly) (DNK_DROME) Sequence A:  TKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLT EPVEKWRNVNGVDLLELMYKDPKKWAMPFQSYVTLTMLQS HTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNT LEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRVPLK YLQELHELHEDWLIHQRRPQSCKVLVLDAD B:  TKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLT EPVEKWRNVNGVDLLELMYKDPKKWAMPFQSYVTLTMLQS HTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNT LEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRVPLK YLQELHELHEDWLIHQCKVLVLDAD C:  TKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLT EPVEKWRNVNGVDLLELMYKDPKKWAMPFQSYVTLTMLQS HTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNT LEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRCVPL KYLQELHELHEDWLIHQRRPQSCKVLVLDAD D:  TKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLT EPVEKWRNVNGVDLLELMYKDPKKWAMPFQSYVTLTMLQS HTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNT LEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRVPLK YLQELHELHEDWLIHQCKVLVLDAD E:  TKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLT EPVEKWRNVNGVDLLELMYKDPKKWAMPFQSYVTLTMLQS HTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNT LEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRVPLK YLQELHELHEDWLIHQRRPQSCKVLVLDAD F:  TKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLT EPVEKWRNVNGVDLLELMYKDPKKWAMPFQSYVTLTMLQS HTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNT LEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRSCVP LKYLQELHELHEDWLIHQCKVLVLDAD G:  TKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLT EPVEKWRNVNGVDLLELMYKDPKKWAMPFQSYVTLTMLQS HTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNT LEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRVPLK YLQELHELHEDWLIHQRRPQSCKVLVLDA H:  TKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLT EPVEKWRNVNGVDLLELMYKDPKKWAMPFQSYVTLTMLQS HTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNT LEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRCVPL KYLQELHELHEDWLIHQCKVLVLDA Description Functional site 1) chain A residue 28 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1300 source : AC1 2) chain A residue 30 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1300 source : AC1 3) chain A residue 31 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1300 source : AC1 4) chain A residue 32 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1300 source : AC1 5) chain A residue 33 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1300 source : AC1 6) chain A residue 34 type sequence T description BINDING SITE FOR RESIDUE SO4 A 1300 source : AC1 7) chain A residue 167 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1300 source : AC1 8) chain B residue 28 type sequence N description BINDING SITE FOR RESIDUE SO4 B 1301 source : AC2 9) chain B residue 30 type sequence G description BINDING SITE FOR RESIDUE SO4 B 1301 source : AC2 10) chain B residue 31 type sequence S description BINDING SITE FOR RESIDUE SO4 B 1301 source : AC2 11) chain B residue 32 type sequence G description BINDING SITE FOR RESIDUE SO4 B 1301 source : AC2 12) chain B residue 33 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1301 source : AC2 13) chain B residue 34 type sequence T description BINDING SITE FOR RESIDUE SO4 B 1301 source : AC2 14) chain B residue 167 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1301 source : AC2 15) chain G residue 28 type sequence N description BINDING SITE FOR RESIDUE SO4 G 1302 source : AC3 16) chain G residue 30 type sequence G description BINDING SITE FOR RESIDUE SO4 G 1302 source : AC3 17) chain G residue 31 type sequence S description BINDING SITE FOR RESIDUE SO4 G 1302 source : AC3 18) chain G residue 32 type sequence G description BINDING SITE FOR RESIDUE SO4 G 1302 source : AC3 19) chain G residue 33 type sequence K description BINDING SITE FOR RESIDUE SO4 G 1302 source : AC3 20) chain G residue 34 type sequence T description BINDING SITE FOR RESIDUE SO4 G 1302 source : AC3 21) chain G residue 167 type sequence R description BINDING SITE FOR RESIDUE SO4 G 1302 source : AC3 22) chain H residue 29 type sequence I description BINDING SITE FOR RESIDUE SO4 H 1303 source : AC4 23) chain H residue 30 type sequence G description BINDING SITE FOR RESIDUE SO4 H 1303 source : AC4 24) chain H residue 31 type sequence S description BINDING SITE FOR RESIDUE SO4 H 1303 source : AC4 25) chain H residue 32 type sequence G description BINDING SITE FOR RESIDUE SO4 H 1303 source : AC4 26) chain H residue 33 type sequence K description BINDING SITE FOR RESIDUE SO4 H 1303 source : AC4 27) chain H residue 34 type sequence T description BINDING SITE FOR RESIDUE SO4 H 1303 source : AC4 28) chain E residue 28 type sequence N description BINDING SITE FOR RESIDUE SO4 E 1304 source : AC5 29) chain E residue 30 type sequence G description BINDING SITE FOR RESIDUE SO4 E 1304 source : AC5 30) chain E residue 31 type sequence