|
eF-site ID
|
1yah-B |
PDB Code
|
1yah |
Chain
|
B |
|
click to enlarge
|
|
Title
|
Crystal Structure of Human Liver Carboxylesterase complexed to Etyl Acetate; A Fatty Acid Ethyl Ester Analogue |
Classification
|
HYDROLASE |
Compound
|
CES1 protein |
Source
|
(EST1_HUMAN) |
|
Sequence
|
B: |
SSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPL
GPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSEL
FTNRKENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIH
GGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFST
GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGE
SAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGD
VKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLK
MKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERN
FHTVPYMVGINKQEFGWLIPMLMSYPLSEGQLDQKTAMSL
LWKSYPLVCIAKELIPEATEKYLGGTDDTVKKKDLFLDLI
ADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKP
KTVIGDHGDELFSVFGAPFLKEGASEEEIRLSKMVMKFWA
NFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKLKD
KEVAFWTNLFAK
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
B |
residue |
221 |
type |
ACT_SITE |
sequence |
S
|
description |
Acyl-ester intermediate => ECO:0000255|PROSITE-ProRule:PRU10039, ECO:0000269|PubMed:12022871
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
2)
|
chain |
B |
residue |
354 |
type |
ACT_SITE |
sequence |
E
|
description |
Charge relay system => ECO:0000269|PubMed:12022871
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
3)
|
chain |
B |
residue |
469 |
type |
ACT_SITE |
sequence |
G
|
description |
Charge relay system => ECO:0000269|PubMed:12022871
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
4)
|
chain |
B |
residue |
381 |
type |
MOD_RES |
sequence |
L
|
description |
Phosphoserine => ECO:0007744|PubMed:24275569
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
5)
|
chain |
B |
residue |
79 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12022871
|
source |
Swiss-Prot : SWS_FT_FI4
|
|
|
|