eF-site ID 1zcd-B PDB Code 1zcd Chain B click to enlarge Title Crystal structure of the Na+/H+ antiporter NhaA Classification MEMBRANE PROTEIN Compound Na(+)/H(+) antiporter 1 Source null (NHAA_ECOLI) Sequence B:  SSDASGGIILIIAAILAMIMANSGATSGWYHDFLETPVQL RVGSLEINKNMLLWINDALMAVFFLLVGLEVKRELMQGSL ASLRQAAFPVIAAIGGMIVPALLYLAFNYADPITREGWAI PAATDIAFALGVLALLGSRVPLALKIFLMALAIIDDLGAI IIIALFYTNDLSMASLGVAAVAIAVLAVLNLCGARRTGVY ILVGVVLWTAVLKSGVHATLAGVIVGFFIPLKEKHGRSPA KRLEHVLHPWVAYLILPLFAFANAGVSLQGVTLDGLTSIL PLGIIAGLLIGKPLGISLFCWLALRLKLAHLPEGTTYQQI MVVGILCGIGFTMSIFIASLAFGSVDPELINWAKLGILVG SISSAVIGYSWLRVRL Description Functional site 1) chain B residue 201-204 type TOPO_DOM sequence GARR description Cytoplasmic => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 source Swiss-Prot : SWS_FT_FI1 2) chain B residue 237-253 type TOPO_DOM sequence IPLKEKHGRSPAKRLEH description Cytoplasmic => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 source Swiss-Prot : SWS_FT_FI1 3) chain B residue 311-339 type TOPO_DOM sequence ALRLKLAHLPEGTTYQQIMVVGILCGIGF description Cytoplasmic => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 source Swiss-Prot : SWS_FT_FI1 4) chain B residue 81-96 type TOPO_DOM sequence RELMQGSLASLRQAAF description Cytoplasmic => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 source Swiss-Prot : SWS_FT_FI1 5) chain B residue 131-154 type TOPO_DOM sequence ATDIAFALGVLALLGSRVPLALKI description Cytoplasmic => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 source Swiss-Prot : SWS_FT_FI1 6) chain B residue 163 type SITE sequence D description Essential for cation binding and translocation => ECO:0000305|PubMed:15988517, ECO:0000305|PubMed:19274728, ECO:0000305|PubMed:22915592, ECO:0000305|PubMed:25422503, ECO:0000305|PubMed:27021484, ECO:0000305|PubMed:27708266, ECO:0000305|PubMed:30409911, ECO:0000305|PubMed:7737413 source Swiss-Prot : SWS_FT_FI17 7) chain B residue 164 type SITE sequence D description Essential for cation binding and translocation => ECO:0000305|PubMed:15988517, ECO:0000305|PubMed:19274728, ECO:0000305|PubMed:22915592, ECO:0000305|PubMed:25422503, ECO:0000305|PubMed:27021484, ECO:0000305|PubMed:27708266, ECO:0000305|PubMed:7737413 source Swiss-Prot : SWS_FT_FI18 8) chain B residue 241 type SITE sequence E description Important for pH response => ECO:0000305|PubMed:10455127 source Swiss-Prot : SWS_FT_FI19 9) chain B residue 254 type SITE sequence V description Important for pH response => ECO:0000305|PubMed:10455127 source Swiss-Prot : SWS_FT_FI19 10) chain B residue 252 type SITE sequence E description Important for pH response => ECO:0000305|PubMed:14604993 source Swiss-Prot : SWS_FT_FI20 11) chain B residue 300 type SITE sequence K description Important for stability and activity => ECO:0000305|PubMed:15988517, ECO:0000305|PubMed:22915592, ECO:0000305|PubMed:25422503, ECO:0000305|PubMed:27708266, ECO:0000305|PubMed:28330875, ECO:0000305|PubMed:30409911 source Swiss-Prot : SWS_FT_FI21 12) chain B residue 133 type SITE sequence D description Important for stability, cation binding and translocation => ECO:0000305|PubMed:15988517, ECO:0000305|PubMed:22915592, ECO:0000305|PubMed:27021484, ECO:0000305|PubMed:29410365, ECO:0000305|PubMed:7737413 source Swiss-Prot : SWS_FT_FI16 13) chain B residue 223 type TOPO_DOM sequence G description Periplasmic => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 source Swiss-Prot : SWS_FT_FI3 14) chain B residue 273-286 type TOPO_DOM sequence GVSLQGVTLDGLTS description Periplasmic => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 source Swiss-Prot : SWS_FT_FI3 15) chain B residue 351-357 type TOPO_DOM sequence GSVDPEL description Periplasmic => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 source Swiss-Prot : SWS_FT_FI3 16) chain B residue 32-58 type TOPO_DOM sequence GATSGWYHDFLETPVQLRVGSLEINKN description Periplasmic => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 source Swiss-Prot : SWS_FT_FI3 17) chain B residue 117-122 type TOPO_DOM sequence YADPIT description Periplasmic => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 source Swiss-Prot : SWS_FT_FI3 18) chain B residue 177-180 type TOPO_DOM sequence NDLS description Periplasmic => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 source Swiss-Prot : SWS_FT_FI3 19) chain B residue 12-31 type TRANSMEM sequence ASGGIILIIAAILAMIMANS description Helical; Name=1 => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 source Swiss-Prot : SWS_FT_FI2 20) chain B residue 59-80 type TRANSMEM sequence MLLWINDALMAVFFLLVGLEVK description Helical; Name=2 => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 source Swiss-Prot : SWS_FT_FI4 21) chain B residue 97-116 type TRANSMEM sequence PVIAAIGGMIVPALLYLAFN description Helical; Name=3 => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 source Swiss-Prot : SWS_FT_FI5 22) chain B residue 123-130 type TRANSMEM sequence REGWAIPA description Helical; Name=4 => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 source Swiss-Prot : SWS_FT_FI6 23) chain B residue 155-176 type TRANSMEM sequence FLMALAIIDDLGAIIIIALFYT description Helical; Name=5 => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 source Swiss-Prot : SWS_FT_FI7 24) chain B residue 181-200 type TRANSMEM sequence MASLGVAAVAIAVLAVLNLC description Helical; Name=6 => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 source Swiss-Prot : SWS_FT_FI8 25) chain B residue 205-222 type TRANSMEM sequence TGVYILVGVVLWTAVLKS description Helical; Name=7 => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 source Swiss-Prot : SWS_FT_FI9 26) chain B residue 224-236 type TRANSMEM sequence VHATLAGVIVGFF description Helical; Name=8 => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 source Swiss-Prot : SWS_FT_FI10 27) chain B residue 254-272 type TRANSMEM sequence VLHPWVAYLILPLFAFANA description Helical; Name=9 => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 source Swiss-Prot : SWS_FT_FI11 28) chain B residue 287-310 type TRANSMEM sequence ILPLGIIAGLLIGKPLGISLFCWL description Helical; Name=10 => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 source Swiss-Prot : SWS_FT_FI12 29) chain B residue 340-350 type TRANSMEM sequence TMSIFIASLAF description Helical; Name=11 => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 source Swiss-Prot : SWS_FT_FI13 30) chain B residue 358-380 type TRANSMEM sequence INWAKLGILVGSISSAVIGYSWL description Helical; Name=12 => ECO:0000269|PubMed:25422503, ECO:0007744|PDB:4ATV, ECO:0007744|PDB:4AU5 source Swiss-Prot : SWS_FT_FI14

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