eF-site ID 1ynn-ABCDJK PDB Code 1ynn Chain A, B, C, D, J, K click to enlarge Title Taq RNA polymerase-rifampicin complex Classification TRANSFERASE Compound DNA-directed RNA polymerase alpha chain Source ORGANISM_SCIENTIFIC: Thermus aquaticus; Sequence A:  LKAPVFTATTQGDHYGEFVLEPLERGFGVTLGNPLRRILL SSIPGTAVTSVYIEDVLHEFSTIPGVKEDVVEIILNLKEL VVRFLDPKMASTTLILRAEGPKEVRAGDFTPSADVEIMNP DLHIATLEEGGKLYMEVRVDRGVGYVPAERHGIKDRINAI PVDAIFSPVRRVAFQVEDTRLGQRTDLDKLTLRIWTDGSV TPLEALNQAVAILKEHLNYFANPEASLLPT B:  SKLKAPVFTATTQGDHYGEFVLEPLERGFGVTLGNPLRRI LLSSIPGTAVTSVYIEDVLHEFSTIPGVKEDVVEIILNLK ELVVRFLDPKMASTTLILRAEGPKEVRAGDFTPSADVEIM NPDLHIATLEEGGKLYMEVRVDRGVGYVPAERHGIKDRIN AIPVDAIFSPVRRVAFQVEDTRLGQRTDLDKLTLRIWTDG SVTPLEALNQAVAILKEHLNYFANP C:  MEIKRFGRIREVIPLPPLTEIQVESYKKALQADVPPEKRE NVGIQAAFKETFPIEEGDKGKGGLVLDFLEYRIGDPPFSQ DECREKDLTYQAPLYARLQLIHKDTGLIKEDEVFLGHLPL MTEDGSFIINGADRVIVSQIHRSPGVYFTPDPARPGRYIA SIIPLPKRGPWIDLEVEASGVVTMKVNKRKFPLVLLLRVL GYDQETLVRELSAYGDLVQGLLDEAVLAMRPEEAMVRLFT LLRPGDPPKKDKALAYLFGLLADPKRYDLGEAGRYKAEEK LGVGLSGRTLVRFEDGEFKDEVFLPTLRYLFALTAGVPGH EVDDIDHLGNRRIRTVGELMADQFRVGLARLARGVRERMV MGSPDTLTPAKLVNSRPLEAALREFFSRSQLSQFKDETNP LSSLRHKRRISALGPGGLTRERAGFDVRDVHRTHYGRICP VETPEGANIGLITSLAAYARVDALGFIRTPYRRVKNGVVT EEVVYMTASEEDRYTIAQANTPLEGDRIATDRVVARRRGE PVIVAPEEVEFMDVSPKQVFSLNTNLIPFLEHDDANRALM GSNMQTQAVPLIRAQAPVVMTGLEERVVRDSLAALYAEED GEVVKVDGTRIAVRYEDGRLVEHPLRRYARSNQGTAFDQR PRVRVGQRVKKGDLLADGPASEEGFLALGQNVLVAIMPFD GYNFEDAIVISEELLKRDFYTSIHIERYEIEARDTKLGPE RITRDIPHLSEAALRDLDEEGIVRIGAEVKPGDILVGRTS FKGEQEPSPEERLLRSIFGEKARDVKDTSLRVPPGEGGIV VGRLRLRRGDPGVELKPGVREVVRVFVAQKRKLQVGDKLA NRHGNKGVVAKILPVEDMPHLPDGTPVDVILNPLGVPSRM NLGQILETHLGLAGYFLGQRYISPVFDGATEPEIKELLAE AFNLYFGKRQGEGFGVDKREKEVLARAEKLGLVSPGKSPE EQLKELFDLGKVVLYDGRTGEPFEGPIVVGQMFIMKLYHM VEDKMHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWAL EAYGAAHTLQEMLTIKSDDIEGRNAAYQAIIKGEDVPEPS VPESFRVLVKELQALALDVQTLDEKDNPVDIFEG D:  KEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPERD GLFDERIFGPIKDYECACGKYKRQRFEGKVCERCGVEVTR SIVRRYRMGHIELATPAAHIWFVKDVPSKIGTLLDLSATE LEQVLYFNKYIVLDPKGAVLDGVPVEKRQLLTDEEYRELR YGKQETYPLPAGVDALVKDGEEVVKGQELAPGVVSRMDGV ALYRFPRRVRVDYLRKERAALRIPLSAWVEKEAYRPGEVL AELSEPYLFRAEESGVVELKDLAEGHLIYLRQEEEVVARY FLPAGMTPLVVEGEIVEVGQPLAEGKGLLRLPRHMTAKEV EAEEEGDSVHLTLFLEWTEPKDYKVAPHMNVIVPEGAKVQ AGEKIVAAIDPEEEVIAEAEGVVHLHEPASILVVKARVYP FEDDVEVTTGDRVAPGDVLADGGKVKSEIYGRVEVDLVRN VVRVVESYDIDARMGAEAIQELLKELDLEKLERELLEEMK HPSRARRAKARKRLEVVRAFLDSGNRPEWMILEAVPVLPP DLRPMVQVDGGRFATSDLNDLYRRLINRNNRLKKLLAQGA PEIIIRNEKRMLQEAVDAVIDNGRRGSPVTNPGSERPLRS LTDILSGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQC GLPKRMALELFKPFLLKKMEEKAFAPNVKAARRMLERQRD IKDEVWDALEEVIHGKVVLLNRAPTLHRLGIQAFQPVLVE GQSIQLHPLVCEAFNADFDGDQMAVHVPLSSFAQAEARIQ MLSAHNLLSPASGEPLAKPSRDIILGLYYITQVRKEKKGA GMAFATPEEALAAYERGEVALNAPIVVAGRETSVGRLKFV FANPDEALLAVAHGLLDLQDVVTVRYLGRRLETSPGRILF ARIVGEAVGDEKVAQELIQMDVPQEKNSLKDLVYQAFLRL GMEKTARLLDALKYYGFTLSTTSGITIGIDDAVIPEEKQR YLEEADRKLRQIEQAYEMGFLTDRERYDQVIQLWTETTEK VTQAVFKNFEENYPFNPLYVMAQSGARGNPQQIRQLCGMR GLMQKPSGETFEVPVRSSFREGLTVLEYFISSHGARKGGA DTALRTADSGYLTRKLVDVAHEIVVREADCGTTNYISVPL FQMDEVTRTLRLRKRSDIESGLYGRVLAREVEALGRRLEE GRYLSLEDVHFLIKAAEAGEVREVPVRSPLTCQTRYGVCQ KCYGYDLSMARPVSIGEAVGVVAAESIGEPGTQLTMRT J:  TQGLPRVIELFEARRPKAKAVISEIDGVVRIEEGEDRLSV