eF-site ID 1ysx-A
PDB Code 1ysx
Chain A

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Title Solution structure of domain 3 from human serum albumin complexed to an anti-apoptotic ligand directed against Bcl-xL and Bcl-2
Classification APOPTOSIS
Compound Serum albumin
Source Homo sapiens (Human) (ALBU_HUMAN)
Sequence A:  QNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLV
EVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLH
EKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNA
ETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQL
KAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALG
Description


Functional site

1) chain A
residue 391
type
sequence N
description BINDING SITE FOR RESIDUE 4EB A 1000
source : AC1

2) chain A
residue 392
type
sequence C
description BINDING SITE FOR RESIDUE 4EB A 1000
source : AC1

3) chain A
residue 407
type
sequence L
description BINDING SITE FOR RESIDUE 4EB A 1000
source : AC1

4) chain A
residue 411
type
sequence Y
description BINDING SITE FOR RESIDUE 4EB A 1000
source : AC1

5) chain A
residue 414
type
sequence K
description BINDING SITE FOR RESIDUE 4EB A 1000
source : AC1

6) chain A
residue 415
type
sequence V
description BINDING SITE FOR RESIDUE 4EB A 1000
source : AC1

7) chain A
residue 422
type
sequence T
description BINDING SITE FOR RESIDUE 4EB A 1000
source : AC1

8) chain A
residue 423
type
sequence L
description BINDING SITE FOR RESIDUE 4EB A 1000
source : AC1

9) chain A
residue 426
type
sequence V
description BINDING SITE FOR RESIDUE 4EB A 1000
source : AC1

10) chain A
residue 452
type
sequence Y
description BINDING SITE FOR RESIDUE 4EB A 1000
source : AC1

11) chain A
residue 460
type
sequence L
description BINDING SITE FOR RESIDUE 4EB A 1000
source : AC1

12) chain A
residue 464
type
sequence H
description BINDING SITE FOR RESIDUE 4EB A 1000
source : AC1

13) chain A
residue 551-575
type prosite
sequence FAAFVEKCCKADDKETCFAEEGKKL
description ALBUMIN_1 Albumin domain signature. FaafvekCCkaDdketCFaeegkkL
source prosite : PS00212

14) chain A
residue 389
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI1

15) chain A
residue 524
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI1

16) chain A
residue 538
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI1

17) chain A
residue 541
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI1

18) chain A
residue 557
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI1

19) chain A
residue 560
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI1

20) chain A
residue 564
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI1

21) chain A
residue 574
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI1

22) chain A
residue 402
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI1

23) chain A
residue 414
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI1

24) chain A
residue 432
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI1

25) chain A
residue 436
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI1

26) chain A
residue 466
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI1

27) chain A
residue 475
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI1

28) chain A
residue 500
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI1

29) chain A
residue 519
type SITE
sequence K
description Not glycated => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI1

30) chain A
residue 525
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:15047055, ECO:0000269|PubMed:3759977, ECO:0000269|PubMed:6706980, ECO:0000269|PubMed:6853480
source Swiss-Prot : SWS_FT_FI10

31) chain A
residue 534
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:3759977
source Swiss-Prot : SWS_FT_FI11

32) chain A
residue 419
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:19690332
source Swiss-Prot : SWS_FT_FI2

33) chain A
residue 420
type MOD_RES
sequence T
description Phosphothreonine => ECO:0007744|PubMed:19690332
source Swiss-Prot : SWS_FT_FI3

34) chain A
residue 422
type MOD_RES
sequence T
description Phosphothreonine => ECO:0007744|PubMed:19690332
source Swiss-Prot : SWS_FT_FI3

35) chain A
residue 436
type MOD_RES
sequence K
description N6-succinyllysine => ECO:0000250|UniProtKB:P07724
source Swiss-Prot : SWS_FT_FI4

36) chain A
residue 519
type MOD_RES
sequence K
description N6-succinyllysine => ECO:0000250|UniProtKB:P07724
source Swiss-Prot : SWS_FT_FI4

37) chain A
residue 564
type MOD_RES
sequence K
description N6-succinyllysine => ECO:0000250|UniProtKB:P07724
source Swiss-Prot : SWS_FT_FI4

38) chain A
residue 489
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI5

39) chain A
residue 534
type MOD_RES
sequence K
description N6-methyllysine; alternate => ECO:0007744|PubMed:24129315
source Swiss-Prot : SWS_FT_FI6

40) chain A
residue 413
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI7

41) chain A
residue 444
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI7

42) chain A
residue 536
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI7

43) chain A
residue 545
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI7

44) chain A
residue 573
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:15047055
source Swiss-Prot : SWS_FT_FI7

45) chain A
residue 439
type CARBOHYD
sequence K
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:3759977
source Swiss-Prot : SWS_FT_FI8

46) chain A
residue 494
type CARBOHYD
sequence D
description N-linked (GlcNAc...) asparagine; in variant Casebrook
source Swiss-Prot : SWS_FT_FI9


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