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eF-site ID
|
1ygr-B |
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PDB Code
|
1ygr |
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Chain
|
B |
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click to enlarge
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Title
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Crystal structure of the tandem phosphatase domain of RPTP CD45 |
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Classification
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HYDROLASE |
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Compound
|
CD45 Protein Tyrosine Phosphatase |
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Source
|
Homo sapiens (Human) (CD3Z_HUMAN) |
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Sequence
|
B: |
KQLXNVEPIHADILLETYKRKIADEGRPFLAEFQSIPRVF
SKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAG
SNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRXIWEQK
ATVIVXVTRCEEGNRNKCAEYWPSXEEGTRAFGDVVVKIN
QHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGV
PEDPHLLLKLRRRVNAFSNFFSGPIVVHSSAGVGRTGTYI
GIDAXLEGLEAENKVDVYGYVVKLRRQRCLXVQVEAQYIL
IHQALVEYNQFGETEVNLSELHPYLHNXKKRDPPSEPSPL
EAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNR
VPLKHESKYINASFIXSYWKPEVXIAAQGPLKETIGDFWQ
XIFQRKVKVIVXLTELKHGDQEICAQYWGEGKQTYGDIEV
DLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVE
QLPAEPKELISXIQVVKQKLPKSTPLLIHCRDGSQQTGIF
CALLNLLESAETEEVVDIFQVVKALRKARLGXVSTFEQYQ
FLYDVIASTYPAQN
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Description
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Functional site
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|
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1)
|
chain |
B |
| residue |
1146 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
Phosphocysteine intermediate => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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2)
|
chain |
B |
| residue |
952 |
| type |
MOD_RES |
| sequence |
V
|
| description |
Phosphoserine => ECO:0007744|PubMed:19367720, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
3)
|
chain |
B |
| residue |
798 |
| type |
BINDING |
| sequence |
G
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
4)
|
chain |
B |
| residue |
830 |
| type |
BINDING |
| sequence |
A
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
5)
|
chain |
B |
| residue |
874 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
6)
|
chain |
B |
| residue |
660 |
| type |
MOD_RES |
| sequence |
D
|
| description |
Phosphotyrosine => ECO:0000250|UniProtKB:P04157
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
|