eF-site ID 1ysn-A PDB Code 1ysn Chain A click to enlarge Title Solution structure of the anti-apoptotic protein Bcl-xL complexed with an acyl-sulfonamide-based ligand Classification APOPTOSIS Compound Apoptosis regulator Bcl-X Source null (BCLX_HUMAN) Sequence A:  MSMAMSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTE APEGTESEAVKQALREAGDEFELRYRRAFSDLTSQLHITP GTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVD KEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYG NNAAAESRKGQERLEHHHHHH Description Functional site 1) chain A residue 97 type sequence A description BINDING SITE FOR RESIDUE 43B A 1000 source : AC1 2) chain A residue 100 type sequence E description BINDING SITE FOR RESIDUE 43B A 1000 source : AC1 3) chain A residue 104 type sequence R description BINDING SITE FOR RESIDUE 43B A 1000 source : AC1 4) chain A residue 105 type sequence Y description BINDING SITE FOR RESIDUE 43B A 1000 source : AC1 5) chain A residue 108 type sequence A description BINDING SITE FOR RESIDUE 43B A 1000 source : AC1 6) chain A residue 112 type sequence L description BINDING SITE FOR RESIDUE 43B A 1000 source : AC1 7) chain A residue 115 type sequence Q description BINDING SITE FOR RESIDUE 43B A 1000 source : AC1 8) chain A residue 130 type sequence V description BINDING SITE FOR RESIDUE 43B A 1000 source : AC1 9) chain A residue 133 type sequence E description BINDING SITE FOR RESIDUE 43B A 1000 source : AC1 10) chain A residue 134 type sequence L description BINDING SITE FOR RESIDUE 43B A 1000 source : AC1 11) chain A residue 140 type sequence N description BINDING SITE FOR RESIDUE 43B A 1000 source : AC1 12) chain A residue 141 type sequence W description BINDING SITE FOR RESIDUE 43B A 1000 source : AC1 13) chain A residue 142 type sequence G description BINDING SITE FOR RESIDUE 43B A 1000 source : AC1 14) chain A residue 143 type sequence R description BINDING SITE FOR RESIDUE 43B A 1000 source : AC1 15) chain A residue 145 type sequence V description BINDING SITE FOR RESIDUE 43B A 1000 source : AC1 16) chain A residue 146 type sequence A description BINDING SITE FOR RESIDUE 43B A 1000 source : AC1 17) chain A residue 195 type sequence F description BINDING SITE FOR RESIDUE 43B A 1000 source : AC1 18) chain A residue 199 type sequence Y description BINDING SITE FOR RESIDUE 43B A 1000 source : AC1 19) chain A residue 93 type MOD_RES sequence A description Phosphoserine; by PLK3 => ECO:0000269|PubMed:21840391 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 106 type MOD_RES sequence R description Phosphoserine; by CDK1 => ECO:0000269|PubMed:19917720 source Swiss-Prot : SWS_FT_FI3 21) chain A residue 134-152 type prosite sequence LFRDGVNWGRIVAFFSFGG description BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFsFGG source prosite : PS01080 22) chain A residue 185-196 type prosite sequence WIQENGGWDTFV description BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqenGGWDtFV source prosite : PS01258 23) chain A residue 90-104 type prosite sequence VKQALREAGDEFELR description BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VkqaLReAGDEFELR source prosite : PS01259 24) chain A residue 8-28 type prosite sequence SNRELVVDFLSYKLSQKGYSW description BH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. SNRELVvDFLSYKLSQKGYsW source prosite : PS01260 25) chain A residue 105 type SITE sequence Y description Cleavage; by caspase-1 source Swiss-Prot : SWS_FT_FI1

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