eF-site ID 1xd3-C PDB Code 1xd3 Chain C click to enlarge Title Crystal structure of UCHL3-UbVME complex Classification HYDROLASE Compound Ubiquitin Carboxyl-terminal esterase L3 Source Homo sapiens (Human) (UBIQ_HUMAN) Sequence C:  QRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMDPELLS MVPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSS VYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLKKFL EESVSMSPEERARYLENYDAIRVTHETSAHEGQTEAPSID EKVDLHFIALVHVDGHLYELDGRKPFPINHGETSDETLLE DAIEVCKKFMERDPDELRFNAIALSAA Description Functional site 1) chain C residue 163 type sequence D description BINDING SITE FOR RESIDUE MG C 2001 source : AC1 2) chain C residue 179 type sequence H description BINDING SITE FOR RESIDUE MG C 2003 source : AC3 3) chain C residue 78 type sequence Q description BINDING SITE FOR RESIDUE MG C 2005 source : AC5 4) chain C residue 79 type sequence D description BINDING SITE FOR RESIDUE MG C 2005 source : AC5 5) chain C residue 149 type sequence E description BINDING SITE FOR RESIDUE MG C 2007 source : AC7 6) chain C residue 79 type sequence D description BINDING SITE FOR RESIDUE MG C 2008 source : AC8 7) chain C residue 81 type sequence T description BINDING SITE FOR RESIDUE MG C 2008 source : AC8 8) chain C residue 181 type sequence Y description BINDING SITE FOR RESIDUE MG C 2008 source : AC8 9) chain C residue 89 type sequence Q description BINDING SITE FOR RESIDUE GVE D 2276 source : BC3 10) chain C residue 93 type sequence N description BINDING SITE FOR RESIDUE GVE D 2276 source : BC3 11) chain C residue 95 type sequence C description BINDING SITE FOR RESIDUE GVE D 2276 source : BC3 12) chain C residue 166 type sequence V description BINDING SITE FOR RESIDUE GVE D 2276 source : BC3 13) chain C residue 168 type sequence L description BINDING SITE FOR RESIDUE GVE D 2276 source : BC3 14) chain C residue 169 type sequence H description BINDING SITE FOR RESIDUE GVE D 2276 source : BC3 15) chain C residue 89 type catalytic sequence Q description 597 source MCSA : MCSA2 16) chain C residue 95 type catalytic sequence C description 597 source MCSA : MCSA2 17) chain C residue 169 type catalytic sequence H description 597 source MCSA : MCSA2 18) chain C residue 184 type catalytic sequence D description 597 source MCSA : MCSA2 19) chain C residue 95 type ACT_SITE sequence C description Nucleophile => ECO:0000269|PubMed:19154770, ECO:0000269|PubMed:20380862, ECO:0000269|PubMed:9790970 source Swiss-Prot : SWS_FT_FI1 20) chain C residue 169 type ACT_SITE sequence H description Proton donor => ECO:0000250|UniProtKB:P09936 source Swiss-Prot : SWS_FT_FI2 21) chain C residue 130 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI4 22) chain C residue 184 type SITE sequence D description Important for enzyme activity => ECO:0000250|UniProtKB:P09936 source Swiss-Prot : SWS_FT_FI3

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