eF-site ID 1yxu-D PDB Code 1yxu Chain D click to enlarge Title Crystal Structure of Kinase Pim1 in Complex with AMP Classification TRANSFERASE Compound Proto-oncogene serine/threonine-protein kinase Pim-1 Source Homo sapiens (Human) (PIM1_HUMAN) Sequence D:  PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKD RISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFER PDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGAL LKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILL YDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLA LRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLH Description Functional site 1) chain D residue 130 type sequence F description BINDING SITE FOR RESIDUE IMD D 800 source : AC4 2) chain D residue 133 type sequence I description BINDING SITE FOR RESIDUE IMD D 800 source : AC4 3) chain D residue 134 type sequence T description BINDING SITE FOR RESIDUE IMD D 800 source : AC4 4) chain D residue 170 type sequence D description BINDING SITE FOR RESIDUE IMD D 800 source : AC4 5) chain D residue 234 type sequence D description BINDING SITE FOR RESIDUE IMD D 800 source : AC4 6) chain D residue 238 type sequence G description BINDING SITE FOR RESIDUE IMD D 800 source : AC4 7) chain D residue 239 type sequence D description BINDING SITE FOR RESIDUE IMD D 800 source : AC4 8) chain D residue 49 type sequence F description BINDING SITE FOR RESIDUE AMP D 850 source : AC8 9) chain D residue 52 type sequence V description BINDING SITE FOR RESIDUE AMP D 850 source : AC8 10) chain D residue 65 type sequence A description BINDING SITE FOR RESIDUE AMP D 850 source : AC8 11) chain D residue 67 type sequence K description BINDING SITE FOR RESIDUE AMP D 850 source : AC8 12) chain D residue 89 type sequence E description BINDING SITE FOR RESIDUE AMP D 850 source : AC8 13) chain D residue 104 type sequence I description BINDING SITE FOR RESIDUE AMP D 850 source : AC8 14) chain D residue 120 type sequence L description BINDING SITE FOR RESIDUE AMP D 850 source : AC8 15) chain D residue 121 type sequence E description BINDING SITE FOR RESIDUE AMP D 850 source : AC8 16) chain D residue 122 type sequence R description BINDING SITE FOR RESIDUE AMP D 850 source : AC8 17) chain D residue 174 type sequence L description BINDING SITE FOR RESIDUE AMP D 850 source : AC8 18) chain D residue 185 type sequence I description BINDING SITE FOR RESIDUE AMP D 850 source : AC8 19) chain D residue 186 type sequence D description BINDING SITE FOR RESIDUE AMP D 850 source : AC8 20) chain D residue 167 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 21) chain D residue 44 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 22) chain D residue 98 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:15657054 source Swiss-Prot : SWS_FT_FI4 23) chain D residue 261 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:15657054 source Swiss-Prot : SWS_FT_FI4 24) chain D residue 67 type BINDING sequence K description BINDING => ECO:0000305|PubMed:15525646, ECO:0000305|PubMed:15657054, ECO:0000305|PubMed:15808862 source Swiss-Prot : SWS_FT_FI3 25) chain D residue 121 type BINDING sequence E description BINDING => ECO:0000305|PubMed:15525646, ECO:0000305|PubMed:15657054, ECO:0000305|PubMed:15808862 source Swiss-Prot : SWS_FT_FI3 26) chain D residue 128 type BINDING sequence D description BINDING => ECO:0000305|PubMed:15525646, ECO:0000305|PubMed:15657054, ECO:0000305|PubMed:15808862 source Swiss-Prot : SWS_FT_FI3

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