|
|
eF-site ID
|
1zgl-A |
|
PDB Code
|
1zgl |
|
Chain
|
A |
|
click to enlarge
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|
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Title
|
Crystal structure of 3A6 TCR bound to MBP/HLA-DR2a |
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Classification
|
IMMUNE SYSTEM |
|
Compound
|
HLA class II histocompatibility antigen, DR alpha chain |
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Source
|
(TCB_HUMAN) |
|
|
Sequence
|
A: |
EHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVW
RLEEFGRFASFEAQGALANIAVDKANLEIMTKRSNYTPIT
NVPPEVTVLTNSPVELREPNVLICFIDKFTPPVVNVTWLR
NGKPVTTGVSETVFLPREDHLFRKFHYLPFLPSTEDVYDC
RVEHWGLDEPLLKHWEFD
|
|
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Description
|
(1) |
HLA class II histocompatibility antigen, DR alpha chain, major histocompatibility complex, class II, DR beta 5, Myelin basic protein
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
161-167 |
| type |
prosite |
| sequence |
YDCRVEH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCRVEH
|
| source |
prosite : PS00290
|
|
|
2)
|
chain |
A |
| residue |
55 |
| type |
SITE |
| sequence |
E
|
| description |
Pathogen-derived peptide antigen => ECO:0000269|PubMed:23260142, ECO:0007744|PDB:4GBX
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
3)
|
chain |
A |
| residue |
62 |
| type |
SITE |
| sequence |
N
|
| description |
Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
|
4)
|
chain |
A |
| residue |
69 |
| type |
SITE |
| sequence |
N
|
| description |
Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX
|
| source |
Swiss-Prot : SWS_FT_FI7
|
|
|
5)
|
chain |
A |
| residue |
76 |
| type |
SITE |
| sequence |
R
|
| description |
Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX
|
| source |
Swiss-Prot : SWS_FT_FI8
|
|
|
6)
|
chain |
A |
| residue |
78 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400
|
| source |
Swiss-Prot : SWS_FT_FI9
|
|
|
7)
|
chain |
A |
| residue |
118 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400
|
| source |
Swiss-Prot : SWS_FT_FI9
|
|
|
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