FVESEGFSKEYKLPKDARLLVKDGDYVEAGQPLTRGAIDP HQLLEAKGPEAVERYLVDEIQKVYRAQGVKLHDKHIEIVV RQMLKYVEVTDPGDSRLLEGQVLEKWDVEALNERLIAEGK VPVAWKPLLMGVTKSALSTKSWLSAASFQNTTHVLTEAAI AGKKDELIGLKENVILGRLIPAGTGSDFVRFTQVVDQRTL KAIEEARKE K:  MAEPGIDKLFGMVDSKYRLTVVVAKRAQQLLRHRFKNTVL EPEERPKMRTLEGLYDDPNAVTWAMKELLTGRLFFGENLV PEDRLQKEMERLYPT Description Functional site 1) chain D residue 58 type sequence C description BINDING SITE FOR RESIDUE ZN D 1525 source : AC1 2) chain D residue 59 type sequence A description BINDING SITE FOR RESIDUE ZN D 1525 source : AC1 3) chain D residue 60 type sequence C description BINDING SITE FOR RESIDUE ZN D 1525 source : AC1 4) chain D residue 76 type sequence C description BINDING SITE FOR RESIDUE ZN D 1525 source : AC1 5) chain D residue 1112 type sequence C description BINDING SITE FOR RESIDUE ZN D 1526 source : AC2 6) chain D residue 1194 type sequence C description BINDING SITE FOR RESIDUE ZN D 1526 source : AC2 7) chain D residue 1201 type sequence C description BINDING SITE FOR RESIDUE ZN D 1526 source : AC2 8) chain D residue 1204 type sequence C description BINDING SITE FOR RESIDUE ZN D 1526 source : AC2 9) chain C residue 390 type sequence Q description BINDING SITE FOR RESIDUE RFP C 1120 source : AC3 10) chain C residue 392 type sequence S description BINDING SITE FOR RESIDUE RFP C 1120 source : AC3 11) chain C residue 393 type sequence Q description BINDING SITE FOR RESIDUE RFP C 1120 source : AC3 12) chain C residue 394 type sequence F description BINDING SITE FOR RESIDUE RFP C 1120 source : AC3 13) chain C residue 396 type sequence D description BINDING SITE FOR RESIDUE RFP C 1120 source : AC3 14) chain C residue 405 type sequence R description BINDING SITE FOR RESIDUE RFP C 1120 source : AC3 15) chain C residue 406 type sequence H description BINDING SITE FOR RESIDUE RFP C 1120 source : AC3 16) chain C residue 409 type sequence R description BINDING SITE FOR RESIDUE RFP C 1120 source : AC3 17) chain C residue 411 type sequence S description BINDING SITE FOR RESIDUE RFP C 1120 source : AC3 18) chain C residue 452 type sequence I description BINDING SITE FOR RESIDUE RFP C 1120 source : AC3 19) chain C residue 836-848 type prosite sequence GDKLANRHGNKGV description RNA_POL_BETA RNA polymerases beta chain signature. GdKLANrHGNKGV source prosite : PS01166 20) chain D residue 58 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 21) chain D residue 1201 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 22) chain D residue 1204 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 23) chain D residue 60 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 24) chain D residue 73 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 25) chain D residue 76 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 26) chain D residue 739 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 27) chain D residue 741 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 28) chain D residue 743 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 29) chain D residue 1112 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 30) chain D residue 1194 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1

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