eF-site ID 1yb5-AB PDB Code 1yb5 Chain A, B click to enlarge Title Crystal structure of human Zeta-Crystallin with bound NADP Classification OXIDOREDUCTASE Compound Quinone oxidoreductase Source Homo sapiens (Human) (QOR_HUMAN) Sequence A:  KLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHAC GVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNAS AFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQ GAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAA CQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNY IDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIV VGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAA LQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKM ILLL B:  KLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHAC GVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNAS AFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQ GAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAA CQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNY IDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIV VGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAA LQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKM ILLL Description Functional site 1) chain A residue 50 type sequence V description BINDING SITE FOR RESIDUE ACT B 811 source : AC1 2) chain A residue 53 type sequence Y description BINDING SITE FOR RESIDUE ACT B 811 source : AC1 3) chain A residue 59 type sequence Y description BINDING SITE FOR RESIDUE ACT B 811 source : AC1 4) chain B residue 257 type sequence R description BINDING SITE FOR RESIDUE ACT B 811 source : AC1 5) chain B residue 260 type sequence M description BINDING SITE FOR RESIDUE ACT B 811 source : AC1 6) chain A residue 257 type sequence R description BINDING SITE FOR RESIDUE ACT A 812 source : AC2 7) chain A residue 260 type sequence M description BINDING SITE FOR RESIDUE ACT A 812 source : AC2 8) chain B residue 50 type sequence V description BINDING SITE FOR RESIDUE ACT A 812 source : AC2 9) chain B residue 53 type sequence Y description BINDING SITE FOR RESIDUE ACT A 812 source : AC2 10) chain B residue 59 type sequence Y description BINDING SITE FOR RESIDUE ACT A 812 source : AC2 11) chain A residue 80 type sequence V description BINDING SITE FOR RESIDUE ACT A 813 source : AC3 12) chain A residue 82 type sequence D description BINDING SITE FOR RESIDUE ACT A 813 source : AC3 13) chain B residue 80 type sequence V description BINDING SITE FOR RESIDUE ACT A 813 source : AC3 14) chain B residue 81 type sequence G description BINDING SITE FOR RESIDUE ACT A 813 source : AC3 15) chain B residue 82 type sequence D description BINDING SITE FOR RESIDUE ACT A 813 source : AC3 16) chain A residue 156 type sequence G description BINDING SITE FOR RESIDUE CL A 816 source : AC4 17) chain A residue 159 type sequence G description BINDING SITE FOR RESIDUE CL A 816 source : AC4 18) chain A residue 160 type sequence G description BINDING SITE FOR RESIDUE CL A 816 source : AC4 19) chain A residue 162 type sequence G description BINDING SITE FOR RESIDUE CL A 816 source : AC4 20) chain B residue 156 type sequence G description BINDING SITE FOR RESIDUE CL B 817 source : AC5 21) chain B residue 159 type sequence G description BINDING SITE FOR RESIDUE CL B 817 source : AC5 22) chain B residue 160 type sequence G description BINDING SITE FOR RESIDUE CL B 817 source : AC5 23) chain B residue 162 type sequence G description BINDING SITE FOR RESIDUE CL B 817 source : AC5 24) chain A residue 97 type sequence S description BINDING SITE FOR RESIDUE CL A 818 source : AC6 25) chain A residue 98 type sequence T description BINDING SITE FOR RESIDUE CL A 818 source : AC6 26) chain A residue 109 type sequence A description BINDING SITE FOR RESIDUE CL A 818 source : AC6 27) chain A residue 110 type sequence A description BINDING SITE FOR RESIDUE CL A 818 source : AC6 28) chain A residue 113 type sequence T description BINDING SITE FOR RESIDUE CL A 818 source : AC6 29) chain B residue 51 type sequence E description BINDING SITE FOR RESIDUE CL B 819 source : AC7 30) chain B residue 69 type sequence P description BINDING SITE FOR RESIDUE CL B 819 source : AC7 31) chain B residue 70 type sequence G description BINDING SITE FOR RESIDUE CL B 819 source : AC7 32) chain A residue 49 type sequence P description BINDING SITE FOR RESIDUE NAP A 801 source : AC8 33) chain A residue 53 type sequence Y description BINDING SITE FOR RESIDUE NAP A 801 source : AC8 34) chain A residue 131 type sequence I description BINDING SITE FOR RESIDUE NAP A 801 source : AC8 35) chain A residue 135 type sequence T description BINDING SITE FOR RESIDUE NAP A 