eF-site ID 1ypt-AB
PDB Code 1ypt
Chain A, B

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Title CRYSTAL STRUCTURE OF YERSINIA PROTEIN TYROSINE PHOSPHATASE AT 2.5 ANGSTROMS AND THE COMPLEX WITH TUNGSTATE
Classification HYDROLASE
Compound PROTEIN-TYROSINE PHOSPHATASE YERSINIA (CATALYTIC DOMAIN)
Source Yersinia enterocolitica (YOPH_YEREN)
Sequence A:  PEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKLNRFR
DIQCRRQTAVRADLNANYIQVGNTRTIACQYPLQSQLESH
FRMLAENRTPVLAVLASSSEIANQRFGMPDYFRQSGTYGS
ITVESKMTQQVGLGDGIMADMYTLTIREAGQKTISVPVVH
VGNWPDQTAVSSEVTKALASLVDQTAETKRNMYESKGSSA
VADDSKLRPVIHCRAGVGRTAQLIGAMCMNDSRNSQLSVE
DMVSQMRVQRNGIMVQKDEQLDVLIKLAEGQGRPLLNS
B:  YGPEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKLNR
FRDIQCRRQTAVRADLNANYIQVGNTRTIACQYPLQSQLE
SHFRMLAENRTPVLAVLASSSEIANQRFGMPDYFRQSGTY
GSITVESKMTQQVGLGDGIMADMYTLTIREAGQKTISVPV
VHVGNWPDQTAVSSEVTKALASLVDQTAETKRNMYESKGS
SAVADDSKLRPVIHCRAGVGRTAQLIGAMCMNDSRNSQLS
VEDMVSQMRVQRNGIMVQKDEQLDVLIKLAEGQGRPLLNS
Description


Functional site

1) chain A
residue 402
type
sequence H
description THE PHOSPHATE BINDING LOOP WHICH IS BELIEVED TO BE STRUCTURALLY CONSERVED IN ALL PROTEIN TYROSINE PHOSPHATASES
source : APL

2) chain A
residue 403
type
sequence C
description THE PHOSPHATE BINDING LOOP WHICH IS BELIEVED TO BE STRUCTURALLY CONSERVED IN ALL PROTEIN TYROSINE PHOSPHATASES
source : APL

3) chain A
residue 404
type
sequence R
description THE PHOSPHATE BINDING LOOP WHICH IS BELIEVED TO BE STRUCTURALLY CONSERVED IN ALL PROTEIN TYROSINE PHOSPHATASES
source : APL

4) chain A
residue 405
type
sequence A
description THE PHOSPHATE BINDING LOOP WHICH IS BELIEVED TO BE STRUCTURALLY CONSERVED IN ALL PROTEIN TYROSINE PHOSPHATASES
source : APL

5) chain A
residue 406
type
sequence G
description THE PHOSPHATE BINDING LOOP WHICH IS BELIEVED TO BE STRUCTURALLY CONSERVED IN ALL PROTEIN TYROSINE PHOSPHATASES
source : APL

6) chain A
residue 407
type
sequence V
description THE PHOSPHATE BINDING LOOP WHICH IS BELIEVED TO BE STRUCTURALLY CONSERVED IN ALL PROTEIN TYROSINE PHOSPHATASES
source : APL

7) chain A
residue 408
type
sequence G
description THE PHOSPHATE BINDING LOOP WHICH IS BELIEVED TO BE STRUCTURALLY CONSERVED IN ALL PROTEIN TYROSINE PHOSPHATASES
source : APL

8) chain A
residue 409
type
sequence R
description THE PHOSPHATE BINDING LOOP WHICH IS BELIEVED TO BE STRUCTURALLY CONSERVED IN ALL PROTEIN TYROSINE PHOSPHATASES
source : APL

9) chain A
residue 410
type
sequence T
description THE PHOSPHATE BINDING LOOP WHICH IS BELIEVED TO BE STRUCTURALLY CONSERVED IN ALL PROTEIN TYROSINE PHOSPHATASES
source : APL

