eF-site ID 1zcm-A
PDB Code 1zcm
Chain A

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Title Human calpain protease core inhibited by ZLLYCH2F
Classification HYDROLASE
Compound Calpain 1, large [catalytic] subunit
Source Homo sapiens (Human) (CAN1_HUMAN)
Sequence A:  NAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKD
LGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGAL
GDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQ
LWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLE
KAYAKVNGSYEALSGGSTSEAFEDFTGGVTEWYELRKAPS
DLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVKGH
AYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSS
EWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICN
L
Description


Functional site

1) chain A
residue 302
type
sequence E
description BINDING SITE FOR RESIDUE CA A 1001
source : AC1

2) chain A
residue 309
type
sequence D
description BINDING SITE FOR RESIDUE CA A 1001
source : AC1

3) chain A
residue 329
type
sequence M
description BINDING SITE FOR RESIDUE CA A 1001
source : AC1

4) chain A
residue 331
type
sequence D
description BINDING SITE FOR RESIDUE CA A 1001
source : AC1

5) chain A
residue 333
type
sequence E
description BINDING SITE FOR RESIDUE CA A 1001
source : AC1

6) chain A
residue 99
type
sequence V
description BINDING SITE FOR RESIDUE CA A 1002
source : AC2

7) chain A
residue 101
type
sequence G
description BINDING SITE FOR RESIDUE CA A 1002
source : AC2

8) chain A
residue 106
type
sequence D
description BINDING SITE FOR RESIDUE CA A 1002
source : AC2

9) chain A
residue 185
type
sequence E
description BINDING SITE FOR RESIDUE CA A 1002
source : AC2

10) chain A
residue 109
type
sequence Q
description BINDING SITE FOR RESIDUE C1N A 1115
source : AC3

11) chain A
residue 113
type
sequence G
description BINDING SITE FOR RESIDUE C1N A 1115
source : AC3

12) chain A
residue 114
type
sequence D
description BINDING SITE FOR RESIDUE C1N A 1115
source : AC3

13) chain A
residue 115
type
sequence C
description BINDING SITE FOR RESIDUE C1N A 1115
source : AC3

14) chain A
residue 116
type
sequence W
description BINDING SITE FOR RESIDUE C1N A 1115
source : AC3

15) chain A
residue 206
type
sequence S
description BINDING SITE FOR RESIDUE C1N A 1115
source : AC3

16) chain A
residue 207
type
sequence G
description BINDING SITE FOR RESIDUE C1N A 1115
source : AC3

17) chain A
residue 208
type
sequence G
description BINDING SITE FOR RESIDUE C1N A 1115
source : AC3

18) chain A
residue 210
type
sequence T
description BINDING SITE FOR RESIDUE C1N A 1115
source : AC3

19) chain A
residue 261
type
sequence E
description BINDING SITE FOR RESIDUE C1N A 1115
source : AC3

20) chain A
residue 271
type
sequence G
description BINDING SITE FOR RESIDUE C1N A 1115
source : AC3

21) chain A
residue 272
type
sequence H
description BINDING SITE FOR RESIDUE C1N A 1115
source : AC3

22) chain A
residue 284
type
sequence Y
description BINDING SITE FOR RESIDUE C1N A 1115
source : AC3

23) chain A
residue 285
type
sequence R
description BINDING SITE FOR RESIDUE C1N A 1115
source : AC3

24) chain A
residue 287
type
sequence Q
description BINDING SITE FOR RESIDUE C1N A 1115
source : AC3

25) chain A
residue 288
type
sequence V
description BINDING SITE FOR RESIDUE C1N A 1115
source : AC3

26) chain A
residue 109-120
type prosite
sequence QGALGDCWLLAA
description THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGaLGDCWLlAA
source prosite : PS00139

27) chain A
residue 115
type ACT_SITE
sequence C
description ACT_SITE => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

28) chain A
residue 272
type ACT_SITE
sequence H
description ACT_SITE => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

29) chain A
residue 296
type ACT_SITE
sequence N
description ACT_SITE => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

30) chain A
residue 109
type BINDING
sequence Q
description BINDING => ECO:0000305
source Swiss-Prot : SWS_FT_FI2

31) chain A
residue 114
type BINDING
sequence D
description BINDING => ECO:0000305
source Swiss-Prot : SWS_FT_FI2

32) chain A
residue 316
type BINDING
sequence N
description BINDING => ECO:0000305
source Swiss-Prot : SWS_FT_FI2

33) chain A
residue 318
type BINDING
sequence D
description BINDING => ECO:0000305
source Swiss-Prot : SWS_FT_FI2

34) chain A
residue 323
type BINDING
sequence D
description BINDING => ECO:0000305
source Swiss-Prot : SWS_FT_FI2


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