|
|
eF-site ID
|
1y8n-AB |
|
PDB Code
|
1y8n |
|
Chain
|
A, B |
|
click to enlarge
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Title
|
Crystal structure of the PDK3-L2 complex |
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Classification
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TRANSFERASE |
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Compound
|
[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3 |
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Source
|
Homo sapiens (Human) (ODP2_HUMAN) |
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Sequence
|
A: |
PKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKE
LPVRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELL
EYENKSPEDPQVLDNFLQVLIKVRNRHNDVVPTMAQGVIE
YKEKFGFDPFISTNIQYFLDRFYTNRISFRMLINQHTLLF
GGDTNPVHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYY
LVAPELEVEEFNAKAPDKPIQVVYVPSHLFHMLFELFKNS
MRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGV
PLRKIDRLFNYMYSPLFGYGLPISRLYARYFQGDLKLYSM
EGVGTDAVIYLKALSSESFERLPVFNKSAWRHYKTTPEAD
DWSNPSSEPRDASK
|
| B: |
SYPPHMQVLLPALSPTMTMGTVQRWEKKVGEKLSEGDLLA
EIETDKATIGFEVQEEGYLAKILVPEGTRDVPLGTPLCII
VEKEADISAFADYTDLK
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Description
|
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Functional site
|
|
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1)
|
chain |
A |
| residue |
20 |
| type |
|
| sequence |
S
|
| description |
BINDING SITE FOR RESIDUE K A 501
|
| source |
: AC1
|
|
|
2)
|
chain |
A |
| residue |
21 |
| type |
|
| sequence |
R
|
| description |
BINDING SITE FOR RESIDUE K A 501
|
| source |
: AC1
|
|
|
3)
|
chain |
A |
| residue |
22 |
| type |
|
| sequence |
F
|
| description |
BINDING SITE FOR RESIDUE K A 501
|
| source |
: AC1
|
|
|
4)
|
chain |
A |
| residue |
59 |
| type |
|
| sequence |
N
|
| description |
BINDING SITE FOR RESIDUE K A 501
|
| source |
: AC1
|
|
|
5)
|
chain |
A |
| residue |
372 |
| type |
|
| sequence |
F
|
| description |
BINDING SITE FOR RESIDUE K A 501
|
| source |
: AC1
|
|
|
6)
|
chain |
A |
| residue |
48 |
| type |
|
| sequence |
F
|
| description |
BINDING SITE FOR RESIDUE RED B 373
|
| source |
: AC2
|
|
|
7)
|
chain |
B |
| residue |
173 |
| type |
|
| sequence |
K
|
| description |
BINDING SITE FOR RESIDUE RED B 373
|
| source |
: AC2
|
|
|
8)
|
chain |
A |
| residue |
278 |
| type |
MOD_RES |
| sequence |
K
|
| description |
N6-succinyllysine => ECO:0000250|UniProtKB:Q922H2
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
9)
|
chain |
B |
| residue |
138-149 |
| type |
prosite |
| sequence |
PALSPTMTMGTV
|
| description |
AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PalSPtMTMGTV
|
| source |
prosite : PS00178
|
|
|
10)
|
chain |
B |
| residue |
157-186 |
| type |
prosite |
| sequence |
GEKLSEGDLLAEIETDKATIGFEVQEEGYL
|
| description |
LIPOYL 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. GekLsegDLLaeIETdKATigFevqeeGyL
|
| source |
prosite : PS00189
|
|
|
11)
|
chain |
B |
| residue |
206 |
| type |
MOD_RES |
| sequence |
I
|
| description |
N6-lipoyllysine => ECO:0000255|PROSITE-ProRule:PRU01066, ECO:0000269|PubMed:15861126, ECO:0000269|PubMed:17532006, ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:25525879, ECO:0007744|PDB:1Y8N, ECO:0007744|PDB:1Y8O, ECO:0007744|PDB:1Y8P, ECO:0007744|PDB:2PNR, ECO:0007744|PDB:2Q8I
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
12)
|
chain |
A |
| residue |
287 |
| type |
MOD_RES |
| sequence |
D
|
| description |
N6-lipoyllysine => ECO:0000255|PROSITE-ProRule:PRU01066, ECO:0000269|PubMed:15861126, ECO:0000269|PubMed:17532006, ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:25525879, ECO:0007744|PDB:1Y8N, ECO:0007744|PDB:1Y8O, ECO:0007744|PDB:1Y8P, ECO:0007744|PDB:2PNR, ECO:0007744|PDB:2Q8I
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
13)
|
chain |
A |
| residue |
306 |
| type |
MOD_RES |
| sequence |
S
|
| description |
N6-lipoyllysine => ECO:0000255|PROSITE-ProRule:PRU01066, ECO:0000269|PubMed:15861126, ECO:0000269|PubMed:17532006, ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:25525879, ECO:0007744|PDB:1Y8N, ECO:0007744|PDB:1Y8O, ECO:0007744|PDB:1Y8P, ECO:0007744|PDB:2PNR, ECO:0007744|PDB:2Q8I
|
| source |
Swiss-Prot : SWS_FT_FI1
|
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