eF-site ID 1xxv-ABCDEF PDB Code 1xxv Chain A, B, C, D, E, F click to enlarge Title Yersinia YopH (residues 163-468) binds phosphonodifluoromethyl-Phe containing hexapeptide at two sites Classification HYDROLASE Compound Protein-tyrosine phosphatase yopH Source Yersinia enterocolitica (1XXV) Sequence A:  SPYGPEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKL NRFRDIQCRRQTAVRADLNANYIQVGNTRTIACQYPLQSQ LESHFRMLAENRTPVLAVLASSSEIANQRFGMPDYFRQSG TYGSITVESKMTQQVGLGDGIMADMYTLTIREAGQKTISV PVVHVGNWPDQTAVSSEVTKALASLVDQTAETKRNMYESK GSSAVADDSKLRPVIHCRAGVGRTAQLIGAMCMNDSRNSQ LSVEDMVSQMRVQRNGIMVQKDEQLDVLIKLAEGQGRPLL NS B:  SPYGPEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKL NRFRDIQCRRQTAVRADLNANYIQVGNTRTIACQYPLQSQ LESHFRMLAENRTPVLAVLASSSEIANQRFGMPDYFRQSG TYGSITVESKMTQQVGLGDGIMADMYTLTIREAGQKTISV PVVHVGNWPDQTAVSSEVTKALASLVDQTAETKRNMYESK GSSAVADDSKLRPVIHCRAGVGRTAQLIGAMCMNDSRNSQ LSVEDMVSQMRVQRNGIMVQKDEQLDVLIKLAEGQGRPLL NS C:  DEXLX D:  DADEXLX E:  DEXLX F:  DADEXLX Description Functional site 1) chain A residue 229 type sequence F description BINDING SITE FOR CHAIN C OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC1 2) chain A residue 230 type sequence R description BINDING SITE FOR CHAIN C OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC1 3) chain A residue 231 type sequence D description BINDING SITE FOR CHAIN C OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC1 4) chain A residue 232 type sequence I description BINDING SITE FOR CHAIN C OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC1 5) chain A residue 356 type sequence D description BINDING SITE FOR CHAIN C OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC1 6) chain A residue 357 type sequence Q description BINDING SITE FOR CHAIN C OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC1 7) chain A residue 403 type sequence C description BINDING SITE FOR CHAIN C OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC1 8) chain A residue 404 type sequence R description BINDING SITE FOR CHAIN C OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC1 9) chain A residue 405 type sequence A description BINDING SITE FOR CHAIN C OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC1 10) chain A residue 406 type sequence G description BINDING SITE FOR CHAIN C OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC1 11) chain A residue 407 type sequence V description BINDING SITE FOR CHAIN C OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC1 12) chain A residue 408 type sequence G description BINDING SITE FOR CHAIN C OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC1 13) chain A residue 409 type sequence R description BINDING SITE FOR CHAIN C OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC1 14) chain A residue 446 type sequence Q description BINDING SITE FOR CHAIN C OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC1 15) chain C residue 107 type sequence X description BINDING SITE FOR CHAIN C OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC1 16) chain A residue 278 type sequence R description BINDING SITE FOR CHAIN D OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC2 17) chain A residue 295 type sequence R description BINDING SITE FOR CHAIN D OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC2 18) chain A residue 342 type sequence K description BINDING SITE FOR CHAIN D OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC2 19) chain A residue 343 type sequence T description BINDING SITE FOR CHAIN D OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC2 20) chain A residue 382 type sequence M description BINDING SITE FOR CHAIN D OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC2 21) chain A residue 386 type sequence K description BINDING SITE FOR CHAIN D OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC2 22) chain A residue 388 type sequence S description BINDING SITE FOR CHAIN D OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC2 23) chain A residue 389 type sequence S description BINDING SITE FOR CHAIN D OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC2 24) chain B residue 468 type sequence S description BINDING SITE FOR CHAIN D OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC2 25) chain D residue 7 type sequence X description BINDING SITE FOR CHAIN D OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC2 26) chain B residue 229 type sequence F description BINDING SITE FOR CHAIN E OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC3 27) chain B residue 230 type sequence R description BINDING SITE FOR CHAIN E OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC3 28) chain B residue 231 type sequence D description BINDING SITE FOR CHAIN E OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC3 