eF-site ID 1zbg-AB PDB Code 1zbg Chain A, B click to enlarge Title Crystal structure of a complex of mutant hiv-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2 Classification HYDROLASE/HYDROLASE INHIBITOR Compound PROTEASE RETROPEPSIN Source Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) (POL_HV1BR) Sequence A:  PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPG RWKPKMIGGIGGFIKVRQYDQILIEIXGHKVIGTVLVGPT PTNVIGRNLLTQIGCTLNF B:  PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPG RWKPKMIGGIGGFIKVRQYDQILIEIXGHKVIGTVLVGPT PTNVIGRNLLTQIGCTLNF Description Functional site 1) chain A residue 8 type sequence R description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 2) chain A residue 23 type sequence L description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 3) chain A residue 25 type sequence D description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 4) chain A residue 27 type sequence G description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 5) chain A residue 30 type sequence D description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 6) chain A residue 48 type sequence G description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 7) chain A residue 82 type sequence T description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 8) chain B residue 108 type sequence R description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 9) chain B residue 125 type sequence D description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 10) chain B residue 127 type sequence G description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 11) chain B residue 128 type sequence A description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 12) chain B residue 129 type sequence D description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 13) chain B residue 130 type sequence D description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 14) chain B residue 147 type sequence I description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 15) chain B residue 148 type sequence G description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 16) chain B residue 149 type sequence G description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 17) chain B residue 181 type sequence P description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 18) chain B residue 182 type sequence T description BINDING SITE FOR RESIDUE 0ZS B 201 source : AC1 19) chain A residue 73 type sequence G description BINDING SITE FOR RESIDUE CL A 211 source : AC2 20) chain A residue 74 type sequence T description BINDING SITE FOR RESIDUE CL A 211 source : AC2 21) chain A residue 88 type sequence N description BINDING SITE FOR RESIDUE CL A 211 source : AC2 22) chain A residue 41 type sequence R description BINDING SITE FOR RESIDUE CL B 212 source : AC3 23) chain B residue 174 type sequence T description BINDING SITE FOR RESIDUE CL B 212 source : AC3 24) chain B residue 188 type sequence N description BINDING SITE FOR RESIDUE CL B 212 source : AC3 25) chain A residue 6 type sequence W description BINDING SITE FOR RESIDUE CL A 213 source : AC4 26) chain A residue 78 type sequence G description BINDING SITE FOR RESIDUE NA B 214 source : AC5 27) chain A residue 80 type sequence T description BINDING SITE FOR RESIDUE NA B 214 source : AC5 28) chain B residue 107 type sequence Q description BINDING SITE FOR RESIDUE NA B 214 source : AC5 29) chain A residue 64 type SITE sequence I description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 30) chain B residue 164 type SITE sequence I description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 31) chain A residue 64 type MOD_RES sequence I description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 32) chain B residue 164 type MOD_RES sequence I description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 33) chain A residue 22-33 type prosite sequence ALLDTGADDTVL description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL source prosite : PS00141

Display surface Download Links