eF-site ID 1y8x-A
PDB Code 1y8x
Chain A

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Title Structural basis for recruitment of Ubc12 by an E2-binding domain in NEDD8's E1
Classification LIGASE
Compound Ubiquitin-conjugating enzyme E2 M
Source Homo sapiens (Human) (UBA3_HUMAN)
Sequence A:  GSXASAAQLRIQKDINELNLPKTCDISFSDPDDLLNFKLV
ICPDEGFYKSGKFVFSFKVGQGYPHDPPKVKCETXVYHPN
IDLEGNVCLNILREDWKPVLTINSIIYGLQYLFLEPNPED
PLNKEAAEVLQNNRRLFEQNVQRSXRGGYIGSTYFERCLK
Description


Functional site

1) chain A
residue 111
type ACT_SITE
sequence C
description Glycyl thioester intermediate => ECO:0000255|PROSITE-ProRule:PRU00388
source Swiss-Prot : SWS_FT_FI1

2) chain A
residue 50
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:18669648
source Swiss-Prot : SWS_FT_FI2

3) chain A
residue 169
type MOD_RES
sequence R
description Omega-N-methylarginine; alternate => ECO:0007744|PubMed:24129315
source Swiss-Prot : SWS_FT_FI3

4) chain A
residue 100-115
type prosite
sequence YHPNIDLEGNVCLNIL
description UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNIdle.GnVCLniL
source prosite : PS00183


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