eF-site ID 1yxu-A
PDB Code 1yxu
Chain A

click to enlarge
Title Crystal Structure of Kinase Pim1 in Complex with AMP
Classification TRANSFERASE
Compound Proto-oncogene serine/threonine-protein kinase Pim-1
Source Homo sapiens (Human) (PIM1_HUMAN)
Sequence A:  PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKD
RISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFER
PDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL
EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGAL
LKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILL
YDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLA
LRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLH
Description


Functional site

1) chain A
residue 130
type
sequence F
description BINDING SITE FOR RESIDUE IMD A 500
source : AC1

2) chain A
residue 134
type
sequence T
description BINDING SITE FOR RESIDUE IMD A 500
source : AC1

3) chain A
residue 170
type
sequence D
description BINDING SITE FOR RESIDUE IMD A 500
source : AC1

4) chain A
residue 234
type
sequence D
description BINDING SITE FOR RESIDUE IMD A 500
source : AC1

5) chain A
residue 238
type
sequence G
description BINDING SITE FOR RESIDUE IMD A 500
source : AC1

6) chain A
residue 239
type
sequence D
description BINDING SITE FOR RESIDUE IMD A 500
source : AC1

7) chain A
residue 44
type
sequence L
description BINDING SITE FOR RESIDUE AMP A 550
source : AC5

8) chain A
residue 49
type
sequence F
description BINDING SITE FOR RESIDUE AMP A 550
source : AC5

9) chain A
residue 65
type
sequence A
description BINDING SITE FOR RESIDUE AMP A 550
source : AC5

10) chain A
residue 67
type
sequence K
description BINDING SITE FOR RESIDUE AMP A 550
source : AC5

11) chain A
residue 89
type
sequence E
description BINDING SITE FOR RESIDUE AMP A 550
source : AC5

12) chain A
residue 104
type
sequence I
description BINDING SITE FOR RESIDUE AMP A 550
source : AC5

13) chain A
residue 120
type
sequence L
description BINDING SITE FOR RESIDUE AMP A 550
source : AC5

14) chain A
residue 171
type
sequence E
description BINDING SITE FOR RESIDUE AMP A 550
source : AC5

15) chain A
residue 172
type
sequence N
description BINDING SITE FOR RESIDUE AMP A 550
source : AC5

16) chain A
residue 174
type
sequence L
description BINDING SITE FOR RESIDUE AMP A 550
source : AC5

17) chain A
residue 185
type
sequence I
description BINDING SITE FOR RESIDUE AMP A 550
source : AC5

18) chain A
residue 186
type
sequence D
description BINDING SITE FOR RESIDUE AMP A 550
source : AC5

19) chain A
residue 44-67
type prosite
sequence LGSGGFGSVYSGIRVSDNLPVAIK
description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGGFGSVYsGirvsdnlp..........VAIK
source prosite : PS00107

20) chain A
residue 163-175
type prosite
sequence VLHRDIKDENILI
description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDIKdeNILI
source prosite : PS00108

21) chain A
residue 167
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
source Swiss-Prot : SWS_FT_FI1

22) chain A
residue 44
type BINDING
sequence L
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

23) chain A
residue 67
type BINDING
sequence K
description BINDING => ECO:0000305|PubMed:15525646, ECO:0000305|PubMed:15657054, ECO:0000305|PubMed:15808862
source Swiss-Prot : SWS_FT_FI3

24) chain A
residue 121
type BINDING
sequence E
description BINDING => ECO:0000305|PubMed:15525646, ECO:0000305|PubMed:15657054, ECO:0000305|PubMed:15808862
source Swiss-Prot : SWS_FT_FI3

25) chain A
residue 128
type BINDING
sequence D
description BINDING => ECO:0000305|PubMed:15525646, ECO:0000305|PubMed:15657054, ECO:0000305|PubMed:15808862
source Swiss-Prot : SWS_FT_FI3

26) chain A
residue 98
type MOD_RES
sequence S
description Phosphoserine => ECO:0000269|PubMed:15657054
source Swiss-Prot : SWS_FT_FI4

27) chain A
residue 261
type MOD_RES
sequence S
description Phosphoserine => ECO:0000269|PubMed:15657054
source Swiss-Prot : SWS_FT_FI4


Display surface

Download
Links