eF-site ID 1ytw-A
PDB Code 1ytw
Chain A

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Title YERSINIA PTPASE COMPLEXED WITH TUNGSTATE
Classification HYDROLASE
Compound YERSINIA PROTEIN TYROSINE PHOSPHATASE
Source Yersinia enterocolitica (YOPH_YEREN)
Sequence A:  VSPYGPEARAELSSRLTTLRNTLAPATNDPRYLQACGGEK
LNRFRDIQCRRQTAVRADLNANYIQVGNTRTIACQYPLQS
QLESHFRMLAENRTPVLAVLASSSEIANQRFGMPDYFRQS
GTYGSITVESKMTQQVGLGDGIMADMYTLTIREAGQKTIS
VPVVHVGNWPDQTAVSSEVTKALASLVDQTAETKRNMYES
KGSSAVADDSKLRPVIHCRAGVGRTAQLIGAMCMNDSRNS
QLSVEDMVSQMRVQRNGIMVQKDEQLDVLIKLAEGQGRPL
LNS
Description


Functional site

1) chain A
residue 402
type
sequence H
description THE PHOSPHATE-BINDING LOOP CONTAINING THE CATALYTIC CONSENSUS SEQUENCE AND CYSTEINE NUCLEOPHILE.
source : PL

2) chain A
residue 403
type
sequence C
description THE PHOSPHATE-BINDING LOOP CONTAINING THE CATALYTIC CONSENSUS SEQUENCE AND CYSTEINE NUCLEOPHILE.
source : PL

3) chain A
residue 404
type
sequence R
description THE PHOSPHATE-BINDING LOOP CONTAINING THE CATALYTIC CONSENSUS SEQUENCE AND CYSTEINE NUCLEOPHILE.
source : PL

4) chain A
residue 405
type
sequence A
description THE PHOSPHATE-BINDING LOOP CONTAINING THE CATALYTIC CONSENSUS SEQUENCE AND CYSTEINE NUCLEOPHILE.
source : PL

5) chain A
residue 406
type
sequence G
description THE PHOSPHATE-BINDING LOOP CONTAINING THE CATALYTIC CONSENSUS SEQUENCE AND CYSTEINE NUCLEOPHILE.
source : PL

6) chain A
residue 407
type
sequence V
description THE PHOSPHATE-BINDING LOOP CONTAINING THE CATALYTIC CONSENSUS SEQUENCE AND CYSTEINE NUCLEOPHILE.
source : PL

7) chain A
residue 408
type
sequence G
description THE PHOSPHATE-BINDING LOOP CONTAINING THE CATALYTIC CONSENSUS SEQUENCE AND CYSTEINE NUCLEOPHILE.
source : PL

8) chain A
residue 409
type
sequence R
description THE PHOSPHATE-BINDING LOOP CONTAINING THE CATALYTIC CONSENSUS SEQUENCE AND CYSTEINE NUCLEOPHILE.
source : PL

9) chain A
residue 410
type
sequence T
description THE PHOSPHATE-BINDING LOOP CONTAINING THE CATALYTIC CONSENSUS SEQUENCE AND CYSTEINE NUCLEOPHILE.
source : PL

10) chain A
residue 350
type
sequence H
description THE FLEXIBLE LOOP CONTAINING THE PUTATIVE GENERAL ACID, ASP 356, THAT FOLDS OVER THE ACTIVE SITE AND SEQUESTERS THE ANION OR PHOSPHOTYR SUBSTRATE.
source : WPD

11) chain A
residue 351
type
sequence V
description THE FLEXIBLE LOOP CONTAINING THE PUTATIVE GENERAL ACID, ASP 356, THAT FOLDS OVER THE ACTIVE SITE AND SEQUESTERS THE ANION OR PHOSPHOTYR SUBSTRATE.
source : WPD

12) chain A
residue 352
type
sequence G
description THE FLEXIBLE LOOP CONTAINING THE PUTATIVE GENERAL ACID, ASP 356, THAT FOLDS OVER THE ACTIVE SITE AND SEQUESTERS THE ANION OR PHOSPHOTYR SUBSTRATE.
source : WPD

13) chain A
residue 353
type
sequence N
description THE FLEXIBLE LOOP CONTAINING THE PUTATIVE GENERAL ACID, ASP 356, THAT FOLDS OVER THE ACTIVE SITE AND SEQUESTERS THE ANION OR PHOSPHOTYR SUBSTRATE.
source : WPD

14) chain A
residue 354
type
sequence W
description THE FLEXIBLE LOOP CONTAINING THE PUTATIVE GENERAL ACID, ASP 356, THAT FOLDS OVER THE ACTIVE SITE AND SEQUESTERS THE ANION OR PHOSPHOTYR SUBSTRATE.
source : WPD

