eF-site ID 1xtc-ACDEFGH PDB Code 1xtc Chain A, C, D, E, F, G, H click to enlarge Title CHOLERA TOXIN Classification TOXIN Compound CHOLERA TOXIN Source ORGANISM_SCIENTIFIC: Vibrio cholerae; Sequence A:  NDDKLYRADSRPPDEIKQSGGLMPRGQSEYFDRGTQMNIN LYDHARGTQTGFVRHDDGYVSTSISLRSAHLVGQTILSGH STYYLYVLATAPNMFNVNDVLGAYSPHPDEQEVSALGGIP YSQIYGWYRVHFGVLDEQLHRNRGYRDRYYSNLDIAPAAD GYGLAGFPPEHRAWREEPWIHHAPPGCGNAPR C:  SNTCDEKTQSLGVKFLDEYQSKVKRQIFSGYQSDIDTHNR IKDEL D:  TPQNITDLCAEYHNTQIYTLNDKIFSYTESLAGKREMAII TFKNGAIFQVEVPSSQHIDSQKKAIERMKDTLRIAYLTEA KVEKLCTWNNKTPHAIAAISMAN E:  TPQNITDLCAEYHNTQIYTLNDKIFSYTESLAGKREMAII TFKNGAIFQVEVPSSQHIDSQKKAIERMKDTLRIAYLTEA KVEKLCTWNNKTPHAIAAISMAN F:  TPQNITDLCAEYHNTQIYTLNDKIFSYTESLAGKREMAII TFKNGAIFQVEVPSSQHIDSQKKAIERMKDTLRIAYLTEA KVEKLCTWNNKTPHAIAAISMAN G:  TPQNITDLCAEYHNTQIYTLNDKIFSYTESLAGKREMAII TFKNGAIFQVEVPSSQHIDSQKKAIERMKDTLRIAYLTEA KVEKLCTWNNKTPHAIAAISMAN H:  TPQNITDLCAEYHNTQIYTLNDKIFSYTESLAGKREMAII TFKNGAIFQVEVPSSQHIDSQKKAIERMKDTLRIAYLTEA KVEKLCTWNNKTPHAIAAISMAN Description (1)  CHOLERA TOXIN Functional site 1) chain A residue 7 type sequence R description CATALYTIC SITE source : CAT 2) chain A residue 61 type sequence S description CATALYTIC SITE source : CAT 3) chain A residue 112 type sequence E description CATALYTIC SITE source : CAT 4) chain D residue 46 type sequence A description GANGLIOSIDE BINDING SITE IN CHAIN D source : GAD 5) chain D residue 51 type sequence E description GANGLIOSIDE BINDING SITE IN CHAIN D source : GAD 6) chain D residue 56 type sequence Q description GANGLIOSIDE BINDING SITE IN CHAIN D source : GAD 7) chain D residue 61 type sequence Q description GANGLIOSIDE BINDING SITE IN CHAIN D source : GAD 8) chain D residue 88 type sequence W description GANGLIOSIDE BINDING SITE IN CHAIN D source : GAD 9) chain D residue 90 type sequence N description GANGLIOSIDE BINDING SITE IN CHAIN D source : GAD 10) chain D residue 91 type sequence K description GANGLIOSIDE BINDING SITE IN CHAIN D source : GAD 11) chain E residue 46 type sequence A description GANGLIOSIDE BINDING SITE IN CHAIN E source : GAE 12) chain E residue 51 type sequence E description GANGLIOSIDE BINDING SITE IN CHAIN E source : GAE 13) chain E residue 56 type sequence Q description GANGLIOSIDE BINDING SITE IN CHAIN E source : GAE 14) chain E residue 61 type sequence Q description GANGLIOSIDE BINDING SITE IN CHAIN E source : GAE 15) chain E residue 88 type sequence W description GANGLIOSIDE BINDING SITE IN CHAIN E source : GAE 16) chain E residue 90 type sequence N description GANGLIOSIDE BINDING SITE IN CHAIN E source : GAE 17) chain E residue 91 type sequence K description GANGLIOSIDE BINDING SITE IN CHAIN E source : GAE 18) chain F residue 46 type sequence A description GANGLIOSIDE BINDING SITE IN CHAIN F source : GAF 19) chain F residue 51 type sequence E description GANGLIOSIDE BINDING SITE IN CHAIN F source : GAF 20) chain F residue 56 type sequence Q description GANGLIOSIDE BINDING SITE IN CHAIN F source : GAF 21) chain F residue 61 type sequence Q description GANGLIOSIDE BINDING SITE IN CHAIN F source : GAF 22) chain F residue 88 type sequence W description GANGLIOSIDE BINDING SITE IN CHAIN F source : GAF 23) chain F residue 90 type sequence N description GANGLIOSIDE BINDING SITE IN CHAIN F source : GAF 24) chain F residue 91 type sequence K description GANGLIOSIDE BINDING SITE IN CHAIN F source : GAF 25) chain G residue 46 type sequence A description GANGLIOSIDE BINDING SITE IN CHAIN G source : GAG 26) chain G residue 51 type sequence E description GANGLIOSIDE BINDING SITE IN CHAIN G source : GAG 27) chain G residue 56 type sequence Q description GANGLIOSIDE BINDING SITE IN CHAIN G source : GAG 28) chain G residue 61 type sequence Q description GANGLIOSIDE BINDING SITE IN CHAIN G source : GAG 29) chain G residue 88 type sequence W description GANGLIOSIDE BINDING SITE IN CHAIN G source : GAG 30) chain G residue 90 type sequence N description GANGLIOSIDE BINDING SITE IN CHAIN G source : GAG 31) chain G residue 91 type sequence K description GANGLIOSIDE BINDING SITE IN CHAIN G source : GAG 32) chain H residue 46 type sequence A description GANGLIOSIDE BINDING SITE IN CHAIN H source : GAH 33) chain H residue 51 type sequence E description GANGLIOSIDE BINDING SITE IN CHAIN H source : GAH 34) chain H residue 56 type sequence Q description GANGLIOSIDE BINDING SITE IN CHAIN H source : GAH 35) chain H residue 61 type sequence Q description GANGLIOSIDE BINDING SITE IN CHAIN H source : GAH 36) chain H residue 88 type sequence W description GANGLIOSIDE BINDING SITE IN CHAIN H source : GAH 37) chain H residue 90 type sequence N description GANGLIOSIDE BINDING SITE IN CHAIN H source : GAH 38) chain H residue 91 type sequence K description GANGLIOSIDE BINDING SITE IN CHAIN H source : GAH 39) chain C residue 237-240 type prosite sequence KDEL description ER_TARGET Endoplasmic reticulum targeting sequence. KDEL source prosite : PS00014 40) chain A residue 112 type ACT_SITE sequence E description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 41) chain A residue 23 type BINDING sequence M description BINDING => ECO:0000269|PubMed:16099990 source Swiss-Prot : SWS_FT_FI2 42) chain A residue 7 type BINDING sequence R description BINDING => ECO:0000269|PubMed:16099990 source Swiss-Prot : SWS_FT_FI2 43) chain A residue 7 type catalytic sequence R description 919 source MCSA : MCSA1 44) chain A residue 61 type catalytic sequence S description 919 source MCSA : MCSA1 45) chain A residue 110 type catalytic sequence E description 919 source MCSA : MCSA1 46) chain A residue 112 type catalytic sequence E description 919 source MCSA : MCSA1

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