801 source : AC8 36) chain A residue 155 type sequence H description BINDING SITE FOR RESIDUE NAP A 801 source : AC8 37) chain A residue 156 type sequence G description BINDING SITE FOR RESIDUE NAP A 801 source : AC8 38) chain A residue 158 type sequence S description BINDING SITE FOR RESIDUE NAP A 801 source : AC8 39) chain A residue 159 type sequence G description BINDING SITE FOR RESIDUE NAP A 801 source : AC8 40) chain A residue 160 type sequence G description BINDING SITE FOR RESIDUE NAP A 801 source : AC8 41) chain A residue 161 type sequence V description BINDING SITE FOR RESIDUE NAP A 801 source : AC8 42) chain A residue 180 type sequence A description BINDING SITE FOR RESIDUE NAP A 801 source : AC8 43) chain A residue 181 type sequence G description BINDING SITE FOR RESIDUE NAP A 801 source : AC8 44) chain A residue 200 type sequence H description BINDING SITE FOR RESIDUE NAP A 801 source : AC8 45) chain A residue 225 type sequence L description BINDING SITE FOR RESIDUE NAP A 801 source : AC8 46) chain A residue 229 type sequence N description BINDING SITE FOR RESIDUE NAP A 801 source : AC8 47) chain A residue 246 type sequence V description BINDING SITE FOR RESIDUE NAP A 801 source : AC8 48) chain A residue 249 type sequence R description BINDING SITE FOR RESIDUE NAP A 801 source : AC8 49) chain A residue 269 type sequence V description BINDING SITE FOR RESIDUE NAP A 801 source : AC8 50) chain A residue 270 type sequence T description BINDING SITE FOR RESIDUE NAP A 801 source : AC8 51) chain A residue 271 type sequence L description BINDING SITE FOR RESIDUE NAP A 801 source : AC8 52) chain A residue 315 type sequence I description BINDING SITE FOR RESIDUE NAP A 801 source : AC8 53) chain A residue 320 type sequence G description BINDING SITE FOR RESIDUE NAP A 801 source : AC8 54) chain A residue 321 type sequence A description BINDING SITE FOR RESIDUE NAP A 801 source : AC8 55) chain B residue 49 type sequence P description BINDING SITE FOR RESIDUE NAP B 802 source : AC9 56) chain B residue 53 type sequence Y description BINDING SITE FOR RESIDUE NAP B 802 source : AC9 57) chain B residue 131 type sequence I description BINDING SITE FOR RESIDUE NAP B 802 source : AC9 58) chain B residue 135 type sequence T description BINDING SITE FOR RESIDUE NAP B 802 source : AC9 59) chain B residue 155 type sequence H description BINDING SITE FOR RESIDUE NAP B 802 source : AC9 60) chain B residue 156 type sequence G description BINDING SITE FOR RESIDUE NAP B 802 source : AC9 61) chain B residue 158 type sequence S description BINDING SITE FOR RESIDUE NAP B 802 source : AC9 62) chain B residue 159 type sequence G description BINDING SITE FOR RESIDUE NAP B 802 source : AC9 63) chain B residue 160 type sequence G description BINDING SITE FOR RESIDUE NAP B 802 source : AC9 64) chain B residue 161 type sequence V description BINDING SITE FOR RESIDUE NAP B 802 source : AC9 65) chain B residue 180 type sequence A description BINDING SITE FOR RESIDUE NAP B 802 source : AC9 66) chain B residue 181 type sequence G description BINDING SITE FOR RESIDUE NAP B 802 source : AC9 67) chain B residue 200 type sequence H description BINDING SITE FOR RESIDUE NAP B 802 source : AC9 68) chain B residue 225 type sequence L description BINDING SITE FOR RESIDUE NAP B 802 source : AC9 69) chain B residue 229 type sequence N description BINDING SITE FOR RESIDUE NAP B 802 source : AC9 70) chain B residue 246 type sequence V description BINDING SITE FOR RESIDUE NAP B 802 source : AC9 71) chain B residue 247 type sequence G description BINDING SITE FOR RESIDUE NAP B 802 source : AC9 72) chain B residue 249 type sequence R description BINDING SITE FOR RESIDUE NAP B 802 source : AC9 73) chain B residue 269 type sequence V description BINDING SITE FOR RESIDUE NAP B 802 source : AC9 74) chain B residue 270 type sequence T description BINDING SITE FOR RESIDUE NAP B 802 source : AC9 75) chain B residue 271 type sequence L description BINDING SITE FOR RESIDUE NAP B 802 source : AC9 76) chain B residue 315 type sequence I description BINDING SITE FOR RESIDUE NAP B 802 source : AC9 77) chain B residue 320 type sequence G description BINDING SITE FOR RESIDUE NAP B 802 source : AC9 78) chain B residue 321 type sequence A description BINDING SITE FOR RESIDUE NAP B 802 source : AC9 79) chain A residue 171 type sequence A description BINDING SITE FOR RESIDUE GOL A 814 source : BC1 80) chain A residue 172 type sequence Y description BINDING SITE FOR RESIDUE GOL A 814 source : BC1 81) chain A residue 292 type sequence I description BINDING SITE FOR RESIDUE GOL A 814 source : BC1 82) chain A residue 294 type sequence