eF-site ID 1zm7-ABCD PDB Code 1zm7 Chain A, B, C, D click to enlarge Title Crystal structure of D. melanogaster deoxyribonucleoside kinase mutant N64D in complex with dTTP Classification TRANSFERASE Compound Deoxynucleoside kinase Source Drosophila melanogaster (Fruit fly) (DNK_DROME) Sequence A:  TKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLT EPVEKWRNVNGVDLLELMYKDPKKWAMPFQSYVTLTMLQS HTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNT LEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRARSE ESCVPLKYLQELHELHEDWLIHQRRPQSCKVLVLDAD B:  TKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLT EPVEKWRNVNGVDLLELMYKDPKKWAMPFQSYVTLTMLQS HTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNT LEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRARSE ESCVPLKYLQELHELHEDWLIHQRRPQSCKVLVLDADL C:  TKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLT EPVEKWRNVNGVDLLELMYKDPKKWAMPFQSYVTLTMLQS HTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNT LEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRARSE ESCVPLKYLQELHELHEDWLIHQRRPQSCKVLVLDADL D:  TKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLT EPVEKWRNVNGVDLLELMYKDPKKWAMPFQSYVTLTMLQS HTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNT LEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRARSE ESCVPLKYLQELHELHEDWLIHQRRPQSCKVLVLDAD Description Functional site 1) chain D residue 34 type sequence T description BINDING SITE FOR RESIDUE MG D 400 source : AC1 2) chain D residue 52 type sequence E description BINDING SITE FOR RESIDUE MG D 400 source : AC1 3) chain D residue 104 type sequence E description BINDING SITE FOR RESIDUE MG D 400 source : AC1 4) chain D residue 169 type sequence R description BINDING SITE FOR RESIDUE MG D 400 source : AC1 5) chain A residue 29 type sequence I description BINDING SITE FOR RESIDUE TTP A 300 source : AC2 6) chain A residue 30 type sequence G description BINDING SITE FOR RESIDUE TTP A 300 source : AC2 7) chain A residue 31 type sequence S description BINDING SITE FOR RESIDUE TTP A 300 source : AC2 8) chain A residue 32 type sequence G description BINDING SITE FOR RESIDUE TTP A 300 source : AC2 9) chain A residue 33 type sequence K description BINDING SITE FOR RESIDUE TTP A 300 source : AC2 10) chain A residue 34 type sequence T description BINDING SITE FOR RESIDUE TTP A 300 source : AC2 11) chain A residue 52 type sequence E description BINDING SITE FOR RESIDUE TTP A 300 source : AC2 12) chain A residue 57 type sequence W description BINDING SITE FOR RESIDUE TTP A 300 source : AC2 13) chain A residue 66 type sequence L description BINDING SITE FOR RESIDUE TTP A 300 source : AC2 14) chain A residue 69 type sequence M description BINDING SITE FOR RESIDUE TTP A 300 source : AC2 15) chain A residue 70 type sequence Y description BINDING SITE FOR RESIDUE TTP A 300 source : AC2 16) chain A residue 80 type sequence F description BINDING SITE FOR RESIDUE TTP A 300 source : AC2 17) chain A residue 81 type sequence Q description BINDING SITE FOR RESIDUE TTP A 300 source : AC2 18) chain A residue 84 type sequence V description BINDING SITE FOR RESIDUE TTP A 300 source : AC2 19) chain A residue 104 type sequence E description BINDING SITE FOR RESIDUE TTP A 300 source : AC2 20) chain A residue 105 type sequence R description BINDING SITE FOR RESIDUE TTP A 300 source : AC2 21) chain A residue 110 type sequence A description BINDING SITE FOR RESIDUE TTP A 300 source : AC2 22) chain A residue 114 type sequence F description BINDING SITE FOR RESIDUE TTP A 300 source : AC2 23) chain A residue 118 type sequence M description BINDING SITE FOR RESIDUE TTP A 300 source : AC2 24) chain A residue 167 type sequence R description BINDING SITE FOR RESIDUE TTP A 300 source : AC2 25) chain A residue 169 type sequence R description BINDING SITE FOR RESIDUE TTP A 300 source : AC2 26) chain A residue 172 type sequence E description BINDING SITE FOR RESIDUE TTP A 300 source : AC2 27) chain B residue 28 type sequence N description BINDING SITE FOR RESIDUE TTP B 301 source : AC3 28) chain B residue 29 type sequence I description BINDING SITE FOR RESIDUE TTP B 301 source : AC3 29) chain B residue 30 type sequence G description BINDING SITE FOR RESIDUE TTP B 301 source : AC3 30) chain B residue 31 type sequence S