eF-site ID 1zcm-A PDB Code 1zcm Chain A click to enlarge Title Human calpain protease core inhibited by ZLLYCH2F Classification HYDROLASE Compound Calpain 1, large [catalytic] subunit Source Homo sapiens (Human) (CAN1_HUMAN) Sequence A:  NAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKD LGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGAL GDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQ LWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLE KAYAKVNGSYEALSGGSTSEAFEDFTGGVTEWYELRKAPS DLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVKGH AYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSS EWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICN L Description Functional site 1) chain A residue 302 type sequence E description BINDING SITE FOR RESIDUE CA A 1001 source : AC1 2) chain A residue 309 type sequence D description BINDING SITE FOR RESIDUE CA A 1001 source : AC1 3) chain A residue 329 type sequence M description BINDING SITE FOR RESIDUE CA A 1001 source : AC1 4) chain A residue 331 type sequence D description BINDING SITE FOR RESIDUE CA A 1001 source : AC1 5) chain A residue 333 type sequence E description BINDING SITE FOR RESIDUE CA A 1001 source : AC1 6) chain A residue 99 type sequence V description BINDING SITE FOR RESIDUE CA A 1002 source : AC2 7) chain A residue 101 type sequence G description BINDING SITE FOR RESIDUE CA A 1002 source : AC2 8) chain A residue 106 type sequence D description BINDING SITE FOR RESIDUE CA A 1002 source : AC2 9) chain A residue 185 type sequence E description BINDING SITE FOR RESIDUE CA A 1002 source : AC2 10) chain A residue 109 type sequence Q description BINDING SITE FOR RESIDUE C1N A 1115 source : AC3 11) chain A residue 113 type sequence G description BINDING SITE FOR RESIDUE C1N A 1115 source : AC3 12) chain A residue 114 type sequence D description BINDING SITE FOR RESIDUE C1N A 1115 source : AC3 13) chain A residue 115 type sequence C description BINDING SITE FOR RESIDUE C1N A 1115 source : AC3 14) chain A residue 116 type sequence W description BINDING SITE FOR RESIDUE C1N A 1115 source : AC3 15) chain A residue 206 type sequence S description BINDING SITE FOR RESIDUE C1N A 1115 source : AC3 16) chain A residue 207 type sequence G description BINDING SITE FOR RESIDUE C1N A 1115 source : AC3 17) chain A residue 208 type sequence G description BINDING SITE FOR RESIDUE C1N A 1115 source : AC3 18) chain A residue 210 type sequence T description BINDING SITE FOR RESIDUE C1N A 1115 source : AC3 19) chain A residue 261 type sequence E description BINDING SITE FOR RESIDUE C1N A 1115 source : AC3 20) chain A residue 271 type sequence G description BINDING SITE FOR RESIDUE C1N A 1115 source : AC3 21) chain A residue 272 type sequence H description BINDING SITE FOR RESIDUE C1N A 1115 source : AC3 22) chain A residue 284 type sequence Y description BINDING SITE FOR RESIDUE C1N A 1115 source : AC3 23) chain A residue 285 type sequence R description BINDING SITE FOR RESIDUE C1N A 1115 source : AC3 24) chain A residue 287 type sequence Q description BINDING SITE FOR RESIDUE C1N A 1115 source : AC3 25) chain A residue 288 type sequence V description BINDING SITE FOR RESIDUE C1N A 1115 source : AC3 26) chain A residue 109-120 type prosite sequence QGALGDCWLLAA description THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGaLGDCWLlAA source prosite : PS00139 27) chain A residue 115 type ACT_SITE sequence C description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 28) chain A residue 272 type ACT_SITE sequence H description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 29) chain A residue 296 type ACT_SITE sequence N description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 30) chain A residue 109 type BINDING sequence Q description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI2 31) chain A residue 114 type BINDING sequence D description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI2 32) chain A residue 316 type BINDING sequence N description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI2 33) chain A residue 318 type BINDING sequence D description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI2 34) chain A residue 323 type BINDING sequence D description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI2

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