eF-site ID 1xv9-ABCDEFGH PDB Code 1xv9 Chain A, B, C, D, E, F, G, H click to enlarge Title crystal structure of CAR/RXR heterodimer bound with SRC1 peptide, fatty acid, and 5b-pregnane-3,20-dione. Classification DNA BINDING PROTEIN Compound Retinoic acid receptor RXR-alpha Source Homo sapiens (Human) (NP_003734) Sequence A:  NEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVT NICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWN ELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIF DRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNP AEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALR SIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAP B:  PVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLF IHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLPVF RSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPL RYTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLL AAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRR PRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPL LQEICS C:  NEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVT NICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWN ELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIF DRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNP AEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALR SIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAP D:  PVQLSKEQEELIRTLLGAHTRHMGTMFEQFVQFRPPAHLF IHHQPLPTLAPVLPLVTHFADINTFMVLQVIKFTKDLPVF RSLPIEDQISLLKGAAVEICHIVLNTTFCLQTQNFLCGPL RYTIEDGARVGFQVEFLELLFHFHGTLRKLQLQEPEYVLL AAMALFSPDRPGVTQRDEIDQLQEEMALTLQSYIKGQQRR PRDRFLYAKLLGLLAELRSINEAYGYQIQHIQGLSAMMPL LQEICS E:  HKILHRLLQE F:  RHKILHRLLQEG G:  ERHKILHRLLQE H:  ERHKILHRLLQE Description Functional site 1) chain B residue 160 type sequence H description BINDING SITE FOR RESIDUE CI2 D 1001 source : AC1 2) chain B residue 161 type sequence F description BINDING SITE FOR RESIDUE CI2 D 1001 source : AC1 3) chain B residue 164 type sequence I description BINDING SITE FOR RESIDUE CI2 D 1001 source : AC1 4) chain B residue 165 type sequence N description BINDING SITE FOR RESIDUE CI2 D 1001 source : AC1 5) chain B residue 203 type sequence H description BINDING SITE FOR RESIDUE CI2 D 1001 source : AC1 6) chain B residue 224 type sequence Y description BINDING SITE FOR RESIDUE CI2 D 1001 source : AC1 7) chain B residue 238 type sequence F description BINDING SITE FOR RESIDUE CI2 D 1001 source : AC1 8) chain B residue 242 type sequence L description BINDING SITE FOR RESIDUE CI2 D 1001 source : AC1 9) chain B residue 326 type sequence Y description BINDING SITE FOR RESIDUE CI2 D 1001 source : AC1 10) chain D residue 161 type sequence F description BINDING SITE FOR RESIDUE CI2 D 1001 source : AC1 11) chain D residue 164 type sequence I description BINDING SITE FOR RESIDUE CI2 D 1001 source : AC1 12) chain D residue 165 type sequence N description BINDING SITE FOR RESIDUE CI2 D 1001 source : AC1 13) chain D residue 168 type sequence M description BINDING SITE FOR RESIDUE CI2 D 1001 source : AC1 14) chain D residue 203 type sequence H description BINDING SITE FOR RESIDUE CI2 D 1001 source : AC1 15) chain D residue 224 type sequence Y description BINDING SITE FOR RESIDUE CI2 D 1001 source : AC1 16) chain D residue 242 type sequence L description BINDING SITE FOR RESIDUE CI2 D 1001 source : AC1 17) chain D residue 326 type sequence Y description BINDING SITE FOR RESIDUE CI2 D 1001 source : AC1 18) chain C residue 272 type sequence A description BINDING SITE FOR RESIDUE F15 C 1002 source : AC2 19) chain C residue 275 type sequence Q description BINDING SITE FOR RESIDUE F15 C 1002 source : AC2 20) chain C residue 309 type sequence L description BINDING SITE FOR RESIDUE F15 C 1002 source : AC2 21) chain C residue 313 type sequence F description BINDING SITE FOR RESIDUE F15 C 1002 source : AC2 22) chain C residue 316 type sequence R description BINDING SITE FOR RESIDUE F15 C 1002 source : AC2 23) chain C residue 327 type sequence A description BINDING SITE FOR RESIDUE F15 C 1002 source : AC2 24) chain C residue 345 type sequence I description BINDING SITE FOR RESIDUE F15 C 1002 source : AC2 25) chain C residue 346 type sequence F description BINDING SITE FOR RESIDUE F15 C 1002 source : AC2 26) chain C residue 432 type sequence C description BINDING SITE FOR RESIDUE F15 C 1002 source : AC2 27) chain A residue 268 type sequence I description BINDING SITE FOR RESIDUE F15 A 1003 source : AC3 28) chain A residue 272 type sequence A description BINDING SITE FOR RESIDUE F15 A 1003 source : AC3 29) chain A residue 275 type sequence Q description BINDING SITE FOR RESIDUE F15 A 1003 source : AC3 30) chain A residue 313 type sequence F description BINDING SITE FOR RESIDUE F15 A 1003 source : AC3 31) chain A residue 316 type sequence R description BINDING SITE FOR RESIDUE F15 A 1003 source : AC3 32) chain A residue 327 type sequence A description BINDING SITE FOR RESIDUE F15 A 1003 source : AC3 33) chain A residue 345 type sequence I description BINDING SITE FOR RESIDUE F15 A 1003 source : AC3 34) chain A residue 316 type BINDING sequence R description BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6 source Swiss-Prot : SWS_FT_FI1 35) chain A residue 327 type BINDING sequence A description BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6 source Swiss-Prot : SWS_FT_FI1 36) chain C residue 316 type BINDING sequence R description BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6 source Swiss-Prot : SWS_FT_FI1 37) chain C residue 327 type BINDING sequence A description BINDING => ECO:0000269|PubMed:16107141, ECO:0000269|PubMed:18800767, ECO:0000269|PubMed:19167885, ECO:0007744|PDB:2ACL, ECO:0007744|PDB:3FAL, ECO:0007744|PDB:3FC6 source Swiss-Prot : SWS_FT_FI1 38) chain A residue 259 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI2 39) chain C residue 259 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI2 40) chain A residue 260 type MOD_RES sequence S description Phosphoserine; by MAPK8 and MAPK9 => ECO:0000250|UniProtKB:P28700 source Swiss-Prot : SWS_FT_FI3 41) chain C residue 260 type MOD_RES sequence S description Phosphoserine; by MAPK8 and MAPK9 => ECO:0000250|UniProtKB:P28700 source Swiss-Prot : SWS_FT_FI3

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