eF-site ID 1xjn-AB PDB Code 1xjn Chain A, B click to enlarge Title Structural mechanism of allosteric substrate specificity in a ribonucleotide reductase: dATP-CDP complex Classification OXIDOREDUCTASE Compound ribonucleotide reductase, B12-dependent Source null (O33839_THEMA) Sequence A:  MKLSDLISRWIDVEPSKNAQIILRDRYFMKLDGNYLETKW EDVARRVARVVATAELLNPSYKKNEKLDRIKEWEDIFFRV LKARLFIPNSPTLFNAGLGVKHDLLWKPIDQMTLEDYEEI YRSRNHLHMLSACFVVPVGDSIEEIFEAVKEYALITKVGG GVGSNFSELRPKGSFVAGTGKASGPVSFMHVFNSAISVVK QGGALMGILNINHPDIEEFIDAKKVLNFFNLSVGFPMDKK EILKLYEEDGELELSHPRSTIRKKVKIRELFRKIATNAWK SGDPGLAFLGEMNKYYPLYPHRKINSTNPCGEIGLSDYEA CNLGSIDVAKFYNNGFVDLEALQELVQIAVRFLDNVIDVN VFPIDKITKAVKESRRLGLGIMGFADLLYKLEIPYNSQEA RDFAANLMAFIALHAHRTSYELGKEKGNFPLLEISRYRTE DNFVPFAMGMSNYDDEIREVMKMTKEFRRNVALLTIAPTG SISNIADTSSGLEPNFLLAYTRFVTKEDEPLLYVNQVLRE KLNPEILKRIEKELIEKGSLKDIPDVPEKIKKVFVVALDI DPMDHLLMQDAFQRYVDNNISKTINMPQSATVDDVLNVYL EALRTNVRGITVYRDGSL B:  MKLSDLISRWIDVEPSKNAQIILRDRYFMKDLDGNYLETK WEDVARRVARVVATAELLNPSYKKNEKLDRIKEWEDIFFR VLKARLFIPNSPTLFNAGLGVKHDLLWKPIDQMTLEDYEE IYRSRNHLHMLSACFVVPVGDSIEEIFEAVKEYALITKVG GGVGSNFSELRPKGSFVAGTHGKASGPVSFMHVFNSAISV VKQRRGALMGILNINHPDIEEFIDAKKVLNFFNLSVGFPM DKKEILKLYEEDGELELSHPRSTIRKKVKIRELFRKIATN AWKSGDPGLAFLGEMNKYYPLYPHRKINSTNPCGEIGLSD YEACNLGSIDVAKFYNNGFVDLEALQELVQIAVRFLDNVI DVNVFPIDKITKAVKESRRLGLGIMGFADLLYKLEIPYNS QEARDFAANLMAFIALHAHRTSYELGKEKGNFPLLEISRY RTEDNFVPFAMGMSNYDDEIREVMKMTKEFRRNVALLTIA PTGSISNIADTSSGLEPNFLLAYTRPLLYVNQVLREKLNP EIEKELIEKGSLKDIPDVPEKIKKVFVVALDIDPMDHLLM QDAFQRYVDNNISKTINMPQSATVDDVLNVYLEALRTNVR GITVYRDGSL Description Functional site 1) chain B residue 91 type sequence S description BINDING SITE FOR RESIDUE CL B 1009 source : AC1 2) chain B residue 207 type sequence R description BINDING SITE FOR RESIDUE CL B 1009 source : AC1 3) chain B residue 90 type sequence N description BINDING SITE FOR RESIDUE CDP B 1001 source : AC2 4) chain B residue 91 type sequence S description BINDING SITE FOR RESIDUE CDP B 1001 source : AC2 5) chain B residue 133 type sequence A description BINDING SITE FOR RESIDUE CDP B 1001 source : AC2 6) chain B residue 162 type sequence G description BINDING SITE FOR RESIDUE CDP B 1001 source : AC2 7) chain B residue 203 type sequence Q description BINDING SITE FOR RESIDUE CDP B 1001 source : AC2 8) chain B residue 207 type sequence R description BINDING SITE FOR RESIDUE CDP B 1001 source : AC2 9) chain B residue 208 type sequence R description BINDING SITE FOR RESIDUE CDP B 1001 source : AC2 10) chain B residue 320 type sequence N description BINDING SITE FOR RESIDUE CDP B 1001 source : AC2 11) chain B residue 321 type sequence P description BINDING SITE FOR RESIDUE CDP B 1001 source : AC2 12) chain B residue 322 type sequence C description BINDING SITE FOR RESIDUE CDP B 1001 source : AC2 13) chain B residue 324 type sequence E description BINDING SITE FOR RESIDUE CDP B 1001 source : AC2 14) chain B residue 489 type sequence A description BINDING SITE FOR RESIDUE CDP B 1001 source : AC2 15) chain B residue 490 type sequence P description BINDING SITE FOR RESIDUE CDP B 1001 source : AC2 16) chain B residue 491 type sequence T description BINDING SITE FOR RESIDUE CDP B 1001 source : AC2 17) chain B residue 492 type sequence G description BINDING SITE FOR RESIDUE CDP B 1001 source : AC2 18) chain B residue 493 type sequence S description BINDING SITE FOR RESIDUE CDP B 1001 source : AC2 19) chain B residue 494 type sequence I description BINDING SITE FOR RESIDUE CDP B 1001 source : AC2 20) chain A residue 90 type sequence N description BINDING SITE FOR RESIDUE CDP A 1002 source : AC3 21) chain A residue 91 type sequence S description BINDING SITE FOR RESIDUE CDP A 1002 source : AC3 22) chain A residue 133 type sequence A description BINDING SITE FOR RESIDUE CDP A 1002 source : AC3 