S description BINDING SITE FOR RESIDUE SO4 E 1304 source : AC5 31) chain E residue 32 type sequence G description BINDING SITE FOR RESIDUE SO4 E 1304 source : AC5 32) chain E residue 33 type sequence K description BINDING SITE FOR RESIDUE SO4 E 1304 source : AC5 33) chain E residue 34 type sequence T description BINDING SITE FOR RESIDUE SO4 E 1304 source : AC5 34) chain E residue 167 type sequence R description BINDING SITE FOR RESIDUE SO4 E 1304 source : AC5 35) chain F residue 28 type sequence N description BINDING SITE FOR RESIDUE SO4 F 1305 source : AC6 36) chain F residue 30 type sequence G description BINDING SITE FOR RESIDUE SO4 F 1305 source : AC6 37) chain F residue 31 type sequence S description BINDING SITE FOR RESIDUE SO4 F 1305 source : AC6 38) chain F residue 32 type sequence G description BINDING SITE FOR RESIDUE SO4 F 1305 source : AC6 39) chain F residue 33 type sequence K description BINDING SITE FOR RESIDUE SO4 F 1305 source : AC6 40) chain F residue 34 type sequence T description BINDING SITE FOR RESIDUE SO4 F 1305 source : AC6 41) chain F residue 167 type sequence R description BINDING SITE FOR RESIDUE SO4 F 1305 source : AC6 42) chain C residue 28 type sequence N description BINDING SITE FOR RESIDUE SO4 C 1306 source : AC7 43) chain C residue 30 type sequence G description BINDING SITE FOR RESIDUE SO4 C 1306 source : AC7 44) chain C residue 31 type sequence S description BINDING SITE FOR RESIDUE SO4 C 1306 source : AC7 45) chain C residue 32 type sequence G description BINDING SITE FOR RESIDUE SO4 C 1306 source : AC7 46) chain C residue 33 type sequence K description BINDING SITE FOR RESIDUE SO4 C 1306 source : AC7 47) chain C residue 34 type sequence T description BINDING SITE FOR RESIDUE SO4 C 1306 source : AC7 48) chain C residue 167 type sequence R description BINDING SITE FOR RESIDUE SO4 C 1306 source : AC7 49) chain D residue 28 type sequence N description BINDING SITE FOR RESIDUE SO4 D 1307 source : AC8 50) chain D residue 30 type sequence G description BINDING SITE FOR RESIDUE SO4 D 1307 source : AC8 51) chain D residue 31 type sequence S description BINDING SITE FOR RESIDUE SO4 D 1307 source : AC8 52) chain D residue 32 type sequence G description BINDING SITE FOR RESIDUE SO4 D 1307 source : AC8 53) chain D residue 33 type sequence K description BINDING SITE FOR RESIDUE SO4 D 1307 source : AC8 54) chain D residue 34 type sequence T description BINDING SITE FOR RESIDUE SO4 D 1307 source : AC8 55) chain D residue 167 type sequence R description BINDING SITE FOR RESIDUE SO4 D 1307 source : AC8 56) chain A residue 29 type sequence I description BINDING SITE FOR RESIDUE THM A 1400 source : AC9 57) chain A residue 52 type sequence E description BINDING SITE FOR RESIDUE THM A 1400 source : AC9 58) chain A residue 57 type sequence W description BINDING SITE FOR RESIDUE THM A 1400 source : AC9 59) chain A residue 70 type sequence Y description BINDING SITE FOR RESIDUE THM A 1400 source : AC9 60) chain A residue 80 type sequence F description BINDING SITE FOR RESIDUE THM A 1400 source : AC9 61) chain A residue 81 type sequence Q description BINDING SITE FOR RESIDUE THM A 1400 source : AC9 62) chain A residue 84 type sequence V description BINDING SITE FOR RESIDUE THM A 1400 source : AC9 63) chain A residue 88 type sequence M description BINDING SITE FOR RESIDUE THM A 1400 source : AC9 64) chain A residue 105 type sequence R description BINDING SITE FOR RESIDUE THM A 1400 source : AC9 65) chain A residue 110 type sequence A description BINDING SITE FOR RESIDUE THM A 1400 source : AC9 66) chain A residue 114 type sequence F description BINDING SITE FOR RESIDUE THM A 1400 source : AC9 67) chain B residue 29 type sequence I description BINDING SITE FOR RESIDUE THM B 1401 source : BC1 68) chain B residue 52 type sequence E description BINDING SITE FOR RESIDUE THM B 1401 source : BC1 69) chain B residue 57 type sequence W description BINDING SITE FOR RESIDUE THM B 1401 source : BC1 70) chain B residue 70 type sequence Y description BINDING SITE FOR RESIDUE THM B 1401 source : BC1 71) chain B residue 80 type sequence F description BINDING SITE FOR RESIDUE THM B 1401 source : BC1 72) chain B residue 81 type sequence Q description BINDING SITE FOR RESIDUE THM B 1401 source : BC1 73) chain B residue 105 type sequence R description BINDING SITE FOR RESIDUE THM B 1401 source : BC1 74) chain B residue 110 type sequence A description BINDING SITE FOR RESIDUE THM B 1401 source : BC1 75) chain B residue 114 type sequence F description BINDING SITE FOR RESIDUE THM B 1401 source : BC1 76) chain G residue 29 type sequence I description BINDING SITE FOR RESIDUE THM G 1402 source : BC2 77) chain G residue 52 type sequence E description BINDING SITE FOR RESIDUE THM G 1402 source : BC2 78) chain G residue 57 type sequence W description BINDING SITE FOR RESIDUE THM G 1402 source : BC2 79) chain G residue 70 type sequence Y description BINDING SITE