eF-site ID 1z6t-ABCD PDB Code 1z6t Chain A, B, C, D click to enlarge Title Structure of the apoptotic protease-activating factor 1 bound to ADP Classification APOPTOSIS Compound Apoptotic protease activating factor 1 Source null (APAF_HUMAN) Sequence A:  MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEE EKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGY KDLAALLHDGIPVVGITSYVRTVLCEGGVPQRPVVFVTRK KLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRD HSLLEGCFPGGVHWVSVGKQDKSGLLMKLQNLCTRLDQDE SFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWV LKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEK GLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGAL LRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSI SVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEE VEDILQEFVNKSLLFCDRNGKSFRYYLHDLQVDFLTEKNC SQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYH MASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYR HILDEKDCAVSENFQEFLSLNGHLLGRQPFPNIVQLGLCE PETSEVYQQAKLQAKQ B:  MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEE EKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGY KDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGK SVLAAEAVRDHSLLEGCFPGGVHWVSVGKQDKSGLLMKLQ NLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVV PVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGS PLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVL CILWDMETEEVEDILQEFVNKSLLFCDRNGKSFRYYLHDL QVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPA HLIHEFVEYRHILDEKDCAVSENFQEFLSLNGHLLGRQPF PNIVQLGLCEPETSEVYQQAKLQAKQ C:  MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEE EKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGY KDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVP QRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGK SVLAAEAVRDHSLLEGCFPGGVHWVSVGKQDKSGLLMKLQ NLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLL ILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVV PVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGS PLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYD YEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVL CILWDMETEEVEDILQEFVNKSLLFCDRNGKSFRYYLHDL QVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDC MYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPA HLIHEFVEYRHILDEKDCAVSENFQEFLSLNGHLLGRQPF PNIVQLGLCEPETSEVYQQAKLQAKQ D:  MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEE EKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGY KDLAALLHDGIPVVGITSYVRTVLCEGGVPQRPVVFVTRK KLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRD HSLLEGCFPGGVHWVSVGKQDKSGLLMKLQNLCTRLDQDE SFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWV LKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEK GLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGAL LRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSI SVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEE VEDILQEFVNKSLLFCDRNGKSFRYYLHDLQVDFLTEKNC SQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYH MASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYR HILDEKDCAVSENFQEFLSLNGHLLGRQPFPNIVQLGLCE PETSEVYQQAKLQAKQ Description Functional site 1) chain A residue 125 type sequence V description BINDING SITE FOR RESIDUE ADP A 900 source : AC1 2) chain A residue 126 type sequence F description BINDING SITE FOR RESIDUE ADP A 900 source : AC1 3) chain A residue 127 type sequence V description BINDING SITE FOR RESIDUE ADP A 900 source : AC1 4) chain A residue 129 type sequence R description BINDING SITE FOR RESIDUE ADP A 900 source : AC1 5) chain A residue 157 type sequence G description BINDING SITE FOR RESIDUE ADP A 900 source : AC1 6) chain A residue 158 type sequence C description BINDING SITE FOR RESIDUE ADP A 900 source : AC1 7) chain A residue 159 type sequence G description BINDING SITE FOR RESIDUE ADP A 900 source : AC1 8) chain A residue 160 type sequence K description BINDING SITE FOR RESIDUE ADP A 900 source : AC1 9) chain A residue 161 type sequence S description BINDING SITE FOR RESIDUE ADP A 900 source : AC1 10) chain A residue 162 type sequence V description BINDING SITE FOR RESIDUE ADP A 900 source : AC1 11) chain A residue 321 type sequence P description BINDING SITE FOR RESIDUE ADP A 900 source : AC1 12) chain A residue 322 type sequence L description BINDING SITE FOR RESIDUE ADP A 900 source : AC1 13) chain A residue 425 type sequence F description BINDING SITE FOR RESIDUE ADP A 900 source : AC1 14) chain A residue 438 type sequence H description BINDING SITE FOR RESIDUE ADP A 900 source : AC1 15) chain B residue 125 type sequence V description BINDING SITE FOR RESIDUE ADP B 901 source : AC2 16) chain B residue 126 type sequence F description