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eF-site ID
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1zla-ABCDEFGHK |
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PDB Code
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1zla |
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Chain
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A, B, C, D, E, F, G, H, K |
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click to enlarge
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Title
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X-ray Structure of a Kaposi's sarcoma herpesvirus LANA peptide bound to the nucleosomal core |
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Classification
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STRUCTURAL PROTEIN/DNA |
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Compound
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Palindromic 146bp Human alpha-Satellite DNA fragment |
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Source
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(1ZLA) |
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Sequence
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A: |
PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQD
FKTDLRFQSSAVMALQEASEAYLVALFEDTNLCAIHAKRV
HIMPKDIQLARRIRGERA
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| B: |
DNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLE
NVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG
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| C: |
AKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAA
VLEYLTAEILELAGNWERDNKKTRIIPRHLQLAVRNDEEL
NKLLGRVTIAQGGVLPNIQSVLLPKKT
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| D: |
RKESYAIYVYKVLKQVHPDTGISSKAMSIMNSFVNDVFER
IAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVS
EGTKAVTKYTSAK
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| E: |
PHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQD
FKTDLRFQSSAVMALQEASEAYLVALFEDTNLCAIHAKRV
HIMPKDIQLARRIRGERA
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| F: |
RKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVL
KVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLY
GFGG
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| G: |
AKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAA
VLEYLTAEILELAGNWERDNKKTRIIPRHLQLAVRNDEEL
NKLLGRVTIAQGGVLPNIQSVLLPKK
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| H: |
RKESYAIYVYKVLKQVHPDTGISSKAMSIMNSFVNDVFER
IAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVS
EGTKAVTKYTSAK
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| K: |
PGMRLRSGRSTGAP
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Description
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(1) |
Histone H3, H4, H2A, H2B/LANA Peptide/DNA
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Functional site
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1)
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chain |
A |
| residue |
466-474 |
| type |
prosite |
| ligand |
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| sequence |
PFQRLVREI
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| description |
Histone H3 signature 2.P-F-x-[RA]-L-[VA]-[KRQ]-[DEG]-[IV].
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| source |
prosite : PS00959
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2)
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chain |
E |
| residue |
666-674 |
| type |
prosite |
| ligand |
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| sequence |
PFQRLVREI
|
| description |
Histone H3 signature 2.P-F-x-[RA]-L-[VA]-[KRQ]-[DEG]-[IV].
|
| source |
prosite : PS00959
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|
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3)
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chain |
C |
| residue |
821-827 |
| type |
prosite |
| ligand |
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| sequence |
AGLQFPV
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| description |
Histone H2A signature.[AC]-G-L-x-F-P-V.
|
| source |
prosite : PS00046
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4)
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chain |
G |
| residue |
1021-1027 |
| type |
prosite |
| ligand |
|
| sequence |
AGLQFPV
|
| description |
Histone H2A signature.[AC]-G-L-x-F-P-V.
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| source |
prosite : PS00046
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5)
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chain |
D |
| residue |
1289-1311 |
| type |
prosite |
| ligand |
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| sequence |
REIQTAVRLLLPGELAKHAVSEG
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| description |
Histone H2B signature.[KR]-E-[LIVM]-[EQ]-T-x(2)-[KR]-x-[LIVM](2)-x-[PAG]-[DE]-L-x-[KR]-H-A-[LIVM]-[STA]-E-G.
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| source |
prosite : PS00357
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6)
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chain |
H |
| residue |
1489-1511 |
| type |
prosite |
| ligand |
|
| sequence |
REIQTAVRLLLPGELAKHAVSEG
|
| description |
Histone H2B signature.[KR]-E-[LIVM]-[EQ]-T-x(2)-[KR]-x-[LIVM](2)-x-[PAG]-[DE]-L-x-[KR]-H-A-[LIVM]-[STA]-E-G.
|
| source |
prosite : PS00357
|
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