eF-site ID 1ycp-H PDB Code 1ycp Chain H click to enlarge Title THE CRYSTAL STRUCTURE OF FIBRINOGEN-AA PEPTIDE 1-23 (F8Y) BOUND TO BOVINE THROMBIN EXPLAINS WHY THE MUTATION OF PHE-8 TO TYROSINE STRONGLY INHIBITS NORMAL CLEAVAGE AT ARGININE-16 Classification HYDROLASE/HYDROLASE SUBSTRATE Compound EPSILON THROMBIN Source ORGANISM_COMMON: cattle; ORGANISM_SCIENTIFIC: Bos taurus; Sequence H:  IVEGQDAEVGLSPWQVMLFRKSPQELLCGASLISDRWVLT AAHCLLYPPWDKNFTVDDLLVRIGKHSRTRYERKVEKISM LDKIYIHPRYNWKENLDRDIALLKLKRPIELSDYIHPVCL PDKQTAAKLLHAGFKGRVTGWGNRREVQPSVLQVVNLPLV ERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGDSGGP FVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKK WIQKVID Description Functional site 1) chain H residue 41 type sequence L description BINDING SITE FOR CHAIN F OF FIBRINOPEPTIDE A-ALPHA source : AC1 2) chain H residue 57 type sequence H description BINDING SITE FOR CHAIN F OF FIBRINOPEPTIDE A-ALPHA source : AC1 3) chain H residue 60 type sequence L description BINDING SITE FOR CHAIN F OF FIBRINOPEPTIDE A-ALPHA source : AC1 4) chain H residue 96 type sequence W description BINDING SITE FOR CHAIN F OF FIBRINOPEPTIDE A-ALPHA source : AC1 5) chain H residue 97 type sequence K description BINDING SITE FOR CHAIN F OF FIBRINOPEPTIDE A-ALPHA source : AC1 6) chain H residue 97 type sequence K description BINDING SITE FOR CHAIN F OF FIBRINOPEPTIDE A-ALPHA source : AC1 7) chain H residue 99 type sequence L description BINDING SITE FOR CHAIN F OF FIBRINOPEPTIDE A-ALPHA source : AC1 8) chain H residue 174 type sequence I description BINDING SITE FOR CHAIN F OF FIBRINOPEPTIDE A-ALPHA source : AC1 9) chain H residue 189 type sequence D description BINDING SITE FOR CHAIN F OF FIBRINOPEPTIDE A-ALPHA source : AC1 10) chain H residue 190 type sequence A description BINDING SITE FOR CHAIN F OF FIBRINOPEPTIDE A-ALPHA source : AC1 11) chain H residue 191 type sequence C description BINDING SITE FOR CHAIN F OF FIBRINOPEPTIDE A-ALPHA source : AC1 12) chain H residue 192 type sequence E description BINDING SITE FOR CHAIN F OF FIBRINOPEPTIDE A-ALPHA source : AC1 13) chain H residue 193 type sequence G description BINDING SITE FOR CHAIN F OF FIBRINOPEPTIDE A-ALPHA source : AC1 14) chain H residue 195 type sequence S description BINDING SITE FOR CHAIN F OF FIBRINOPEPTIDE A-ALPHA source : AC1 15) chain H residue 214 type sequence S description BINDING SITE FOR CHAIN F OF FIBRINOPEPTIDE A-ALPHA source : AC1 16) chain H residue 215 type sequence W description BINDING SITE FOR CHAIN F OF FIBRINOPEPTIDE A-ALPHA source : AC1 17) chain H residue 216 type sequence G description BINDING SITE FOR CHAIN F OF FIBRINOPEPTIDE A-ALPHA source : AC1 18) chain H residue 219 type sequence G description BINDING SITE FOR CHAIN F OF FIBRINOPEPTIDE A-ALPHA source : AC1 19) chain H residue 60 type sequence L description BINDING SITE FOR CHAIN N OF FIBRINOPEPTIDE A-ALPHA source : AC2 20) chain H residue 195 type SITE sequence S description Cleavage; by thrombin; to release fibrinopeptide A source Swiss-Prot : SWS_FT_FI1 21) chain H residue 189-200 type prosite sequence DACEGDSGGPFV description TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV source prosite : PS00135 22) chain H residue 53-58 type prosite sequence LTAAHC description TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC source prosite : PS00134

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