description BINDING SITE FOR RESIDUE TTP B 301 source : AC3 31) chain B residue 32 type sequence G description BINDING SITE FOR RESIDUE TTP B 301 source : AC3 32) chain B residue 33 type sequence K description BINDING SITE FOR RESIDUE TTP B 301 source : AC3 33) chain B residue 34 type sequence T description BINDING SITE FOR RESIDUE TTP B 301 source : AC3 34) chain B residue 52 type sequence E description BINDING SITE FOR RESIDUE TTP B 301 source : AC3 35) chain B residue 57 type sequence W description BINDING SITE FOR RESIDUE TTP B 301 source : AC3 36) chain B residue 69 type sequence M description BINDING SITE FOR RESIDUE TTP B 301 source : AC3 37) chain B residue 70 type sequence Y description BINDING SITE FOR RESIDUE TTP B 301 source : AC3 38) chain B residue 80 type sequence F description BINDING SITE FOR RESIDUE TTP B 301 source : AC3 39) chain B residue 81 type sequence Q description BINDING SITE FOR RESIDUE TTP B 301 source : AC3 40) chain B residue 84 type sequence V description BINDING SITE FOR RESIDUE TTP B 301 source : AC3 41) chain B residue 104 type sequence E description BINDING SITE FOR RESIDUE TTP B 301 source : AC3 42) chain B residue 105 type sequence R description BINDING SITE FOR RESIDUE TTP B 301 source : AC3 43) chain B residue 110 type sequence A description BINDING SITE FOR RESIDUE TTP B 301 source : AC3 44) chain B residue 114 type sequence F description BINDING SITE FOR RESIDUE TTP B 301 source : AC3 45) chain B residue 167 type sequence R description BINDING SITE FOR RESIDUE TTP B 301 source : AC3 46) chain B residue 169 type sequence R description BINDING SITE FOR RESIDUE TTP B 301 source : AC3 47) chain B residue 172 type sequence E description BINDING SITE FOR RESIDUE TTP B 301 source : AC3 48) chain C residue 29 type sequence I description BINDING SITE FOR RESIDUE TTP C 302 source : AC4 49) chain C residue 30 type sequence G description BINDING SITE FOR RESIDUE TTP C 302 source : AC4 50) chain C residue 31 type sequence S description BINDING SITE FOR RESIDUE TTP C 302 source : AC4 51) chain C residue 32 type sequence G description BINDING SITE FOR RESIDUE TTP C 302 source : AC4 52) chain C residue 33 type sequence K description BINDING SITE FOR RESIDUE TTP C 302 source : AC4 53) chain C residue 34 type sequence T description BINDING SITE FOR RESIDUE TTP C 302 source : AC4 54) chain C residue 52 type sequence E description BINDING SITE FOR RESIDUE TTP C 302 source : AC4 55) chain C residue 57 type sequence W description BINDING SITE FOR RESIDUE TTP C 302 source : AC4 56) chain C residue 69 type sequence M description BINDING SITE FOR RESIDUE TTP C 302 source : AC4 57) chain C residue 70 type sequence Y description BINDING SITE FOR RESIDUE TTP C 302 source : AC4 58) chain C residue 80 type sequence F description BINDING SITE FOR RESIDUE TTP C 302 source : AC4 59) chain C residue 81 type sequence Q description BINDING SITE FOR RESIDUE TTP C 302 source : AC4 60) chain C residue 84 type sequence V description BINDING SITE FOR RESIDUE TTP C 302 source : AC4 61) chain C residue 104 type sequence E description BINDING SITE FOR RESIDUE TTP C 302 source : AC4 62) chain C residue 105 type sequence R description BINDING SITE FOR RESIDUE TTP C 302 source : AC4 63) chain C residue 110 type sequence A description BINDING SITE FOR RESIDUE TTP C 302 source : AC4 64) chain C residue 114 type sequence F description BINDING SITE FOR RESIDUE TTP C 302 source : AC4 65) chain C residue 118 type sequence M description BINDING SITE FOR RESIDUE TTP C 302 source : AC4 66) chain C residue 167 type sequence R description BINDING SITE FOR RESIDUE TTP C 302 source : AC4 67) chain C residue 169 type sequence R description BINDING SITE FOR RESIDUE TTP C 302 source : AC4 68) chain C residue 172 type sequence E description BINDING SITE FOR RESIDUE TTP C 302 source : AC4 69) chain D residue 29 type sequence I description BINDING SITE FOR RESIDUE TTP D 303 source : AC5 70) chain D residue 30 type sequence G description BINDING SITE FOR RESIDUE TTP D 303 source : AC5 71) chain D residue 31 type sequence S description BINDING SITE FOR RESIDUE TTP D 303 source : AC5 72) chain D residue 32 type sequence G description BINDING SITE FOR RESIDUE TTP D 303 source : AC5 73) chain D residue 33 type sequence K