W description BINDING SITE FOR RESIDUE GOL A 814 source : BC1 83) chain B residue 171 type sequence A description BINDING SITE FOR RESIDUE GOL A 814 source : BC1 84) chain B residue 172 type sequence Y description BINDING SITE FOR RESIDUE GOL A 814 source : BC1 85) chain B residue 294 type sequence W description BINDING SITE FOR RESIDUE GOL A 814 source : BC1 86) chain A residue 82 type sequence D description BINDING SITE FOR RESIDUE GOL A 815 source : BC2 87) chain A residue 83 type sequence N description BINDING SITE FOR RESIDUE GOL A 815 source : BC2 88) chain A residue 85 type sequence S description BINDING SITE FOR RESIDUE GOL A 815 source : BC2 89) chain B residue 34 type sequence K description BINDING SITE FOR RESIDUE GOL A 815 source : BC2 90) chain A residue 301 type sequence S description BINDING SITE FOR RESIDUE GOL A 820 source : BC3 91) chain A residue 303 type sequence Y description BINDING SITE FOR RESIDUE GOL A 820 source : BC3 92) chain A residue 314 type sequence N description BINDING SITE FOR RESIDUE GOL A 820 source : BC3 93) chain A residue 319 type sequence S description BINDING SITE FOR RESIDUE GOL A 820 source : BC3 94) chain A residue 320 type sequence G description BINDING SITE FOR RESIDUE GOL A 820 source : BC3 95) chain A residue 325 type sequence M description BINDING SITE FOR RESIDUE GOL A 820 source : BC3 96) chain B residue 301 type sequence S description BINDING SITE FOR RESIDUE GOL B 821 source : BC4 97) chain B residue 303 type sequence Y description BINDING SITE FOR RESIDUE GOL B 821 source : BC4 98) chain B residue 314 type sequence N description BINDING SITE FOR RESIDUE GOL B 821 source : BC4 99) chain B residue 318 type sequence G description BINDING SITE FOR RESIDUE GOL B 821 source : BC4 100) chain B residue 319 type sequence S description BINDING SITE FOR RESIDUE GOL B 821 source : BC4 101) chain B residue 320 type sequence G description BINDING SITE FOR RESIDUE GOL B 821 source : BC4 102) chain B residue 325 type sequence M description BINDING SITE FOR RESIDUE GOL B 821 source : BC4 103) chain A residue 149-170 type prosite sequence GESVLVHGASGGVGLAACQIAR description QOR_ZETA_CRYSTAL Quinone oxidoreductase / zeta-crystallin signature. GEsvLvhgASGGvGlaacQiaR source prosite : PS01162 104) chain A residue 53 type BINDING sequence Y description BINDING => ECO:0000269|Ref.17 source Swiss-Prot : SWS_FT_FI1 105) chain B residue 181 type BINDING sequence G description BINDING => ECO:0000269|Ref.17 source Swiss-Prot : SWS_FT_FI1 106) chain B residue 200 type BINDING sequence H description BINDING => ECO:0000269|Ref.17 source Swiss-Prot : SWS_FT_FI1 107) chain B residue 229 type BINDING sequence N description BINDING => ECO:0000269|Ref.17 source Swiss-Prot : SWS_FT_FI1 108) chain B residue 246 type BINDING sequence V description BINDING => ECO:0000269|Ref.17 source Swiss-Prot : SWS_FT_FI1 109) chain B residue 269 type BINDING sequence V description BINDING => ECO:0000269|Ref.17 source Swiss-Prot : SWS_FT_FI1 110) chain A residue 158 type BINDING sequence S description BINDING => ECO:0000269|Ref.17 source Swiss-Prot : SWS_FT_FI1 111) chain A residue 181 type BINDING sequence G description BINDING => ECO:0000269|Ref.17 source Swiss-Prot : SWS_FT_FI1 112) chain A residue 200 type BINDING sequence H description BINDING => ECO:0000269|Ref.17 source Swiss-Prot : SWS_FT_FI1 113) chain A residue 229 type BINDING sequence N description BINDING => ECO:0000269|Ref.17 source Swiss-Prot : SWS_FT_FI1 114) chain A residue 246 type BINDING sequence V description BINDING => ECO:0000269|Ref.17 source Swiss-Prot : SWS_FT_FI1 115) chain A residue 269 type BINDING sequence V description BINDING => ECO:0000269|Ref.17 source Swiss-Prot : SWS_FT_FI1 116) chain B residue 53 type BINDING sequence Y description BINDING => ECO:0000269|Ref.17 source Swiss-Prot : SWS_FT_FI1 117) chain B residue 158 type BINDING sequence S description BINDING => ECO:0000269|Ref.17 source Swiss-Prot : SWS_FT_FI1 118) chain A residue 23 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3 119) chain B residue 23 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3 120) chain A residue 248 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:21406692 source Swiss-Prot : SWS_FT_FI4 121) chain B residue 248 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:21406692 source Swiss-Prot : SWS_FT_FI4 122) chain A residue 296 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:P47199 source Swiss-Prot : SWS_FT_FI5 123) chain B residue 296 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:P47199 source Swiss-Prot : SWS_FT_FI5

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