10) chain B
residue 402
type
sequence H
description THE PHOSPHATE BINDING LOOP WHICH IS BELIEVED TO BE STRUCTURALLY CONSERVED IN ALL PROTEIN TYROSINE PHOSPHATASES
source : BPL

11) chain B
residue 403
type
sequence C
description THE PHOSPHATE BINDING LOOP WHICH IS BELIEVED TO BE STRUCTURALLY CONSERVED IN ALL PROTEIN TYROSINE PHOSPHATASES
source : BPL

12) chain B
residue 404
type
sequence R
description THE PHOSPHATE BINDING LOOP WHICH IS BELIEVED TO BE STRUCTURALLY CONSERVED IN ALL PROTEIN TYROSINE PHOSPHATASES
source : BPL

13) chain B
residue 405
type
sequence A
description THE PHOSPHATE BINDING LOOP WHICH IS BELIEVED TO BE STRUCTURALLY CONSERVED IN ALL PROTEIN TYROSINE PHOSPHATASES
source : BPL

14) chain B
residue 406
type
sequence G
description THE PHOSPHATE BINDING LOOP WHICH IS BELIEVED TO BE STRUCTURALLY CONSERVED IN ALL PROTEIN TYROSINE PHOSPHATASES
source : BPL

15) chain B
residue 407
type
sequence V
description THE PHOSPHATE BINDING LOOP WHICH IS BELIEVED TO BE STRUCTURALLY CONSERVED IN ALL PROTEIN TYROSINE PHOSPHATASES
source : BPL

16) chain B
residue 408
type
sequence G
description THE PHOSPHATE BINDING LOOP WHICH IS BELIEVED TO BE STRUCTURALLY CONSERVED IN ALL PROTEIN TYROSINE PHOSPHATASES
source : BPL

17) chain B
residue 409
type
sequence R
description THE PHOSPHATE BINDING LOOP WHICH IS BELIEVED TO BE STRUCTURALLY CONSERVED IN ALL PROTEIN TYROSINE PHOSPHATASES
source : BPL

18) chain B
residue 410
type
sequence T
description THE PHOSPHATE BINDING LOOP WHICH IS BELIEVED TO BE STRUCTURALLY CONSERVED IN ALL PROTEIN TYROSINE PHOSPHATASES
source : BPL

19) chain B
residue 350
type
sequence H
description THE FLEXIBLE LOOP FROM MOLECULE B CONTAINING THE PUTATIVE GENERAL ACID, ASP 356, THAT FOLDS OVER THE ACTIVE SITE AND SEQUESTERS THE TUNGSTATE ANION IN THE TUNGSTATE-BOUND STRUCTURE.
source : WPD

20) chain B
residue 351
type
sequence V
description THE FLEXIBLE LOOP FROM MOLECULE B CONTAINING THE PUTATIVE GENERAL ACID, ASP 356, THAT FOLDS OVER THE ACTIVE SITE AND SEQUESTERS THE TUNGSTATE ANION IN THE TUNGSTATE-BOUND STRUCTURE.
source : WPD

21) chain B
residue 352
type
sequence G
description THE FLEXIBLE LOOP FROM MOLECULE B CONTAINING THE PUTATIVE GENERAL ACID, ASP 356, THAT FOLDS OVER THE ACTIVE SITE AND SEQUESTERS THE TUNGSTATE ANION IN THE TUNGSTATE-BOUND STRUCTURE.
source : WPD

22) chain B
residue 353
type
sequence N
description THE FLEXIBLE LOOP FROM MOLECULE B CONTAINING THE PUTATIVE GENERAL ACID, ASP 356, THAT FOLDS OVER THE ACTIVE SITE AND SEQUESTERS THE TUNGSTATE ANION IN THE TUNGSTATE-BOUND STRUCTURE.
source : WPD

23) chain B
residue 354
type
sequence W
description THE FLEXIBLE LOOP FROM MOLECULE B CONTAINING THE PUTATIVE GENERAL ACID, ASP 356, THAT FOLDS OVER THE ACTIVE SITE AND SEQUESTERS THE TUNGSTATE ANION IN THE TUNGSTATE-BOUND STRUCTURE.
source : WPD