FOR RESIDUE THM G 1402 source : BC2 80) chain G residue 80 type sequence F description BINDING SITE FOR RESIDUE THM G 1402 source : BC2 81) chain G residue 81 type sequence Q description BINDING SITE FOR RESIDUE THM G 1402 source : BC2 82) chain G residue 105 type sequence R description BINDING SITE FOR RESIDUE THM G 1402 source : BC2 83) chain G residue 110 type sequence A description BINDING SITE FOR RESIDUE THM G 1402 source : BC2 84) chain G residue 114 type sequence F description BINDING SITE FOR RESIDUE THM G 1402 source : BC2 85) chain H residue 52 type sequence E description BINDING SITE FOR RESIDUE THM H 1403 source : BC3 86) chain H residue 57 type sequence W description BINDING SITE FOR RESIDUE THM H 1403 source : BC3 87) chain H residue 70 type sequence Y description BINDING SITE FOR RESIDUE THM H 1403 source : BC3 88) chain H residue 80 type sequence F description BINDING SITE FOR RESIDUE THM H 1403 source : BC3 89) chain H residue 81 type sequence Q description BINDING SITE FOR RESIDUE THM H 1403 source : BC3 90) chain H residue 105 type sequence R description BINDING SITE FOR RESIDUE THM H 1403 source : BC3 91) chain H residue 110 type sequence A description BINDING SITE FOR RESIDUE THM H 1403 source : BC3 92) chain H residue 114 type sequence F description BINDING SITE FOR RESIDUE THM H 1403 source : BC3 93) chain E residue 29 type sequence I description BINDING SITE FOR RESIDUE THM E 1404 source : BC4 94) chain E residue 52 type sequence E description BINDING SITE FOR RESIDUE THM E 1404 source : BC4 95) chain E residue 57 type sequence W description BINDING SITE FOR RESIDUE THM E 1404 source : BC4 96) chain E residue 70 type sequence Y description BINDING SITE FOR RESIDUE THM E 1404 source : BC4 97) chain E residue 80 type sequence F description BINDING SITE FOR RESIDUE THM E 1404 source : BC4 98) chain E residue 81 type sequence Q description BINDING SITE FOR RESIDUE THM E 1404 source : BC4 99) chain E residue 84 type sequence V description BINDING SITE FOR RESIDUE THM E 1404 source : BC4 100) chain E residue 105 type sequence R description BINDING SITE FOR RESIDUE THM E 1404 source : BC4 101) chain E residue 110 type sequence A description BINDING SITE FOR RESIDUE THM E 1404 source : BC4 102) chain E residue 114 type sequence F description BINDING SITE FOR RESIDUE THM E 1404 source : BC4 103) chain F residue 29 type sequence I description BINDING SITE FOR RESIDUE THM F 1405 source : BC5 104) chain F residue 52 type sequence E description BINDING SITE FOR RESIDUE THM F 1405 source : BC5 105) chain F residue 57 type sequence W description BINDING SITE FOR RESIDUE THM F 1405 source : BC5 106) chain F residue 70 type sequence Y description BINDING SITE FOR RESIDUE THM F 1405 source : BC5 107) chain F residue 80 type sequence F description BINDING SITE FOR RESIDUE THM F 1405 source : BC5 108) chain F residue 81 type sequence Q description BINDING SITE FOR RESIDUE THM F 1405 source : BC5 109) chain F residue 84 type sequence V description BINDING SITE FOR RESIDUE THM F 1405 source : BC5 110) chain F residue 105 type sequence R description BINDING SITE FOR RESIDUE THM F 1405 source : BC5 111) chain F residue 110 type sequence A description BINDING SITE FOR RESIDUE THM F 1405 source : BC5 112) chain F residue 114 type sequence F description BINDING SITE FOR RESIDUE THM F 1405 source : BC5 113) chain C residue 29 type sequence I description BINDING SITE FOR RESIDUE THM C 1406 source : BC6 114) chain C residue 52 type sequence E description BINDING SITE FOR RESIDUE THM C 1406 source : BC6 115) chain C residue 57 type sequence W description BINDING SITE FOR RESIDUE THM C 1406 source : BC6 116) chain C residue 66 type sequence L description BINDING SITE FOR RESIDUE THM C 1406 source : BC6 117) chain C residue 70 type sequence Y description BINDING SITE FOR RESIDUE THM C 1406 source : BC6 118) chain C residue 80 type sequence F description BINDING SITE FOR RESIDUE THM C 1406 source : BC6 119) chain C residue 81 type sequence Q description BINDING SITE FOR RESIDUE THM C 1406 source : BC6 120) chain C residue 84 type sequence V description BINDING SITE FOR RESIDUE THM C 1406 source : BC6 121) chain C residue 105 type sequence R description BINDING SITE FOR RESIDUE THM C 1406 source : BC6 122) chain C residue 110 type sequence A description BINDING SITE FOR RESIDUE THM C 1406 source : BC6 123) chain C residue 114 type sequence F description BINDING SITE FOR RESIDUE THM C 1406 source : BC6 124) chain D residue 29 type sequence I description BINDING SITE FOR RESIDUE THM D 1407 source : BC7 125) chain D residue 52 type sequence E description BINDING SITE FOR RESIDUE THM D 1407 source : BC7 126) chain D residue 57 type sequence W description BINDING SITE FOR RESIDUE THM D 1407 source : BC7 127) chain D residue 70 type sequence Y description BINDING SITE FOR RESIDUE THM D 1407 source : BC7 128) chain D residue 80 type sequence F description BINDING