15) chain A
residue 355
type
sequence P
description THE FLEXIBLE LOOP CONTAINING THE PUTATIVE GENERAL ACID, ASP 356, THAT FOLDS OVER THE ACTIVE SITE AND SEQUESTERS THE ANION OR PHOSPHOTYR SUBSTRATE.
source : WPD

16) chain A
residue 356
type
sequence D
description THE FLEXIBLE LOOP CONTAINING THE PUTATIVE GENERAL ACID, ASP 356, THAT FOLDS OVER THE ACTIVE SITE AND SEQUESTERS THE ANION OR PHOSPHOTYR SUBSTRATE.
source : WPD

17) chain A
residue 357
type
sequence Q
description THE FLEXIBLE LOOP CONTAINING THE PUTATIVE GENERAL ACID, ASP 356, THAT FOLDS OVER THE ACTIVE SITE AND SEQUESTERS THE ANION OR PHOSPHOTYR SUBSTRATE.
source : WPD

18) chain A
residue 358
type
sequence T
description THE FLEXIBLE LOOP CONTAINING THE PUTATIVE GENERAL ACID, ASP 356, THAT FOLDS OVER THE ACTIVE SITE AND SEQUESTERS THE ANION OR PHOSPHOTYR SUBSTRATE.
source : WPD

19) chain A
residue 359
type
sequence A
description THE FLEXIBLE LOOP CONTAINING THE PUTATIVE GENERAL ACID, ASP 356, THAT FOLDS OVER THE ACTIVE SITE AND SEQUESTERS THE ANION OR PHOSPHOTYR SUBSTRATE.
source : WPD

20) chain A
residue 360
type
sequence V
description THE FLEXIBLE LOOP CONTAINING THE PUTATIVE GENERAL ACID, ASP 356, THAT FOLDS OVER THE ACTIVE SITE AND SEQUESTERS THE ANION OR PHOSPHOTYR SUBSTRATE.
source : WPD

21) chain A
residue 356
type
sequence D
description BINDING SITE FOR RESIDUE WO4 A 1
source : AC1

22) chain A
residue 357
type
sequence Q
description BINDING SITE FOR RESIDUE WO4 A 1
source : AC1

23) chain A
residue 403
type
sequence C
description BINDING SITE FOR RESIDUE WO4 A 1
source : AC1

24) chain A
residue 404
type
sequence R
description BINDING SITE FOR RESIDUE WO4 A 1
source : AC1

25) chain A
residue 405
type
sequence A
description BINDING SITE FOR RESIDUE WO4 A 1
source : AC1

26) chain A
residue 406
type
sequence G
description BINDING SITE FOR RESIDUE WO4 A 1
source : AC1

27) chain A
residue 407
type
sequence V
description BINDING SITE FOR RESIDUE WO4 A 1
source : AC1

28) chain A
residue 408
type
sequence G
description BINDING SITE FOR RESIDUE WO4 A 1
source : AC1

29) chain A
residue 409
type
sequence R
description BINDING SITE FOR RESIDUE WO4 A 1
source : AC1

30) chain A
residue 446
type
sequence Q
description BINDING SITE FOR RESIDUE WO4 A 1
source : AC1

31) chain A
residue 278
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 3
source : AC2

32) chain A
residue 342
type
sequence K
description BINDING SITE FOR RESIDUE SO4 A 3
source : AC2

33) chain A
residue 388
type
sequence S
description BINDING SITE FOR RESIDUE SO4 A 3
source : AC2

34) chain A
residue 389
type
sequence S
description BINDING SITE FOR RESIDUE SO4 A 3
source : AC2

35) chain A
residue 290
type catalytic
sequence E
description 47
source MCSA : MCSA1

36) chain A
residue 354
type catalytic
sequence W
description 47
source MCSA : MCSA1

37) chain A
residue 356
type catalytic
sequence D
description 47
source MCSA : MCSA1

38) chain A
residue 402
type catalytic
sequence H
description 47
source MCSA : MCSA1

39) chain A
residue 403
type catalytic
sequence C
description 47
source MCSA : MCSA1

40) chain A
residue 409
type catalytic
sequence R
description 47
source MCSA : MCSA1

41) chain A
residue 410
type catalytic
sequence T
description 47
source MCSA : MCSA1

42) chain A
residue 403
type ACT_SITE
sequence C
description Phosphocysteine intermediate
source Swiss-Prot : SWS_FT_FI1

43) chain A
residue 401-411
type prosite
sequence IHCRAGVGRTA
description TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. IHCraGvgRTA
source prosite : PS00383


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