eF-site ID 1zgl-ABCDEFGHIJKLMPQRSTUV PDB Code 1zgl Chain A, B, C, D, E, F, G, H, I, J, K, L, M, P, Q, R, S, T, U, V click to enlarge Title Crystal structure of 3A6 TCR bound to MBP/HLA-DR2a Classification IMMUNE SYSTEM Compound HLA class II histocompatibility antigen, DR alpha chain Source (TCB_HUMAN) Sequence A:  EHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVW RLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPIT NVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLR NGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDC RVEHWGLDEPLLKHWEFD B:  GDTRPRFLQQDKYECHFFNGTERVRFLHRDIYNQEEDLRF DSDVGEYRAVTELGRPDAEYWNSQKDFLEDRRAAVDTYCR HNYGVGESFTVQRRVEPKVTVYPRTNLLVCSVNGFYPGSI EVRWFNSVVSTGLIQNGDWTFQTLVMLETVPRSGEVYTCQ VEHPSVTSPLTVEWR C:  VHFFKNIVTPRTPG D:  EHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVW RLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPIT NVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLR NGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDC RVEHWGLDEPLLKHWEFD E:  DTRPRFLQQDKYECHFFNGTERVRFLHRDIYNQEEDLRFD SDVGEYRAVTELGRPDAEYWNSQKDFLEDRRAAVDTYCRH NYGVGESFTVQRRVEPKVTVYPRTNLLVCSVNGFYPGSIE VRWFRNSQEVVSTGLIQNGDWTFQTLVMLEPRSGEVYTCQ VEHPSVTSPLTVEWR F:  VHFFKNIVTPRTPGG G:  EHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVW RLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPIT NVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLR NGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDC RVEHWGLDEPLLKHWEFD H:  GDTRPRFLQQDKYECHFFNGTERVRFLHRDIYNQEEDLRF DSDVGEYRAVTELGRPDAEYWNSQKDFLEDRRAAVDTYCR HNYGVGESFTVQRRVEPKVTVYPANLLVCSVNGFYPGSIE VRWFVVSTGLIQNGDWTFQTLVMLESGEVYTCQVEHPSVT SPLTVEWR I:  HFFKNIVTPRTPG J:  EHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVW RLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPIT NVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLR NGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDC RVEHWGLDEPLLKHWEFD K:  GDTRPRFLQQDKYECHFFNGTERVRFLHRDIYNQEEDLRF DSDVGEYRAVTELGRPDAEYWNSQKDFLEDRRAAVDTYCR HNYGVGESFTVQRRVEPKVTVYPNLLVCSVNGFYPGSIEV RWFRNSQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRSGE VYTCQVEHPSVTSPLTVEWR L:  VHFFKNIVTPRTPG M:  DSVTQMEGPVTLSEEAFLTINCTYTATGYPSLFWYVQYPG EGLQLLLKATKADDKGSNKGFEATYRKETTSFHLEKGSVQ VSDSAVYFCALSGGDSSYKLIFGSGTRLLVRPDNPDPVYS VCLFTDFDSQTNDVYITDKTVLDMRSMDFKSNSAVAWSNS DFACANAFNNSIIPEDTF P:  GGGGGVTQTPRYLIKTRGQQVTLSCSPISGHRSVSWYQQT PGQGLQFLFEYFNETQRNKGNFPGRFSGRQFSNSRSEMNV STLELGDSALYLCASSLADRVNTEAFFGQGTRLTVVEDLK NVFPPEVAVFEPSEAEISHTQATLVCLATGFYPDHVELSW WVNGKEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSAT FWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEA WG Q:  GDSVTQMEGPVTLSEEAFLTINCTYTATGYPSLFWYVQYP GEGLQLLLKATKADDKGSNKGFEATYRKETTSFHLEKGSV QVSDSAVYFCALSGGDSSYKLIFGSGTRLLVRPNPDPVYL RDSSVCLFTDFDSQTNVSQSDVYITDKTVLDMRSMDFKSN SAVAWSNKSDFACANAFNNSIIPEDTF R:  GGGGVTQTPRYLIKTRGQQVTLSCSPISGHRSVSWYQQTP GQGLQFLFEYFNETQRNKGNFPGRFSGRQFSNSRSEMNVS TLELGDSALYLCASSLADRVNTEAFFGQGTRLTVVEDLKN VFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSW WVNGKEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSAT FWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSA S:  DSVTQMEGPVTLSEEAFLTINCTYTATGYPSLFWYVQYPG EGLQLLLKATKADDKGSNKGFEATYRKETTSFHLEKGSVQ VSDSAVYFCALSGGDSSYKLIFGSGTRLLVRPQNPDPVYL RDSLFTFDSQTNSKDDVYITDKTVLDMRSMDFKSNSAVAN KSDFANAFNNSPEDTF T:  GGGGGVTQTPRYLIKTRGQQVTLSCSPISGHRSVSWYQQT PGQGLQFLFEYFNETQRNKGNFPGRFSGRQFSNSRSEMNV STLELGDSALYLCASSLADRVNTEAFFGQGTRLTVVEDLK NVFPPEVVFEISHTQATLVCLATGFYPDHVELSWWVNVHS GVSTDPQPLKEQPALNDSRYSLSSRATWQNPRHFRCQVQF YGLSENDEWTQDRAKPVTQIVSWGAD U:  GDSVTQMEGPVTLSEEAFLTINCTYTATGYPSLFWYVQYP GEGLQLLLKATKADDKGSNKGFEATYRKETTSFHLEKGSV QVSDSAVYFCALSGGDSSYKLIFGSGTRLLVRPDIQNPDP VYQLRDSKKSVCLFTDFDSQTNVSQSDVYITDKTVLDMRS MDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFP V:  GGGGVTQTPRYLIKTRGQQVTLSCSPISGHRSVSWYQQTP GQGLQFLFEYFNETQRNKGNFPGRFSGRQFSNSRSEMNVS TLELGDSALYLCASSLADRVNTEAFFGQGTRLTVVEDLKN VFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSW WVNGKEVHSGVSTDPQPLKEQPALNDSRYSLSSRLRVSAT FWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEA WG Description (1)  HLA class II histocompatibility antigen, DR alpha chain, major histocompatibility complex, class II, DR beta 5, Myelin basic protein Functional site 1) chain A residue 55 type SITE sequence E description Pathogen-derived peptide antigen => ECO:0000269|PubMed:23260142, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI5 2) chain D residue 55 type SITE sequence E description Pathogen-derived peptide antigen => ECO:0000269|PubMed:23260142, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI5 3) chain G residue 55 type SITE sequence E description Pathogen-derived peptide antigen => ECO:0000269|PubMed:23260142, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI5 4) chain J residue 55 type SITE sequence E description Pathogen-derived peptide antigen => ECO:0000269|PubMed:23260142, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI5 5) chain A residue 62 type SITE sequence N description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI6 6) chain D residue 62 type SITE sequence N description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI6 7) chain G residue 62 type SITE sequence N description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI6 