eF-site/Summary 1xv9-C

eF-site ID	1xv9-C
PDB Code	1xv9
Chain	C

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Title	crystal structure of CAR/RXR heterodimer bound with SRC1 peptide, fatty acid, and 5b-pregnane-3,20-dione.
Classification	DNA BINDING PROTEIN
Compound	Retinoic acid receptor RXR-alpha
Source	null (NP_003734)

Sequence	C:	NEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVT NICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWN ELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIF DRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNP AEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALR SIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAP

Description

Functional site


1)	chain	C
	residue	272
	type
	sequence	A
	description	BINDING SITE FOR RESIDUE F15 C 1002
	source	: AC2

2)	chain	C
	residue	275
	type
	sequence	Q
	description	BINDING SITE FOR RESIDUE F15 C 1002
	source	: AC2

3)	chain	C
	residue	309
	type
	sequence	L
	description	BINDING SITE FOR RESIDUE F15 C 1002
	source	: AC2

4)	chain	C
	residue	313
	type
	sequence	F
	description	BINDING SITE FOR RESIDUE F15 C 1002
	source	: AC2

5)	chain	C
	residue	316
	type
	sequence	R
	description	BINDING SITE FOR RESIDUE F15 C 1002
	source	: AC2

6)	chain	C
	residue	327
	type
	sequence	A
	description	BINDING SITE FOR RESIDUE F15 C 1002
	source	: AC2

7)	chain	C
	residue	345
	type
	sequence	I
	description	BINDING SITE FOR RESIDUE F15 C 1002
	source	: AC2

8)	chain	C
	residue	346
	type
	sequence	F
	description	BINDING SITE FOR RESIDUE F15 C 1002
	source	: AC2

9)	chain	C
	residue	432
	type
	sequence	C
	description	BINDING SITE FOR RESIDUE F15 C 1002
	source	: AC2

10)	chain	C
	residue	260
	type	MOD_RES
	sequence	S
	description	Phosphoserine; by MAPK8 and MAPK9 => ECO:0000250\|UniProtKB:P28700
	source	Swiss-Prot : SWS_FT_FI3

11)	chain	C
	residue	316
	type	BINDING
	sequence	R
	description	BINDING => ECO:0000269\|PubMed:16107141, ECO:0000269\|PubMed:18800767, ECO:0000269\|PubMed:19167885, ECO:0007744\|PDB:2ACL, ECO:0007744\|PDB:3FAL, ECO:0007744\|PDB:3FC6
	source	Swiss-Prot : SWS_FT_FI1

12)	chain	C
	residue	327
	type	BINDING
	sequence	A
	description	BINDING => ECO:0000269\|PubMed:16107141, ECO:0000269\|PubMed:18800767, ECO:0000269\|PubMed:19167885, ECO:0007744\|PDB:2ACL, ECO:0007744\|PDB:3FAL, ECO:0007744\|PDB:3FC6
	source	Swiss-Prot : SWS_FT_FI1

13)	chain	C
	residue	259
	type	MOD_RES
	sequence	S
	description	Phosphoserine => ECO:0007744\|PubMed:24275569
	source	Swiss-Prot : SWS_FT_FI2