eF-site ID 1yc3-A PDB Code 1yc3 Chain A click to enlarge Title Crystal Structure of human HSP90alpha complexed with dihydroxyphenylpyrazoles Classification CELL CYCLE Compound Heat shock protein HSP 90-alpha Source Homo sapiens (Human) (HS90A_HUMAN) Sequence A:  QPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELI SNSSDALDKIRYETLTDPSKLDSGKELHINLIPNKQDRTL TIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADIS MIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGS FTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKK HSQFIGYPITLFVE Description Functional site 1) chain A residue 51 type sequence N description BINDING SITE FOR RESIDUE 4BC A 237 source : AC1 2) chain A residue 55 type sequence A description BINDING SITE FOR RESIDUE 4BC A 237 source : AC1 3) chain A residue 58 type sequence K description BINDING SITE FOR RESIDUE 4BC A 237 source : AC1 4) chain A residue 93 type sequence D description BINDING SITE FOR RESIDUE 4BC A 237 source : AC1 5) chain A residue 96 type sequence I description BINDING SITE FOR RESIDUE 4BC A 237 source : AC1 6) chain A residue 97 type sequence G description BINDING SITE FOR RESIDUE 4BC A 237 source : AC1 7) chain A residue 98 type sequence M description BINDING SITE FOR RESIDUE 4BC A 237 source : AC1 8) chain A residue 138 type sequence F description BINDING SITE FOR RESIDUE 4BC A 237 source : AC1 9) chain A residue 184 type sequence T description BINDING SITE FOR RESIDUE 4BC A 237 source : AC1 10) chain A residue 186 type sequence V description BINDING SITE FOR RESIDUE 4BC A 237 source : AC1 11) chain A residue 52 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI1 12) chain A residue 94 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI1 13) chain A residue 139 type BINDING sequence Y description source Swiss-Prot : SWS_FT_FI1 14) chain A residue 113 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 15) chain A residue 59 type MOD_RES sequence I description N6-acetyllysine => ECO:0000250|UniProtKB:P07901 source Swiss-Prot : SWS_FT_FI3 16) chain A residue 85 type MOD_RES sequence Q description N6-acetyllysine => ECO:0000250|UniProtKB:P07901 source Swiss-Prot : SWS_FT_FI3 17) chain A residue 38-47 type prosite sequence YSNKEIFLRE description HSP90 Heat shock hsp90 proteins family signature. YsNKEIFLRE source prosite : PS00298

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