eF-site ID 1zbg-A
PDB Code 1zbg
Chain A

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Title Crystal structure of a complex of mutant hiv-1 protease (A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2
Classification HYDROLASE/HYDROLASE INHIBITOR
Compound PROTEASE RETROPEPSIN
Source Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) (POL_HV1BR)
Sequence A:  PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPG
RWKPKMIGGIGGFIKVRQYDQILIEIXGHKVIGTVLVGPT
PTNVIGRNLLTQIGCTLNF
Description


Functional site

1) chain A
residue 8
type
sequence R
description BINDING SITE FOR RESIDUE 0ZS B 201
source : AC1

2) chain A
residue 23
type
sequence L
description BINDING SITE FOR RESIDUE 0ZS B 201
source : AC1

3) chain A
residue 25
type
sequence D
description BINDING SITE FOR RESIDUE 0ZS B 201
source : AC1

4) chain A
residue 27
type
sequence G
description BINDING SITE FOR RESIDUE 0ZS B 201
source : AC1

5) chain A
residue 30
type
sequence D
description BINDING SITE FOR RESIDUE 0ZS B 201
source : AC1

6) chain A
residue 48
type
sequence G
description BINDING SITE FOR RESIDUE 0ZS B 201
source : AC1

7) chain A
residue 82
type
sequence T
description BINDING SITE FOR RESIDUE 0ZS B 201
source : AC1

8) chain A
residue 73
type
sequence G
description BINDING SITE FOR RESIDUE CL A 211
source : AC2

9) chain A
residue 74
type
sequence T
description BINDING SITE FOR RESIDUE CL A 211
source : AC2

10) chain A
residue 88
type
sequence N
description BINDING SITE FOR RESIDUE CL A 211
source : AC2

11) chain A
residue 41
type
sequence R
description BINDING SITE FOR RESIDUE CL B 212
source : AC3

12) chain A
residue 6
type
sequence W
description BINDING SITE FOR RESIDUE CL A 213
source : AC4

13) chain A
residue 78
type
sequence G
description BINDING SITE FOR RESIDUE NA B 214
source : AC5

14) chain A
residue 80
type
sequence T
description BINDING SITE FOR RESIDUE NA B 214
source : AC5

15) chain A
residue 22-33
type prosite
sequence ALLDTGADDTVL
description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL
source prosite : PS00141

16) chain A
residue 64
type SITE
sequence I
description Cleavage; by viral protease => ECO:0000250
source Swiss-Prot : SWS_FT_FI1

17) chain A
residue 64
type MOD_RES
sequence I
description Phosphotyrosine; by host => ECO:0000250
source Swiss-Prot : SWS_FT_FI2


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