description BINDING SITE FOR RESIDUE TTP D 303 source : AC5 74) chain D residue 34 type sequence T description BINDING SITE FOR RESIDUE TTP D 303 source : AC5 75) chain D residue 52 type sequence E description BINDING SITE FOR RESIDUE TTP D 303 source : AC5 76) chain D residue 57 type sequence W description BINDING SITE FOR RESIDUE TTP D 303 source : AC5 77) chain D residue 66 type sequence L description BINDING SITE FOR RESIDUE TTP D 303 source : AC5 78) chain D residue 69 type sequence M description BINDING SITE FOR RESIDUE TTP D 303 source : AC5 79) chain D residue 70 type sequence Y description BINDING SITE FOR RESIDUE TTP D 303 source : AC5 80) chain D residue 80 type sequence F description BINDING SITE FOR RESIDUE TTP D 303 source : AC5 81) chain D residue 81 type sequence Q description BINDING SITE FOR RESIDUE TTP D 303 source : AC5 82) chain D residue 84 type sequence V description BINDING SITE FOR RESIDUE TTP D 303 source : AC5 83) chain D residue 104 type sequence E description BINDING SITE FOR RESIDUE TTP D 303 source : AC5 84) chain D residue 105 type sequence R description BINDING SITE FOR RESIDUE TTP D 303 source : AC5 85) chain D residue 110 type sequence A description BINDING SITE FOR RESIDUE TTP D 303 source : AC5 86) chain D residue 114 type sequence F description BINDING SITE FOR RESIDUE TTP D 303 source : AC5 87) chain D residue 118 type sequence M description BINDING SITE FOR RESIDUE TTP D 303 source : AC5 88) chain D residue 167 type sequence R description BINDING SITE FOR RESIDUE TTP D 303 source : AC5 89) chain D residue 169 type sequence R description BINDING SITE FOR RESIDUE TTP D 303 source : AC5 90) chain D residue 172 type sequence E description BINDING SITE FOR RESIDUE TTP D 303 source : AC5 91) chain A residue 104 type ACT_SITE sequence E description Proton acceptor => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 92) chain B residue 104 type ACT_SITE sequence E description Proton acceptor => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 93) chain C residue 104 type ACT_SITE sequence E description Proton acceptor => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 94) chain D residue 104 type ACT_SITE sequence E description Proton acceptor => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 95) chain A residue 27 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 96) chain B residue 27 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 97) chain C residue 27 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 98) chain D residue 27 type BINDING sequence G description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 99) chain A residue 52 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 100) chain B residue 172 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 101) chain C residue 52 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 102) chain C residue 70 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI3 103) chain C residue 81 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI3 104) chain C residue 105 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 105) chain C residue 172 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 106) chain D residue 52 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 107) chain D residue 70 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI3 108) chain D residue 81 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI3 109) chain D residue 105 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 110) chain A residue 70 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI3 111) chain D residue 172 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 112) chain A residue 81 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI3 113) chain A residue 105 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 114) chain A residue 172 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 115) chain B residue 52 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 116) chain B residue 70 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI3 117) chain B residue 81 type BINDING sequence Q description source Swiss-Prot : SWS_FT_FI3 118) chain B residue 105 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3

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