eF-site ID 1yvf-A PDB Code 1yvf Chain A click to enlarge Title Hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00729145 Classification TRANSFERASE Compound HCV NS5B POLYMERASE Source (O93077_9HEPC) Sequence A:  MSMSYTWTGALITPCAAEESKLPINALSNSLLRHHNLVYS TTSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVK AKLLSVEEACKLTPPHSAKSKFGYGAKDVRSLSSRAVNHI RSVWKDLLEDTDTPIQTTIMAKNEVFCVQPEKGGRKPARL IVFPDLGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPKQ RVEFLVNTWKAKKCPMGFSYDTRCFDSTVTENDIRVEESI YQCCDLAPEARQAIRSLTERLYVGGPMTNSKGQNCGYRRC RASGVLTTSCGNTLTCYLKAAAACRAAKLQDCTMLVNGDD LVVICESAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEYD LELITSCSSNVSVAHDASGKRVYYLTRDPTVPLARAAWET ARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQL EKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSP GEINRVASCLRKLGVPPLRVWRHRARSVRAKLLSQGGRAA ICGKYLFNWAVRTKLKLTPIPAASRLLLSGWFVAGYSGGD IYHS Description Functional site 1) chain A residue 480 type sequence G description BINDING SITE FOR RESIDUE PO4 A 702 source : AC1 2) chain A residue 481 type sequence E description BINDING SITE FOR RESIDUE PO4 A 702 source : AC1 3) chain A residue 483 type sequence N description BINDING SITE FOR RESIDUE PO4 A 702 source : AC1 4) chain A residue 480 type sequence G description BINDING SITE FOR RESIDUE CL A 701 source : AC2 5) chain A residue 480 type sequence G description BINDING SITE FOR RESIDUE CL A 701 source : AC2 6) chain A residue 200 type sequence R description BINDING SITE FOR RESIDUE PH7 A 800 source : AC3 7) chain A residue 316 type sequence N description BINDING SITE FOR RESIDUE PH7 A 800 source : AC3 8) chain A residue 366 type sequence C description BINDING SITE FOR RESIDUE PH7 A 800 source : AC3 9) chain A residue 368 type sequence S description BINDING SITE FOR RESIDUE PH7 A 800 source : AC3 10) chain A residue 384 type sequence L description BINDING SITE FOR RESIDUE PH7 A 800 source : AC3 11) chain A residue 411 type sequence N description BINDING SITE FOR RESIDUE PH7 A 800 source : AC3 12) chain A residue 414 type sequence M description BINDING SITE FOR RESIDUE PH7 A 800 source : AC3 13) chain A residue 446 type sequence Q description BINDING SITE FOR RESIDUE PH7 A 800 source : AC3 14) chain A residue 448 type sequence Y description BINDING SITE FOR RESIDUE PH7 A 800 source : AC3 15) chain A residue 556 type sequence S description BINDING SITE FOR RESIDUE PH7 A 800 source : AC3 16) chain A residue 168 type sequence R description BINDING SITE FOR RESIDUE GOL A 600 source : AC4 17) chain A residue 83 type sequence L description BINDING SITE FOR RESIDUE GOL A 601 source : AC5 18) chain A residue 120 type sequence R description BINDING SITE FOR RESIDUE GOL A 601 source : AC5 19) chain A residue 123 type sequence W description BINDING SITE FOR RESIDUE GOL A 601 source : AC5 20) chain A residue 248 type sequence E description BINDING SITE FOR RESIDUE GOL A 601 source : AC5 21) chain A residue 319 type sequence D description BINDING SITE FOR RESIDUE GOL A 602 source : AC6 22) chain A residue 366 type sequence C description BINDING SITE FOR RESIDUE GOL A 602 source : AC6 23) chain A residue 367 type sequence S description BINDING SITE FOR RESIDUE GOL A 602 source : AC6 24) chain A residue 497 type sequence L description BINDING SITE FOR RESIDUE GOL A 605 source : AC7

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