eF-site ID 1z8c-A PDB Code 1z8c Chain A click to enlarge Title Crystal structure of the complex of mutant HIV-1 protease (l63P, A71V, V82T, I84V) with a hydroxyethylamine peptidomimetic inhibitor BOC-PHE-PSI[R-CH(OH)CH2NH]-PHE-GLU-PHE-NH2 Classification HYDROLASE/HYDROLASE INHIBITOR Compound PROTEASE RETROPEPSIN Source Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) (POL_HV1BR) Sequence A:  PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPG RWKPKMIGGIGGFIKVRQYDQIPIEIXGHKVIGTVLVGPT PTNVIGRNLLTQIGCTLNF Description Functional site 1) chain A residue 25 type sequence D description BINDING SITE FOR RESIDUE 0ZS A 201 source : AC1 2) chain A residue 27 type sequence G description BINDING SITE FOR RESIDUE 0ZS A 201 source : AC1 3) chain A residue 28 type sequence A description BINDING SITE FOR RESIDUE 0ZS A 201 source : AC1 4) chain A residue 29 type sequence D description BINDING SITE FOR RESIDUE 0ZS A 201 source : AC1 5) chain A residue 30 type sequence D description BINDING SITE FOR RESIDUE 0ZS A 201 source : AC1 6) chain A residue 47 type sequence I description BINDING SITE FOR RESIDUE 0ZS A 201 source : AC1 7) chain A residue 48 type sequence G description BINDING SITE FOR RESIDUE 0ZS A 201 source : AC1 8) chain A residue 49 type sequence G description BINDING SITE FOR RESIDUE 0ZS A 201 source : AC1 9) chain A residue 50 type sequence I description BINDING SITE FOR RESIDUE 0ZS A 201 source : AC1 10) chain A residue 81 type sequence P description BINDING SITE FOR RESIDUE 0ZS A 201 source : AC1 11) chain A residue 82 type sequence T description BINDING SITE FOR RESIDUE 0ZS A 201 source : AC1 12) chain A residue 42 type sequence W description BINDING SITE FOR RESIDUE SO4 A 501 source : AC2 13) chain A residue 55 type sequence K description BINDING SITE FOR RESIDUE SO4 A 501 source : AC2 14) chain A residue 57 type sequence R description BINDING SITE FOR RESIDUE SO4 A 501 source : AC2 15) chain A residue 22-33 type prosite sequence ALLDTGADDTVL description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL source prosite : PS00141 16) chain A residue 64 type SITE sequence I description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 64 type MOD_RES sequence I description Phosphotyrosine; by host => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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