eF-site ID 1ysd-A PDB Code 1ysd Chain A click to enlarge Title Yeast Cytosine Deaminase Double Mutant Classification HYDROLASE Compound Cytosine deaminase Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (FCY1_YEAST) Sequence A:  TGGMASKWDQKGMDIAYEEALLGYKEGGVPIGGCLINNKD GSVLGRGHNMRFQKGSATLHGEISTLENCGRLEGKVYKDT TLYTTLSPCDMCTGAIIMYGIPRCVVGENVNFKSKGEKYL QTRGHEVVVVDDERCKKLMKQFIDERPQDWFEDIGE Description Functional site 1) chain A residue 64 type sequence E description BINDING SITE FOR RESIDUE ZN A 500 source : AC1 2) chain A residue 62 type sequence H description BINDING SITE FOR RESIDUE ZN A 501 source : AC2 3) chain A residue 91 type sequence C description BINDING SITE FOR RESIDUE ZN A 501 source : AC2 4) chain A residue 94 type sequence C description BINDING SITE FOR RESIDUE ZN A 501 source : AC2 5) chain A residue 64 type ACT_SITE sequence E description Proton donor => ECO:0000269|PubMed:12637534, ECO:0007744|PDB:1UAQ source Swiss-Prot : SWS_FT_FI1 6) chain A residue 51 type BINDING sequence N description BINDING => ECO:0000269|PubMed:12637534, ECO:0000269|PubMed:12906827, ECO:0007744|PDB:1P6O, ECO:0007744|PDB:1UAQ source Swiss-Prot : SWS_FT_FI2 7) chain A residue 155 type BINDING sequence D description BINDING => ECO:0000269|PubMed:12637534, ECO:0000269|PubMed:12906827, ECO:0007744|PDB:1P6O, ECO:0007744|PDB:1UAQ source Swiss-Prot : SWS_FT_FI2 8) chain A residue 62 type BINDING sequence H description BINDING => ECO:0000269|PubMed:12637534, ECO:0000269|PubMed:12906827, ECO:0000269|PubMed:15879217, ECO:0007744|PDB:1OX7, ECO:0007744|PDB:1P6O, ECO:0007744|PDB:1RB7, ECO:0007744|PDB:1UAQ, ECO:0007744|PDB:1YSB, ECO:0007744|PDB:1YSD source Swiss-Prot : SWS_FT_FI3 9) chain A residue 91 type BINDING sequence C description BINDING => ECO:0000269|PubMed:12637534, ECO:0000269|PubMed:12906827, ECO:0000269|PubMed:15879217, ECO:0007744|PDB:1OX7, ECO:0007744|PDB:1P6O, ECO:0007744|PDB:1RB7, ECO:0007744|PDB:1UAQ, ECO:0007744|PDB:1YSB, ECO:0007744|PDB:1YSD source Swiss-Prot : SWS_FT_FI3 10) chain A residue 94 type BINDING sequence C description BINDING => ECO:0000269|PubMed:12637534, ECO:0000269|PubMed:12906827, ECO:0000269|PubMed:15879217, ECO:0007744|PDB:1OX7, ECO:0007744|PDB:1P6O, ECO:0007744|PDB:1RB7, ECO:0007744|PDB:1UAQ, ECO:0007744|PDB:1YSB, ECO:0007744|PDB:1YSD source Swiss-Prot : SWS_FT_FI3 11) chain A residue 62-98 type prosite sequence HGEISTLENCGRLEGKVYKDTTLYTTLSPCDMCTGAI description CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HGEisTLencgrlegkvykdttlyttls............PCdm......CtgaI source prosite : PS00903 12) chain A residue 62 type catalytic sequence H description 636 source MCSA : MCSA1 13) chain A residue 64 type catalytic sequence E description 636 source MCSA : MCSA1 14) chain A residue 89 type catalytic sequence S description 636 source MCSA : MCSA1 15) chain A residue 91 type catalytic sequence C description 636 source MCSA : MCSA1 16) chain A residue 94 type catalytic sequence C description 636 source MCSA : MCSA1

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