eF-site ID 1y3a-CDGH
PDB Code 1y3a
Chain C, D, G, H

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Title Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange
Classification SIGNALING PROTEIN
Compound Guanine nucleotide-binding protein G(i), alpha-1 subunit
Source (1Y3A)
Sequence C:  VKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVV
YSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAMT
AELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLD
RIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFD
VGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVMNRMHES
MKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKKSPLTIC
YPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCA
TDTKNVQFVFDAVTDVII
D:  VKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVV
YSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAMT
AELAGVIKRLWKDSGVQACFNRSREYQLNDSAAYYLNDLD
RIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDLHFKMFD
VGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEM
NRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEKIKK
SPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIY
THFTCATDTKNVQFVFDAVTDVII
G:  SRVTWYDFLMED
H:  SRVTWYDFLMED
Description


Functional site
1) chain C
residue 42
type
sequence G
description BINDING SITE FOR RESIDUE GDP C 357
source : AC3
2) chain C
residue 43
type
sequence E
description BINDING SITE FOR RESIDUE GDP C 357
source : AC3
3) chain C
residue 44
type
sequence S
description BINDING SITE FOR RESIDUE GDP C 357
source : AC3
4) chain C
residue 45
type
sequence G
description BINDING SITE FOR RESIDUE GDP C 357
source : AC3
5) chain C
residue 46
type
sequence K
description BINDING SITE FOR RESIDUE GDP C 357
source : AC3
6) chain C
residue 47
type
sequence S
description BINDING SITE FOR RESIDUE GDP C 357
source : AC3
7) chain C
residue 48
type
sequence T
description BINDING SITE FOR RESIDUE GDP C 357
source : AC3
8) chain C
residue 150
type
sequence D
description BINDING SITE FOR RESIDUE GDP C 357
source : AC3
9) chain C
residue 175
type
sequence L
description BINDING SITE FOR RESIDUE GDP C 357
source : AC3
10) chain C
residue 176
type
sequence R
description BINDING SITE FOR RESIDUE GDP C 357
source : AC3
11) chain C
residue 177
type
sequence T
description BINDING SITE FOR RESIDUE GDP C 357
source : AC3
12) chain C
residue 178
type
sequence R
description BINDING SITE FOR RESIDUE GDP C 357
source : AC3
13) chain C
residue 269
type
sequence N
description BINDING SITE FOR RESIDUE GDP C 357
source : AC3
14) chain C
residue 270
type
sequence K
description BINDING SITE FOR RESIDUE GDP C 357
source : AC3
15) chain C
residue 272
type
sequence D
description BINDING SITE FOR RESIDUE GDP C 357
source : AC3
16) chain C
residue 273
type
sequence L
description BINDING SITE FOR RESIDUE GDP C 357
source : AC3
17) chain C
residue 325
type
sequence C
description BINDING SITE FOR RESIDUE GDP C 357
source : AC3
18) chain C
residue 326
type
sequence A
description BINDING SITE FOR RESIDUE GDP C 357
source : AC3
19) chain C
residue 327
type
sequence T
description BINDING SITE FOR RESIDUE GDP C 357
source : AC3
20) chain D
residue 42
type
sequence G
description BINDING SITE FOR RESIDUE GDP D 358
source : AC4
21) chain D
residue 43
type
sequence E
description BINDING SITE FOR RESIDUE GDP D 358
source : AC4
22) chain D
residue 44
type
sequence S
description BINDING SITE FOR RESIDUE GDP D 358
source : AC4
23) chain D
residue 45
type
sequence G
description BINDING SITE FOR RESIDUE GDP D 358
source : AC4
24) chain D
residue 46
type
sequence K
description BINDING SITE FOR RESIDUE GDP D 358
source : AC4
25) chain D
residue 47
type
sequence S
description BINDING SITE FOR RESIDUE GDP D 358
source : AC4
26) chain D
residue 48
type
sequence T
description BINDING SITE FOR RESIDUE GDP D 358
source : AC4
27) chain D
residue 150
type
sequence D
description BINDING SITE FOR RESIDUE GDP D 358
source : AC4
28) chain D
residue 175
type
sequence L
description BINDING SITE FOR RESIDUE GDP D 358
source : AC4
29) chain D
residue 176
type
sequence R
description BINDING SITE FOR RESIDUE GDP D 358
source : AC4
30) chain D
residue 177
type
sequence T
description BINDING SITE FOR RESIDUE GDP D 358
source : AC4
31) chain D
residue 178
type
sequence R
description BINDING SITE FOR RESIDUE GDP D 358
source : AC4
32) chain D
residue 269
type
sequence N
description BINDING SITE FOR RESIDUE GDP D 358
source : AC4
33) chain D
residue 270
type
sequence K
description BINDING SITE FOR RESIDUE GDP D 358
source : AC4
34) chain D
residue 272
type
sequence D
description BINDING SITE FOR RESIDUE GDP D 358
source : AC4
35) chain D
residue 273
type
sequence L
description BINDING SITE FOR RESIDUE GDP D 358
source : AC4
36) chain D
residue 325
type
sequence C
description BINDING SITE FOR RESIDUE GDP D 358
source : AC4
37) chain D
residue 326
type
sequence A
description BINDING SITE FOR RESIDUE GDP D 358
source : AC4
38) chain D
residue 327
type
sequence T
description BINDING SITE FOR RESIDUE GDP D 358
source : AC4
39) chain C
residue 152
type BINDING
sequence A
description BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI3
40) chain D
residue 152
type BINDING
sequence A
description BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI3
41) chain C
residue 176
type BINDING
sequence R
description BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI4
42) chain D
residue 176
type BINDING
sequence R
description BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI4
43) chain C
residue 205
type MOD_RES
sequence R
description Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704
source Swiss-Prot : SWS_FT_FI8
44) chain D
residue 205
type MOD_RES
sequence R
description Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704
source Swiss-Prot : SWS_FT_FI8
45) chain C
residue 44
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI1
46) chain C
residue 270
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI1
47) chain D
residue 44
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI1
48) chain D
residue 270
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI1
49) chain C
residue 48
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0
source Swiss-Prot : SWS_FT_FI2
50) chain C
residue 182
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0
source Swiss-Prot : SWS_FT_FI2
51) chain D
residue 48
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0
source Swiss-Prot : SWS_FT_FI2
52) chain D
residue 182
type BINDING
sequence T
description BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0
source Swiss-Prot : SWS_FT_FI2
53) chain C
residue 179
type MOD_RES
sequence V
description ADP-ribosylarginine; by cholera toxin => ECO:0000250
source Swiss-Prot : SWS_FT_FI7
54) chain D
residue 179
type MOD_RES
sequence V
description ADP-ribosylarginine; by cholera toxin => ECO:0000250
source Swiss-Prot : SWS_FT_FI7
55) chain C
residue 201
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:21115486
source Swiss-Prot : SWS_FT_FI5
56) chain D
residue 201
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:21115486
source Swiss-Prot : SWS_FT_FI5
57) chain C
residue 327
type BINDING
sequence T
description BINDING => ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI6
58) chain D
residue 327
type BINDING
sequence T
description BINDING => ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
source Swiss-Prot : SWS_FT_FI6

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