BINDING SITE FOR RESIDUE ADP B 901 source : AC2 17) chain B residue 127 type sequence V description BINDING SITE FOR RESIDUE ADP B 901 source : AC2 18) chain B residue 157 type sequence G description BINDING SITE FOR RESIDUE ADP B 901 source : AC2 19) chain B residue 158 type sequence C description BINDING SITE FOR RESIDUE ADP B 901 source : AC2 20) chain B residue 159 type sequence G description BINDING SITE FOR RESIDUE ADP B 901 source : AC2 21) chain B residue 160 type sequence K description BINDING SITE FOR RESIDUE ADP B 901 source : AC2 22) chain B residue 161 type sequence S description BINDING SITE FOR RESIDUE ADP B 901 source : AC2 23) chain B residue 162 type sequence V description BINDING SITE FOR RESIDUE ADP B 901 source : AC2 24) chain B residue 321 type sequence P description BINDING SITE FOR RESIDUE ADP B 901 source : AC2 25) chain B residue 322 type sequence L description BINDING SITE FOR RESIDUE ADP B 901 source : AC2 26) chain B residue 425 type sequence F description BINDING SITE FOR RESIDUE ADP B 901 source : AC2 27) chain B residue 438 type sequence H description BINDING SITE FOR RESIDUE ADP B 901 source : AC2 28) chain C residue 125 type sequence V description BINDING SITE FOR RESIDUE ADP C 902 source : AC3 29) chain C residue 126 type sequence F description BINDING SITE FOR RESIDUE ADP C 902 source : AC3 30) chain C residue 127 type sequence V description BINDING SITE FOR RESIDUE ADP C 902 source : AC3 31) chain C residue 157 type sequence G description BINDING SITE FOR RESIDUE ADP C 902 source : AC3 32) chain C residue 158 type sequence C description BINDING SITE FOR RESIDUE ADP C 902 source : AC3 33) chain C residue 159 type sequence G description BINDING SITE FOR RESIDUE ADP C 902 source : AC3 34) chain C residue 160 type sequence K description BINDING SITE FOR RESIDUE ADP C 902 source : AC3 35) chain C residue 161 type sequence S description BINDING SITE FOR RESIDUE ADP C 902 source : AC3 36) chain C residue 162 type sequence V description BINDING SITE FOR RESIDUE ADP C 902 source : AC3 37) chain C residue 321 type sequence P description BINDING SITE FOR RESIDUE ADP C 902 source : AC3 38) chain C residue 322 type sequence L description BINDING SITE FOR RESIDUE ADP C 902 source : AC3 39) chain C residue 425 type sequence F description BINDING SITE FOR RESIDUE ADP C 902 source : AC3 40) chain C residue 438 type sequence H description BINDING SITE FOR RESIDUE ADP C 902 source : AC3 41) chain D residue 125 type sequence V description BINDING SITE FOR RESIDUE ADP D 903 source : AC4 42) chain D residue 126 type sequence F description BINDING SITE FOR RESIDUE ADP D 903 source : AC4 43) chain D residue 127 type sequence V description BINDING SITE FOR RESIDUE ADP D 903 source : AC4 44) chain D residue 129 type sequence R description BINDING SITE FOR RESIDUE ADP D 903 source : AC4 45) chain D residue 157 type sequence G description BINDING SITE FOR RESIDUE ADP D 903 source : AC4 46) chain D residue 158 type sequence C description BINDING SITE FOR RESIDUE ADP D 903 source : AC4 47) chain D residue 159 type sequence G description BINDING SITE FOR RESIDUE ADP D 903 source : AC4 48) chain D residue 160 type sequence K description BINDING SITE FOR RESIDUE ADP D 903 source : AC4 49) chain D residue 161 type sequence S description BINDING SITE FOR RESIDUE ADP D 903 source : AC4 50) chain D residue 162 type sequence V description BINDING SITE FOR RESIDUE ADP D 903 source : AC4 51) chain D residue 321 type sequence P description BINDING SITE FOR RESIDUE ADP D 903 source : AC4 52) chain D residue 322 type sequence L description BINDING SITE FOR RESIDUE ADP D 903 source : AC4 53) chain D residue 425 type sequence F description BINDING SITE FOR RESIDUE ADP D 903 source : AC4 54) chain D residue 438 type sequence H description BINDING SITE FOR RESIDUE ADP D 903 source : AC4 55) chain A residue 154 type BINDING sequence G description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 56) chain B residue 154 type BINDING sequence G description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 57) chain C residue 154 type BINDING sequence G description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 58) chain D residue 154 type BINDING sequence G description BINDING => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 59) chain A residue 265 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 60) chain B residue 265 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 61) chain C residue 265 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 62) chain D residue 265 type BINDING sequence R description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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