eF-site ID 1y4g-B
PDB Code 1y4g
Chain B

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Title T-To-T(High) quaternary transitions in human hemoglobin: betaW37G deoxy low-salt (10 test sets)
Classification TRANSPORT PROTEIN
Compound Hemoglobin alpha chain
Source ORGANISM_COMMON: human; ORGANISM_SCIENTIFIC: Homo sapiens;
Sequence B:  MHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPGTQR
FFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDN
LKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGK
EFTPPVQAAYQKVVAGVANALAHKYH
Description


Functional site
1) chain B
residue 41
type
sequence F
description BINDING SITE FOR RESIDUE HEM B 147
source : AC2
2) chain B
residue 63
type
sequence H
description BINDING SITE FOR RESIDUE HEM B 147
source : AC2
3) chain B
residue 66
type
sequence K
description BINDING SITE FOR RESIDUE HEM B 147
source : AC2
4) chain B
residue 67
type
sequence V
description BINDING SITE FOR RESIDUE HEM B 147
source : AC2
5) chain B
residue 91
type
sequence L
description BINDING SITE FOR RESIDUE HEM B 147
source : AC2
6) chain B
residue 92
type
sequence H
description BINDING SITE FOR RESIDUE HEM B 147
source : AC2
7) chain B
residue 96
type
sequence L
description BINDING SITE FOR RESIDUE HEM B 147
source : AC2
8) chain B
residue 102
type
sequence N
description BINDING SITE FOR RESIDUE HEM B 147
source : AC2
9) chain B
residue 103
type
sequence F
description BINDING SITE FOR RESIDUE HEM B 147
source : AC2
10) chain B
residue 141
type
sequence L
description BINDING SITE FOR RESIDUE HEM B 147
source : AC2
11) chain B
residue 17
type
sequence K
description BINDING SITE FOR RESIDUE HEM C 142
source : AC3
12) chain B
residue 120
type
sequence K
description BINDING SITE FOR RESIDUE HEM C 142
source : AC3
13) chain B
residue 2
type CARBOHYD
sequence H
description N-linked (Glc) (glycation) valine; in Hb A1c => ECO:0000269|PubMed:635569
source Swiss-Prot : SWS_FT_FI12
14) chain B
residue 67
type CARBOHYD
sequence V
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI13
15) chain B
residue 121
type CARBOHYD
sequence E
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI13
16) chain B
residue 9
type CARBOHYD
sequence S
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI13
17) chain B
residue 18
type CARBOHYD
sequence V
description N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI13
18) chain B
residue 145
type CARBOHYD
sequence Y
description N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI14
19) chain B
residue 83
type BINDING
sequence G
description
source Swiss-Prot : SWS_FT_FI1
20) chain B
residue 144
type BINDING
sequence K
description
source Swiss-Prot : SWS_FT_FI1
21) chain B
residue 2
type BINDING
sequence H
description
source Swiss-Prot : SWS_FT_FI1
22) chain B
residue 3
type BINDING
sequence L
description
source Swiss-Prot : SWS_FT_FI1
23) chain B
residue 93
type BINDING
sequence C
description proximal binding residue
source Swiss-Prot : SWS_FT_FI3
24) chain B
residue 94
type MOD_RES
sequence D
description S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411
source Swiss-Prot : SWS_FT_FI10
25) chain B
residue 145
type MOD_RES
sequence Y
description N6-acetyllysine; alternate => ECO:0000269|PubMed:4531009
source Swiss-Prot : SWS_FT_FI11
26) chain B
residue 85
type SITE
sequence F
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
27) chain B
residue 93
type SITE
sequence C
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
28) chain B
residue 105
type SITE
sequence L
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
29) chain B
residue 111
type SITE
sequence V
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
30) chain B
residue 120
type SITE
sequence K
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
31) chain B
residue 123
type SITE
sequence T
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
32) chain B
residue 129
type SITE
sequence A
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
33) chain B
residue 141
type SITE
sequence L
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
34) chain B
residue 145
type SITE
sequence Y
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
35) chain B
residue 8
type SITE
sequence K
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
36) chain B
residue 75
type SITE
sequence L
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
37) chain B
residue 26
type SITE
sequence E
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
38) chain B
residue 30
type SITE
sequence R
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
39) chain B
residue 36
type SITE
sequence P
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
40) chain B
residue 38
type SITE
sequence T
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
41) chain B
residue 46
type SITE
sequence G
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
42) chain B
residue 53
type SITE
sequence A
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
43) chain B
residue 57
type SITE
sequence N
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
44) chain B
residue 72
type SITE
sequence S
description (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433
source Swiss-Prot : SWS_FT_FI4
45) chain B
residue 60
type SITE
sequence V
description Not glycated => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI5
46) chain B
residue 83
type SITE
sequence G
description Not glycated => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI5
47) chain B
residue 96
type SITE
sequence L
description Not glycated => ECO:0000269|PubMed:7358733
source Swiss-Prot : SWS_FT_FI5
48) chain B
residue 2
type MOD_RES
sequence H
description N-pyruvate 2-iminyl-valine; in Hb A1b
source Swiss-Prot : SWS_FT_FI6
49) chain B
residue 10
type MOD_RES
sequence A
description Phosphoserine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI7
50) chain B
residue 45
type MOD_RES
sequence F
description Phosphoserine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI7
51) chain B
residue 13
type MOD_RES
sequence A
description Phosphothreonine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI8
52) chain B
residue 51
type MOD_RES
sequence P
description Phosphothreonine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI8
53) chain B
residue 88
type MOD_RES
sequence L
description Phosphothreonine => ECO:0007744|PubMed:24275569
source Swiss-Prot : SWS_FT_FI8
54) chain B
residue 60
type MOD_RES
sequence V
description N6-acetyllysine => ECO:0000269|PubMed:4531009
source Swiss-Prot : SWS_FT_FI9
55) chain B
residue 83
type MOD_RES
sequence G
description N6-acetyllysine => ECO:0000269|PubMed:4531009
source Swiss-Prot : SWS_FT_FI9
56) chain B
residue 64
type BINDING
sequence G
description distal binding residue
source Swiss-Prot : SWS_FT_FI2

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