eF-site ID 1ycp-M PDB Code 1ycp Chain M click to enlarge Title THE CRYSTAL STRUCTURE OF FIBRINOGEN-AA PEPTIDE 1-23 (F8Y) BOUND TO BOVINE THROMBIN EXPLAINS WHY THE MUTATION OF PHE-8 TO TYROSINE STRONGLY INHIBITS NORMAL CLEAVAGE AT ARGININE-16 Classification HYDROLASE/HYDROLASE SUBSTRATE Compound EPSILON THROMBIN Source ORGANISM_COMMON: cattle; ORGANISM_SCIENTIFIC: Bos taurus; Sequence M:  VQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGE GKRGDACEGDSGGPFVMKSPYNNRWYQMGIVSWGEGCDRD GKYGFYTHVFRLKKWIQKVID Description Functional site 1) chain M residue 174 type sequence I description BINDING SITE FOR CHAIN N OF FIBRINOPEPTIDE A-ALPHA source : AC2 2) chain M residue 189 type sequence D description BINDING SITE FOR CHAIN N OF FIBRINOPEPTIDE A-ALPHA source : AC2 3) chain M residue 192 type sequence E description BINDING SITE FOR CHAIN N OF FIBRINOPEPTIDE A-ALPHA source : AC2 4) chain M residue 193 type sequence G description BINDING SITE FOR CHAIN N OF FIBRINOPEPTIDE A-ALPHA source : AC2 5) chain M residue 195 type sequence S description BINDING SITE FOR CHAIN N OF FIBRINOPEPTIDE A-ALPHA source : AC2 6) chain M residue 214 type sequence S description BINDING SITE FOR CHAIN N OF FIBRINOPEPTIDE A-ALPHA source : AC2 7) chain M residue 215 type sequence W description BINDING SITE FOR CHAIN N OF FIBRINOPEPTIDE A-ALPHA source : AC2 8) chain M residue 216 type sequence G description BINDING SITE FOR CHAIN N OF FIBRINOPEPTIDE A-ALPHA source : AC2 9) chain M residue 219 type sequence G description BINDING SITE FOR CHAIN N OF FIBRINOPEPTIDE A-ALPHA source : AC2 10) chain M residue 189-200 type prosite sequence DACEGDSGGPFV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV source prosite : PS00135

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