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eF-site ID
|
1yah-C |
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PDB Code
|
1yah |
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Chain
|
C |
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click to enlarge
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Title
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Crystal Structure of Human Liver Carboxylesterase complexed to Etyl Acetate; A Fatty Acid Ethyl Ester Analogue |
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Classification
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HYDROLASE |
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Compound
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CES1 protein |
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Source
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(EST1_HUMAN) |
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Sequence
|
C: |
SSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPL
GPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSEL
FTNRKENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIH
GGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFST
GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGE
SAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGD
VKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLK
MKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERN
FHTVPYMVGINKQEFGWLIPMLMSYPLSEGQLDQKTAMSL
LWKSYPLVCIAKELIPEATEKYLGGTDDTVKKKDLFLDLI
ADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKP
KTVIGDHGDELFSVFGAPFLKEGASEEEIRLSKMVMKFWA
NFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKLKD
KEVAFWTNLFAK
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Description
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Functional site
|
|
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1)
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chain |
C |
| residue |
221 |
| type |
ACT_SITE |
| sequence |
S
|
| description |
Acyl-ester intermediate => ECO:0000255|PROSITE-ProRule:PRU10039, ECO:0000269|PubMed:12022871
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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2)
|
chain |
C |
| residue |
354 |
| type |
ACT_SITE |
| sequence |
E
|
| description |
Charge relay system => ECO:0000269|PubMed:12022871
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
3)
|
chain |
C |
| residue |
469 |
| type |
ACT_SITE |
| sequence |
G
|
| description |
Charge relay system => ECO:0000269|PubMed:12022871
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
C |
| residue |
381 |
| type |
MOD_RES |
| sequence |
L
|
| description |
Phosphoserine => ECO:0007744|PubMed:24275569
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
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5)
|
chain |
C |
| residue |
79 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12022871
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
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