eF-site ID 1yxu-B PDB Code 1yxu Chain B click to enlarge Title Crystal Structure of Kinase Pim1 in Complex with AMP Classification TRANSFERASE Compound Proto-oncogene serine/threonine-protein kinase Pim-1 Source Homo sapiens (Human) (PIM1_HUMAN) Sequence B:  PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKD RISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFER PDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGAL LKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILL YDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLA LRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLH Description Functional site 1) chain B residue 130 type sequence F description BINDING SITE FOR RESIDUE IMD B 600 source : AC2 2) chain B residue 133 type sequence I description BINDING SITE FOR RESIDUE IMD B 600 source : AC2 3) chain B residue 134 type sequence T description BINDING SITE FOR RESIDUE IMD B 600 source : AC2 4) chain B residue 170 type sequence D description BINDING SITE FOR RESIDUE IMD B 600 source : AC2 5) chain B residue 234 type sequence D description BINDING SITE FOR RESIDUE IMD B 600 source : AC2 6) chain B residue 238 type sequence G description BINDING SITE FOR RESIDUE IMD B 600 source : AC2 7) chain B residue 239 type sequence D description BINDING SITE FOR RESIDUE IMD B 600 source : AC2 8) chain B residue 44 type sequence L description BINDING SITE FOR RESIDUE AMP B 650 source : AC6 9) chain B residue 49 type sequence F description BINDING SITE FOR RESIDUE AMP B 650 source : AC6 10) chain B residue 52 type sequence V description BINDING SITE FOR RESIDUE AMP B 650 source : AC6 11) chain B residue 65 type sequence A description BINDING SITE FOR RESIDUE AMP B 650 source : AC6 12) chain B residue 67 type sequence K description BINDING SITE FOR RESIDUE AMP B 650 source : AC6 13) chain B residue 104 type sequence I description BINDING SITE FOR RESIDUE AMP B 650 source : AC6 14) chain B residue 120 type sequence L description BINDING SITE FOR RESIDUE AMP B 650 source : AC6 15) chain B residue 126 type sequence V description BINDING SITE FOR RESIDUE AMP B 650 source : AC6 16) chain B residue 171 type sequence E description BINDING SITE FOR RESIDUE AMP B 650 source : AC6 17) chain B residue 172 type sequence N description BINDING SITE FOR RESIDUE AMP B 650 source : AC6 18) chain B residue 185 type sequence I description BINDING SITE FOR RESIDUE AMP B 650 source : AC6 19) chain B residue 186 type sequence D description BINDING SITE FOR RESIDUE AMP B 650 source : AC6 20) chain B residue 167 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 21) chain B residue 44 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 22) chain B residue 67 type BINDING sequence K description BINDING => ECO:0000305|PubMed:15525646, ECO:0000305|PubMed:15657054, ECO:0000305|PubMed:15808862 source Swiss-Prot : SWS_FT_FI3 23) chain B residue 121 type BINDING sequence E description BINDING => ECO:0000305|PubMed:15525646, ECO:0000305|PubMed:15657054, ECO:0000305|PubMed:15808862 source Swiss-Prot : SWS_FT_FI3 24) chain B residue 128 type BINDING sequence D description BINDING => ECO:0000305|PubMed:15525646, ECO:0000305|PubMed:15657054, ECO:0000305|PubMed:15808862 source Swiss-Prot : SWS_FT_FI3 25) chain B residue 98 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:15657054 source Swiss-Prot : SWS_FT_FI4 26) chain B residue 261 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:15657054 source Swiss-Prot : SWS_FT_FI4

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