SITE FOR RESIDUE THM D 1407 source : BC7 129) chain D residue 81 type sequence Q description BINDING SITE FOR RESIDUE THM D 1407 source : BC7 130) chain D residue 84 type sequence V description BINDING SITE FOR RESIDUE THM D 1407 source : BC7 131) chain D residue 105 type sequence R description BINDING SITE FOR RESIDUE THM D 1407 source : BC7 132) chain D residue 110 type sequence A description BINDING SITE FOR RESIDUE THM D 1407 source : BC7 133) chain D residue 114 type sequence F description BINDING SITE FOR RESIDUE THM D 1407 source : BC7 134) chain D residue 118 type sequence M description BINDING SITE FOR RESIDUE THM D 1407 source : BC7 135) chain A residue 104 type ACT_SITE sequence E description Proton acceptor => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 136) chain B residue 104 type ACT_SITE sequence E description Proton acceptor => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 137) chain C residue 104 type ACT_SITE sequence E description Proton acceptor => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 138) chain D residue 104 type ACT_SITE sequence E description Proton acceptor => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 139) chain E residue 104 type ACT_SITE sequence E description Proton acceptor => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 140) chain F residue 104 type ACT_SITE sequence E description Proton acceptor => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 141) chain G residue 104 type ACT_SITE sequence E description Proton acceptor => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 142) chain H residue 104 type ACT_SITE sequence E description Proton acceptor => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 143) chain A residue 27 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 144) chain B residue 27 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 145) chain C residue 27 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 146) chain D residue 27 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 147) chain E residue 27 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 148) chain F residue 27 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 149) chain G residue 27 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 150) chain H residue 27 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 151) chain A residue 52 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 152) chain C residue 52 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 153) chain C residue 70 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI3 154) chain C residue 81 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI3 155) chain C residue 105 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 156) chain D residue 52 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 157) chain D residue 70 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI3 158) chain D residue 81 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI3 159) chain D residue 105 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 160) chain A residue 70 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI3 161) chain E residue 52 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 162) chain E residue 70 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI3 163) chain E residue 81 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI3 164) chain E residue 105 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 165) chain F residue 52 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 166) chain F residue 70 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI3 167) chain F residue 81 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI3 168) chain F residue 105 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 169) chain A residue 81 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI3 170) chain G residue 52 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 171) chain G residue 70 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI3 172) chain G residue 81 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI3 173) chain G residue 105 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 174) chain H residue 52 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 175) chain H residue 70 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI3 176) chain H residue 81 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI3 177) chain H residue 105 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 178) chain A residue 105 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 179) chain B residue 52 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 180) chain B residue 70 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI3 181) chain B residue 81 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI3 182) chain B residue 105 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3

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