eF-site ID 1xje-AB PDB Code 1xje Chain A, B click to enlarge Title Structural mechanism of allosteric substrate specificity in a ribonucleotide reductase: dTTP-GDP complex Classification OXIDOREDUCTASE Compound ribonucleotide reductase, B12-dependent Source null (O33839_THEMA) Sequence A:  MKLSDLISRWIDVEPSKNAQIILRDRYFMKDLDGNYLETK WEDVARRVARVVATAELLNPSYKKNEKLDRIKEWEDIFFR VLKARLFIPNSPTLFNAGLGVKHDLLWKPIDQMTLEDYEE IYRSRNHLHMLSACFVVPVGDSIEEIFEAVKEYALITKVG GGVGSNFSELRPKGSFVAGTHGKASGPVSFMHVFNSAISV VKQGSRRRGALMGILNINHPDIEEFIDAKKVLNFFNLSVG FPMDKKEILKLYEEDGELELSHPRSTIRKKVKIRELFRKI ATNAWKSGDPGLAFLGEMNKYYPLYPHRKINSTNPCGEIG LSDYEACNLGSIDVAKFYNNGFVDLEALQELVQIAVRFLD NVIDVNVFPIDKITKAVKESRRLGLGIMGFADLLYKLEIP YNSQEARDFAANLMAFIALHAHRTSYELGKEKGNFPLLEI SRYRTEDNFVPFAMGMSNYDDEIREVMKMTKEFRRNVALL TIAPTGSISNIADTSSGLEPNFLLAYTRFVTKEDGTKEPL LYVNQVLREKLNPEILKRIEKELIEKGSLKDIPDVPEKIK KVFVVALDIDPMDHLLMQDAFQRYVDNNISKTINMPQSAT VDDVLNVYLEALRTNVRGITVYRDGSL B:  MKLSDLISRWIDVEPSKNAQIILRDRYFMKDLDGNYLETK WEDVARRVARVVATAELLNPSYKKNEKLDRIKEWEDIFFR VLKARLFIPNSPTLFNAGLGVKHDLLWKPIDQMTLEDYEE IYRSRNHLHMLSACFVVPVGDSIEEIFEAVKEYALITKVG GGVGSNFSELRPKGSFVAGTHGKASGPVSFMHVFNSAISV VKQGSRRRGALMGILNINHPDIEEFIDAKKVLNFFNLSVG FPMDKKEILKLYEEDGELELSHPRSTIRKKVKIRELFRKI ATNAWKSGDPGLAFLGEMNKYYPLYPHRKINSTNPCGEIG LSDYEACNLGSIDVAKFYNNGFVDLEALQELVQIAVRFLD NVIDVNVFPIDKITKAVKESRRLGLGIMGFADLLYKLEIP YNSQEARDFAANLMAFIALHAHRTSYELGKEKGNFPLLEI SRYRTEDNFVPFAMGMSNYDDEIREVMKMTKEFRRNVALL TIAPTGSISNIADTSSGLEPNFLLAYTRFPLLYVNQVLRE KLNPEILKRIEKELIEKGSLKDIPDVPEKIKKVFVVALDI DPMDHLLMQDAFQRYVDNNISKTINMPQSATVDDVLNVYL EALRTNVRGITVYRDGSL Description Functional site 1) chain A residue 90 type sequence N description BINDING SITE FOR RESIDUE GDP A 1002 source : AC3 2) chain A residue 91 type sequence S description BINDING SITE FOR RESIDUE GDP A 1002 source : AC3 3) chain A residue 133 type sequence A description BINDING SITE FOR RESIDUE GDP A 1002 source : AC3 4) chain A residue 161 type sequence G description BINDING SITE FOR RESIDUE GDP A 1002 source : AC3 5) chain A residue 207 type sequence R description BINDING SITE FOR RESIDUE GDP A 1002 source : AC3 6) chain A residue 208 type sequence R description BINDING SITE FOR RESIDUE GDP A 1002 source : AC3 7) chain A residue 210 type sequence A description BINDING SITE FOR RESIDUE GDP A 1002 source : AC3 8) chain A residue 320 type sequence N description BINDING SITE FOR RESIDUE GDP A 1002 source : AC3 9) chain A residue 321 type sequence P description BINDING SITE FOR RESIDUE GDP A 1002 source : AC3 10) chain A residue 322 type sequence C description BINDING SITE FOR RESIDUE GDP A 1002 source : AC3 11) chain A residue 324 type sequence E description BINDING SITE FOR RESIDUE GDP A 1002 source : AC3 12) chain A residue 489 type sequence A description BINDING SITE FOR RESIDUE GDP A 1002 source : AC3 13) chain A residue 490 type sequence P description BINDING SITE FOR RESIDUE GDP A 1002 source : AC3 14) chain A residue 491 type sequence T description BINDING SITE FOR RESIDUE GDP A 1002 source : AC3 15) chain A residue 492 type sequence G description BINDING SITE FOR RESIDUE GDP A 1002 source : AC3 16) chain A residue 493 type sequence S description BINDING SITE FOR RESIDUE GDP A 1002 source : AC3 17) chain A residue 494 type sequence I description BINDING SITE FOR RESIDUE GDP A 1002 source : AC3 18) chain B residue 90 type sequence N description BINDING SITE FOR RESIDUE GDP B 1003 source : AC4 19) chain B residue 91 type sequence S description BINDING SITE FOR RESIDUE GDP B 1003 source : AC4 20) chain B residue 133 type sequence A description BINDING SITE FOR RESIDUE GDP B 1003 source : AC4 21) chain B residue 161 type sequence G description BINDING SITE FOR RESIDUE GDP B 1003 source : AC4 22) chain B residue 207 type sequence R description BINDING SITE FOR RESIDUE GDP B 1003 source : AC4 23) chain B residue 208 type sequence R description BINDING SITE FOR RESIDUE GDP B 1003 source : AC4 24) chain B residue 210 type sequence A description BINDING SITE FOR RESIDUE GDP B 1003 source : AC4 25) chain B residue 320 type sequence N description BINDING SITE FOR RESIDUE GDP B 1003 source : AC4 26) chain B residue 321 type sequence P description BINDING SITE FOR RESIDUE GDP B 1003 source : AC4 27) chain B residue 322 type sequence C description BINDING SITE FOR RESIDUE GDP B 1003 source : AC4 28) chain B residue 324 type sequence E description BINDING SITE FOR RESIDUE GDP B 1003 source : AC4 29) chain B residue 489 type sequence A description BINDING SITE FOR RESIDUE GDP B 1003 source : AC4 30) chain B residue 490 type sequence P description BINDING SITE FOR RESIDUE GDP B 1003 source : AC4 31) chain B residue 491 type sequence T description BINDING SITE FOR RESIDUE GDP B 1003 source : AC4 32) chain B residue 492 type sequence G description BINDING SITE FOR RESIDUE GDP B 1003 source : AC4 33) chain B residue 493 type sequence S description BINDING SITE FOR RESIDUE GDP B 1003 source : AC4 34) chain B residue 494 type sequence I description BINDING SITE FOR RESIDUE GDP B 1003 source : AC4 35) chain A residue 158 type sequence K description BINDING SITE FOR RESIDUE TTP B 1004 source : AC5 36) chain A residue 200 type sequence V description BINDING SITE FOR RESIDUE TTP B 1004 source : AC5 37) chain A residue 201 type sequence V description BINDING SITE FOR RESIDUE TTP B 1004 source : AC5 38) chain A residue 202 type sequence K description BINDING SITE FOR RESIDUE TTP B 1004 source : AC5 39) chain B residue 141 type sequence D description BINDING SITE FOR RESIDUE TTP B 1004 source : AC5 40) chain B residue 142 type sequence S description BINDING SITE FOR RESIDUE TTP B 1004 source : AC5 41) chain B residue 143 type sequence I description BINDING SITE FOR RESIDUE TTP B 1004 source : AC5 42) chain B residue 171 type sequence R description BINDING SITE FOR RESIDUE TTP B 1004 source : AC5 43) chain B residue 177 type sequence V description BINDING SITE FOR RESIDUE TTP B 1004 source : AC5 44) chain B residue 178 type sequence A description BINDING SITE FOR RESIDUE TTP B 1004 source : AC5 45) chain B residue 179 type sequence G description BINDING SITE FOR RESIDUE TTP B 1004 source : AC5 46) chain B residue 184 type sequence A description BINDING SITE FOR RESIDUE TTP B 1004 source : AC5 47) chain B residue 185 type sequence S description BINDING SITE FOR RESIDUE TTP B 1004 source : AC5 48) chain B residue 190 type sequence F description BINDING SITE FOR RESIDUE TTP B 1004 source : AC5 49) chain A residue 141 type sequence D description BINDING SITE FOR RESIDUE TTP A 1005 source : AC6 50) chain A residue 142 type sequence S description BINDING SITE FOR RESIDUE TTP A 1005 source : AC6 51) chain A residue 143 type sequence I description BINDING SITE FOR RESIDUE TTP A 1005 source : AC6 52) chain A residue 171 type sequence R description BINDING SITE FOR RESIDUE TTP A 1005 source : AC6 53) chain A residue 177 type sequence V description BINDING SITE FOR RESIDUE TTP A 1005 source : AC6 54) chain A residue 178 type sequence A description BINDING SITE FOR RESIDUE TTP A 1005 source : AC6 55) chain A residue 179 type sequence G description BINDING SITE FOR RESIDUE TTP A 1005 source : AC6 56) chain A residue 184 type sequence A description BINDING SITE FOR RESIDUE TTP A 1005 source : AC6 57) chain A residue 185 type sequence S description BINDING SITE FOR RESIDUE TTP A 1005 source : AC6 58) chain A residue 190 type sequence F description BINDING SITE FOR RESIDUE TTP A 1005 source : AC6 59) chain B residue 158 type sequence K description BINDING SITE FOR RESIDUE TTP A 1005 source : AC6 60) chain B residue 200 type sequence V description BINDING SITE FOR RESIDUE TTP A 1005 source : AC6 61) chain B residue 201 type sequence V description BINDING SITE FOR RESIDUE TTP A 1005 source : AC6 62) chain B residue 202 type sequence K description BINDING SITE FOR RESIDUE TTP A 1005 source : AC6 63) chain A residue 144 type sequence E description BINDING SITE FOR RESIDUE GOL B 1001 source : AC7 64) chain B residue 127 type sequence H description BINDING SITE FOR RESIDUE GOL B 1001 source : AC7 65) chain B residue 158 type sequence K description BINDING SITE FOR RESIDUE GOL B 1001 source : AC7

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