8) chain J residue 62 type SITE sequence N description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI6 9) chain A residue 69 type SITE sequence N description Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI7 10) chain D residue 69 type SITE sequence N description Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI7 11) chain G residue 69 type SITE sequence N description Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI7 12) chain J residue 69 type SITE sequence N description Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI7 13) chain A residue 76 type SITE sequence R description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI8 14) chain D residue 76 type SITE sequence R description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI8 15) chain G residue 76 type SITE sequence R description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI8 16) chain J residue 76 type SITE sequence R description Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX source Swiss-Prot : SWS_FT_FI8 17) chain A residue 78 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 source Swiss-Prot : SWS_FT_FI9 18) chain A residue 118 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 source Swiss-Prot : SWS_FT_FI9 19) chain D residue 78 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 source Swiss-Prot : SWS_FT_FI9 20) chain D residue 118 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 source Swiss-Prot : SWS_FT_FI9 21) chain G residue 78 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 source Swiss-Prot : SWS_FT_FI9 22) chain G residue 118 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 source Swiss-Prot : SWS_FT_FI9 23) chain J residue 78 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 source Swiss-Prot : SWS_FT_FI9 24) chain J residue 118 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400 source Swiss-Prot : SWS_FT_FI9 25) chain P residue 187 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 source Swiss-Prot : SWS_FT_FI1 26) chain R residue 187 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 source Swiss-Prot : SWS_FT_FI1 27) chain T residue 187 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 source Swiss-Prot : SWS_FT_FI1 28) chain V residue 187 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 source Swiss-Prot : SWS_FT_FI1 29) chain S residue 149 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 source Swiss-Prot : SWS_FT_FI1 30) chain S residue 183 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 source Swiss-Prot : SWS_FT_FI1 31) chain U residue 149 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 source Swiss-Prot : SWS_FT_FI1 32) chain U residue 183 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 source Swiss-Prot : SWS_FT_FI1 33) chain M residue 192 type CARBOHYD sequence A description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 source Swiss-Prot : SWS_FT_FI2 34) chain Q residue 194 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 source Swiss-Prot : SWS_FT_FI2 35) chain S residue 194 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 source Swiss-Prot : SWS_FT_FI2 36) chain U residue 194 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 source Swiss-Prot : SWS_FT_FI2 37) chain G residue 49 type CARBOHYD sequence G description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 source Swiss-Prot : SWS_FT_FI2 38) chain G residue 52 type CARBOHYD sequence A description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 source Swiss-Prot : SWS_FT_FI2 39) chain J residue 49 type CARBOHYD sequence G description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 source Swiss-Prot : SWS_FT_FI2 40) chain J residue 52 type CARBOHYD sequence A description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 source Swiss-Prot : SWS_FT_FI2 41) chain A residue 161-167 type prosite sequence YDCRVEH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCRVEH source prosite : PS00290 42) chain B residue 171-177 type prosite sequence YTCQVEH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCRVEH source prosite : PS00290 43) chain C residue 11 type MOD_RES sequence R description Citrulline => ECO:0000269|PubMed:23828821 source Swiss-Prot : SWS_FT_FI3 44) chain F residue 11 type MOD_RES sequence R description Citrulline => ECO:0000269|PubMed:23828821 source Swiss-Prot : SWS_FT_FI3 45) chain I residue 11 type MOD_RES sequence R description Citrulline => ECO:0000269|PubMed:23828821 source Swiss-Prot : SWS_FT_FI3 46) chain L residue 11 type MOD_RES sequence R description Citrulline => ECO:0000269|PubMed:23828821 source Swiss-Prot : SWS_FT_FI3 47) chain C residue 12 type MOD_RES sequence T description Phosphothreonine => ECO:0000250|UniProtKB:P02687 source Swiss-Prot : SWS_FT_FI4 48) chain F residue 12 type MOD_RES sequence T description Phosphothreonine => ECO:0000250|UniProtKB:P02687 source Swiss-Prot : SWS_FT_FI4 49) chain I residue 12 type MOD_RES sequence T description Phosphothreonine => ECO:0000250|UniProtKB:P02687 source Swiss-Prot : SWS_FT_FI4 50) chain L residue 12 type MOD_RES sequence T description Phosphothreonine => ECO:0000250|UniProtKB:P02687 source Swiss-Prot : SWS_FT_FI4

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