29) chain B residue 232 type sequence I description BINDING SITE FOR CHAIN E OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC3 30) chain B residue 356 type sequence D description BINDING SITE FOR CHAIN E OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC3 31) chain B residue 357 type sequence Q description BINDING SITE FOR CHAIN E OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC3 32) chain B residue 403 type sequence C description BINDING SITE FOR CHAIN E OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC3 33) chain B residue 404 type sequence R description BINDING SITE FOR CHAIN E OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC3 34) chain B residue 405 type sequence A description BINDING SITE FOR CHAIN E OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC3 35) chain B residue 406 type sequence G description BINDING SITE FOR CHAIN E OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC3 36) chain B residue 407 type sequence V description BINDING SITE FOR CHAIN E OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC3 37) chain B residue 408 type sequence G description BINDING SITE FOR CHAIN E OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC3 38) chain B residue 409 type sequence R description BINDING SITE FOR CHAIN E OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC3 39) chain B residue 446 type sequence Q description BINDING SITE FOR CHAIN E OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC3 40) chain E residue 107 type sequence X description BINDING SITE FOR CHAIN E OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC3 41) chain A residue 468 type sequence S description BINDING SITE FOR CHAIN F OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC4 42) chain B residue 278 type sequence R description BINDING SITE FOR CHAIN F OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC4 43) chain B residue 295 type sequence R description BINDING SITE FOR CHAIN F OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC4 44) chain B residue 342 type sequence K description BINDING SITE FOR CHAIN F OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC4 45) chain B residue 343 type sequence T description BINDING SITE FOR CHAIN F OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC4 46) chain B residue 344 type sequence I description BINDING SITE FOR CHAIN F OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC4 47) chain B residue 345 type sequence S description BINDING SITE FOR CHAIN F OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC4 48) chain B residue 386 type sequence K description BINDING SITE FOR CHAIN F OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC4 49) chain B residue 388 type sequence S description BINDING SITE FOR CHAIN F OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC4 50) chain B residue 389 type sequence S description BINDING SITE FOR CHAIN F OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC4 51) chain F residue 7 type sequence X description BINDING SITE FOR CHAIN F OF EPIDERMAL GROWTH FACTOR RECEPTOR DERIVED PEPTIDE source : AC4 52) chain A residue 290 type catalytic sequence E description 47 source MCSA : MCSA1 53) chain A residue 354 type catalytic sequence W description 47 source MCSA : MCSA1 54) chain A residue 356 type catalytic sequence D description 47 source MCSA : MCSA1 55) chain A residue 402 type catalytic sequence H description 47 source MCSA : MCSA1 56) chain A residue 403 type catalytic sequence C description 47 source MCSA : MCSA1 57) chain A residue 409 type catalytic sequence R description 47 source MCSA : MCSA1 58) chain A residue 410 type catalytic sequence T description 47 source MCSA : MCSA1 59) chain B residue 290 type catalytic sequence E description 47 source MCSA : MCSA2 60) chain B residue 354 type catalytic sequence W description 47 source MCSA : MCSA2 61) chain B residue 356 type catalytic sequence D description 47 source MCSA : MCSA2 62) chain B residue 402 type catalytic sequence H description 47 source MCSA : MCSA2 63) chain B residue 403 type catalytic sequence C description 47 source MCSA : MCSA2 64) chain B residue 409 type catalytic sequence R description 47 source MCSA : MCSA2 65) chain B residue 410 type catalytic sequence T description 47 source MCSA : MCSA2 66) chain A residue 403 type ACT_SITE sequence C description Phosphocysteine intermediate source Swiss-Prot : SWS_FT_FI1 67) chain B residue 403 type ACT_SITE sequence C description Phosphocysteine intermediate source Swiss-Prot : SWS_FT_FI1 68) chain A residue 401-411 type prosite sequence IHCRAGVGRTA description TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. IHCraGvgRTA source prosite : PS00383

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