eF-site ID 1xvp-C PDB Code 1xvp Chain C click to enlarge Title crystal structure of CAR/RXR heterodimer bound with SRC1 peptide, fatty acid and CITCO Classification DNA BINDING PROTEIN Compound Retinoic acid receptor RXR-alpha Source Homo sapiens (Human) (NP_003734) Sequence C:  NEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVT NICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWN ELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIF DRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNP AEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALR SIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT Description Functional site 1) chain C residue 268 type sequence I description BINDING SITE FOR RESIDUE F15 C 1001 source : AC1 2) chain C residue 272 type sequence A description BINDING SITE FOR RESIDUE F15 C 1001 source : AC1 3) chain C residue 275 type sequence Q description BINDING SITE FOR RESIDUE F15 C 1001 source : AC1 4) chain C residue 313 type sequence F description BINDING SITE FOR RESIDUE F15 C 1001 source : AC1 5) chain C residue 316 type sequence R description BINDING SITE FOR RESIDUE F15 C 1001 source : AC1 6) chain C residue 326 type sequence L description BINDING SITE FOR RESIDUE F15 C 1001 source : AC1 7) chain C residue 327 type sequence A description BINDING SITE FOR RESIDUE F15 C 1001 source : AC1 8) chain C residue 345 type sequence I description BINDING SITE FOR RESIDUE F15 C 1001 source : AC1 9) chain C residue 432 type sequence C description BINDING SITE FOR RESIDUE F15 C 1001 source : AC1 10) chain C residue 316 type BINDING sequence R description BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6 source Swiss-Prot : SWS_FT_FI1 11) chain C residue 327 type BINDING sequence A description BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6 source Swiss-Prot : SWS_FT_FI1 12) chain C residue 259 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI2 13) chain C residue 260 type MOD_RES sequence S description Phosphoserine; by MAPK8 and MAPK9 => ECO:0000250|UniProtKB:P28700 source Swiss-Prot : SWS_FT_FI3

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