24) chain B
residue 355
type
sequence P
description THE FLEXIBLE LOOP FROM MOLECULE B CONTAINING THE PUTATIVE GENERAL ACID, ASP 356, THAT FOLDS OVER THE ACTIVE SITE AND SEQUESTERS THE TUNGSTATE ANION IN THE TUNGSTATE-BOUND STRUCTURE.
source : WPD

25) chain B
residue 356
type
sequence D
description THE FLEXIBLE LOOP FROM MOLECULE B CONTAINING THE PUTATIVE GENERAL ACID, ASP 356, THAT FOLDS OVER THE ACTIVE SITE AND SEQUESTERS THE TUNGSTATE ANION IN THE TUNGSTATE-BOUND STRUCTURE.
source : WPD

26) chain B
residue 357
type
sequence Q
description THE FLEXIBLE LOOP FROM MOLECULE B CONTAINING THE PUTATIVE GENERAL ACID, ASP 356, THAT FOLDS OVER THE ACTIVE SITE AND SEQUESTERS THE TUNGSTATE ANION IN THE TUNGSTATE-BOUND STRUCTURE.
source : WPD

27) chain B
residue 358
type
sequence T
description THE FLEXIBLE LOOP FROM MOLECULE B CONTAINING THE PUTATIVE GENERAL ACID, ASP 356, THAT FOLDS OVER THE ACTIVE SITE AND SEQUESTERS THE TUNGSTATE ANION IN THE TUNGSTATE-BOUND STRUCTURE.
source : WPD

28) chain B
residue 359
type
sequence A
description THE FLEXIBLE LOOP FROM MOLECULE B CONTAINING THE PUTATIVE GENERAL ACID, ASP 356, THAT FOLDS OVER THE ACTIVE SITE AND SEQUESTERS THE TUNGSTATE ANION IN THE TUNGSTATE-BOUND STRUCTURE.
source : WPD

29) chain B
residue 360
type
sequence V
description THE FLEXIBLE LOOP FROM MOLECULE B CONTAINING THE PUTATIVE GENERAL ACID, ASP 356, THAT FOLDS OVER THE ACTIVE SITE AND SEQUESTERS THE TUNGSTATE ANION IN THE TUNGSTATE-BOUND STRUCTURE.
source : WPD

30) chain A
residue 290
type catalytic
sequence E
description 47
source MCSA : MCSA1

31) chain A
residue 354
type catalytic
sequence W
description 47
source MCSA : MCSA1

32) chain A
residue 356
type catalytic
sequence D
description 47
source MCSA : MCSA1

33) chain A
residue 402
type catalytic
sequence H
description 47
source MCSA : MCSA1

34) chain A
residue 403
type catalytic
sequence C
description 47
source MCSA : MCSA1

35) chain A
residue 409
type catalytic
sequence R
description 47
source MCSA : MCSA1

36) chain A
residue 410
type catalytic
sequence T
description 47
source MCSA : MCSA1

37) chain B
residue 290
type catalytic
sequence E
description 47
source MCSA : MCSA2

38) chain B
residue 354
type catalytic
sequence W
description 47
source MCSA : MCSA2

39) chain B
residue 356
type catalytic
sequence D
description 47
source MCSA : MCSA2

40) chain B
residue 402
type catalytic
sequence H
description 47
source MCSA : MCSA2

41) chain B
residue 403
type catalytic
sequence C
description 47
source MCSA : MCSA2

42) chain B
residue 409
type catalytic
sequence R
description 47
source MCSA : MCSA2

43) chain B
residue 410
type catalytic
sequence T
description 47
source MCSA : MCSA2

44) chain A
residue 403
type ACT_SITE
sequence C
description Phosphocysteine intermediate
source Swiss-Prot : SWS_FT_FI1

45) chain B
residue 403
type ACT_SITE
sequence C
description Phosphocysteine intermediate
source Swiss-Prot : SWS_FT_FI1

46) chain A
residue 401-411
type prosite
sequence IHCRAGVGRTA
description TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. IHCraGvgRTA
source prosite : PS00383


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