eF-site ID 1yxu-C PDB Code 1yxu Chain C click to enlarge Title Crystal Structure of Kinase Pim1 in Complex with AMP Classification TRANSFERASE Compound Proto-oncogene serine/threonine-protein kinase Pim-1 Source Homo sapiens (Human) (PIM1_HUMAN) Sequence C:  LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDR ISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERP DSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL KDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLY DMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLAL RPSDRPTFEEIQNHPWMQDVLLPQETAEIHLH Description Functional site 1) chain C residue 130 type sequence F description BINDING SITE FOR RESIDUE IMD C 700 source : AC3 2) chain C residue 134 type sequence T description BINDING SITE FOR RESIDUE IMD C 700 source : AC3 3) chain C residue 170 type sequence D description BINDING SITE FOR RESIDUE IMD C 700 source : AC3 4) chain C residue 234 type sequence D description BINDING SITE FOR RESIDUE IMD C 700 source : AC3 5) chain C residue 238 type sequence G description BINDING SITE FOR RESIDUE IMD C 700 source : AC3 6) chain C residue 44 type sequence L description BINDING SITE FOR RESIDUE AMP C 750 source : AC7 7) chain C residue 49 type sequence F description BINDING SITE FOR RESIDUE AMP C 750 source : AC7 8) chain C residue 65 type sequence A description BINDING SITE FOR RESIDUE AMP C 750 source : AC7 9) chain C residue 67 type sequence K description BINDING SITE FOR RESIDUE AMP C 750 source : AC7 10) chain C residue 104 type sequence I description BINDING SITE FOR RESIDUE AMP C 750 source : AC7 11) chain C residue 120 type sequence L description BINDING SITE FOR RESIDUE AMP C 750 source : AC7 12) chain C residue 122 type sequence R description BINDING SITE FOR RESIDUE AMP C 750 source : AC7 13) chain C residue 126 type sequence V description BINDING SITE FOR RESIDUE AMP C 750 source : AC7 14) chain C residue 171 type sequence E description BINDING SITE FOR RESIDUE AMP C 750 source : AC7 15) chain C residue 172 type sequence N description BINDING SITE FOR RESIDUE AMP C 750 source : AC7 16) chain C residue 174 type sequence L description BINDING SITE FOR RESIDUE AMP C 750 source : AC7 17) chain C residue 185 type sequence I description BINDING SITE FOR RESIDUE AMP C 750 source : AC7 18) chain C residue 186 type sequence D description BINDING SITE FOR RESIDUE AMP C 750 source : AC7 19) chain C residue 167 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 20) chain C residue 44 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 21) chain C residue 67 type BINDING sequence K description BINDING => ECO:0000305|PubMed:15525646, ECO:0000305|PubMed:15657054, ECO:0000305|PubMed:15808862 source Swiss-Prot : SWS_FT_FI3 22) chain C residue 121 type BINDING sequence E description BINDING => ECO:0000305|PubMed:15525646, ECO:0000305|PubMed:15657054, ECO:0000305|PubMed:15808862 source Swiss-Prot : SWS_FT_FI3 23) chain C residue 128 type BINDING sequence D description BINDING => ECO:0000305|PubMed:15525646, ECO:0000305|PubMed:15657054, ECO:0000305|PubMed:15808862 source Swiss-Prot : SWS_FT_FI3 24) chain C residue 98 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:15657054 source Swiss-Prot : SWS_FT_FI4 25) chain C residue 261 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:15657054 source Swiss-Prot : SWS_FT_FI4

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