eF-site ID 1y3a-A PDB Code 1y3a Chain A click to enlarge Title Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange Classification SIGNALING PROTEIN Compound Guanine nucleotide-binding protein G(i), alpha-1 subunit Source (1Y3A) Sequence A:  VKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVV YSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAMT AELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLD RIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFD VGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVMNRMHES MKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTIC YPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCA TDTKNVQFVFDAVTDVIIK Description Functional site 1) chain A residue 42 type sequence G description BINDING SITE FOR RESIDUE GDP A 355 source : AC1 2) chain A residue 43 type sequence E description BINDING SITE FOR RESIDUE GDP A 355 source : AC1 3) chain A residue 44 type sequence S description BINDING SITE FOR RESIDUE GDP A 355 source : AC1 4) chain A residue 45 type sequence G description BINDING SITE FOR RESIDUE GDP A 355 source : AC1 5) chain A residue 46 type sequence K description BINDING SITE FOR RESIDUE GDP A 355 source : AC1 6) chain A residue 47 type sequence S description BINDING SITE FOR RESIDUE GDP A 355 source : AC1 7) chain A residue 48 type sequence T description BINDING SITE FOR RESIDUE GDP A 355 source : AC1 8) chain A residue 150 type sequence D description BINDING SITE FOR RESIDUE GDP A 355 source : AC1 9) chain A residue 175 type sequence L description BINDING SITE FOR RESIDUE GDP A 355 source : AC1 10) chain A residue 176 type sequence R description BINDING SITE FOR RESIDUE GDP A 355 source : AC1 11) chain A residue 178 type sequence R description BINDING SITE FOR RESIDUE GDP A 355 source : AC1 12) chain A residue 269 type sequence N description BINDING SITE FOR RESIDUE GDP A 355 source : AC1 13) chain A residue 270 type sequence K description BINDING SITE FOR RESIDUE GDP A 355 source : AC1 14) chain A residue 272 type sequence D description BINDING SITE FOR RESIDUE GDP A 355 source : AC1 15) chain A residue 273 type sequence L description BINDING SITE FOR RESIDUE GDP A 355 source : AC1 16) chain A residue 325 type sequence C description BINDING SITE FOR RESIDUE GDP A 355 source : AC1 17) chain A residue 326 type sequence A description BINDING SITE FOR RESIDUE GDP A 355 source : AC1 18) chain A residue 327 type sequence T description BINDING SITE FOR RESIDUE GDP A 355 source : AC1 19) chain A residue 152 type BINDING sequence A description BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:4G5Q source Swiss-Prot : SWS_FT_FI3 20) chain A residue 176 type BINDING sequence R description BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q source Swiss-Prot : SWS_FT_FI4 21) chain A residue 205 type MOD_RES sequence R description Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704 source Swiss-Prot : SWS_FT_FI8 22) chain A residue 44 type BINDING sequence S description BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q source Swiss-Prot : SWS_FT_FI1 23) chain A residue 270 type BINDING sequence K description BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q source Swiss-Prot : SWS_FT_FI1 24) chain A residue 48 type BINDING sequence T description BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 182 type BINDING sequence T description BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 179 type MOD_RES sequence V description ADP-ribosylarginine; by cholera toxin => ECO:0000250 source Swiss-Prot : SWS_FT_FI7 27) chain A residue 201 type BINDING sequence V description BINDING => ECO:0000269|PubMed:21115486 source Swiss-Prot : SWS_FT_FI5 28) chain A residue 327 type BINDING sequence T description BINDING => ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q source Swiss-Prot : SWS_FT_FI6

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