23) chain A residue 162 type sequence G description BINDING SITE FOR RESIDUE CDP A 1002 source : AC3 24) chain A residue 203 type sequence Q description BINDING SITE FOR RESIDUE CDP A 1002 source : AC3 25) chain A residue 210 type sequence A description BINDING SITE FOR RESIDUE CDP A 1002 source : AC3 26) chain A residue 320 type sequence N description BINDING SITE FOR RESIDUE CDP A 1002 source : AC3 27) chain A residue 321 type sequence P description BINDING SITE FOR RESIDUE CDP A 1002 source : AC3 28) chain A residue 322 type sequence C description BINDING SITE FOR RESIDUE CDP A 1002 source : AC3 29) chain A residue 324 type sequence E description BINDING SITE FOR RESIDUE CDP A 1002 source : AC3 30) chain A residue 489 type sequence A description BINDING SITE FOR RESIDUE CDP A 1002 source : AC3 31) chain A residue 490 type sequence P description BINDING SITE FOR RESIDUE CDP A 1002 source : AC3 32) chain A residue 491 type sequence T description BINDING SITE FOR RESIDUE CDP A 1002 source : AC3 33) chain A residue 492 type sequence G description BINDING SITE FOR RESIDUE CDP A 1002 source : AC3 34) chain A residue 493 type sequence S description BINDING SITE FOR RESIDUE CDP A 1002 source : AC3 35) chain A residue 494 type sequence I description BINDING SITE FOR RESIDUE CDP A 1002 source : AC3 36) chain A residue 141 type sequence D description BINDING SITE FOR RESIDUE DTP A 1005 source : AC6 37) chain A residue 142 type sequence S description BINDING SITE FOR RESIDUE DTP A 1005 source : AC6 38) chain A residue 143 type sequence I description BINDING SITE FOR RESIDUE DTP A 1005 source : AC6 39) chain A residue 171 type sequence R description BINDING SITE FOR RESIDUE DTP A 1005 source : AC6 40) chain A residue 177 type sequence V description BINDING SITE FOR RESIDUE DTP A 1005 source : AC6 41) chain A residue 178 type sequence A description BINDING SITE FOR RESIDUE DTP A 1005 source : AC6 42) chain A residue 185 type sequence S description BINDING SITE FOR RESIDUE DTP A 1005 source : AC6 43) chain B residue 158 type sequence K description BINDING SITE FOR RESIDUE DTP A 1005 source : AC6 44) chain B residue 200 type sequence V description BINDING SITE FOR RESIDUE DTP A 1005 source : AC6 45) chain B residue 201 type sequence V description BINDING SITE FOR RESIDUE DTP A 1005 source : AC6 46) chain B residue 202 type sequence K description BINDING SITE FOR RESIDUE DTP A 1005 source : AC6 47) chain A residue 127 type sequence H description BINDING SITE FOR RESIDUE DTP B 1006 source : AC7 48) chain A residue 158 type sequence K description BINDING SITE FOR RESIDUE DTP B 1006 source : AC7 49) chain A residue 200 type sequence V description BINDING SITE FOR RESIDUE DTP B 1006 source : AC7 50) chain A residue 202 type sequence K description BINDING SITE FOR RESIDUE DTP B 1006 source : AC7 51) chain B residue 141 type sequence D description BINDING SITE FOR RESIDUE DTP B 1006 source : AC7 52) chain B residue 142 type sequence S description BINDING SITE FOR RESIDUE DTP B 1006 source : AC7 53) chain B residue 143 type sequence I description BINDING SITE FOR RESIDUE DTP B 1006 source : AC7 54) chain B residue 171 type sequence R description BINDING SITE FOR RESIDUE DTP B 1006 source : AC7 55) chain B residue 177 type sequence V description BINDING SITE FOR RESIDUE DTP B 1006 source : AC7 56) chain B residue 183 type sequence K description BINDING SITE FOR RESIDUE DTP B 1006 source : AC7 57) chain B residue 184 type sequence A description BINDING SITE FOR RESIDUE DTP B 1006 source : AC7 58) chain B residue 185 type sequence S description BINDING SITE FOR RESIDUE DTP B 1006 source : AC7 59) chain B residue 190 type sequence F description BINDING SITE FOR RESIDUE DTP B 1006 source : AC7

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